Antiproliferative effects of 1α,25-dihydroxyvitamin D3 and vitamin D analogs on tumor-derived endothelial cells

Endocrinology

Volumn 143, Issue 7, 2002, Pages 2508-2514

  Bernardi, Ronald J ^a   Johnson, Candace S ^a   Modzelewski, Ruth A ^a   Trump, Donald L ^a,b,c  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,25 DIHYDROXY 16 ENE 23 YNE 26,27 HEXAFLUORO 19 NOR CHOLECALCIFEROL; 1,25 DIHYDROXY 16 ENE YNE CHOLECALCIFEROL; ANGIOPOIETIN 2; ANTINEOPLASTIC AGENT; CALCITRIOL; DEXAMETHASONE; ILX 237553; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN KINASE B; PROTEIN P27; RO 256760; SEOCALCITOL; UNCLASSIFIED DRUG; VITAMIN D DERIVATIVE; VITAMIN D RECEPTOR; ANGIOGENESIS INHIBITOR; ANGIOTENSIN II; ANTIINFLAMMATORY AGENT; CRYSTAL VIOLET; DRUG DERIVATIVE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; VITAMIN D;

ANGIOGENESIS; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; AORTA; ARTICLE; CANCER MODEL; CELL CYCLE; CELL GROWTH; CELL SURVIVAL; DOWN REGULATION; DRUG EFFECT; DRUG POTENCY; ENDOTHELIUM CELL; FIBROSARCOMA; GROWTH INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; ANIMAL; APOPTOSIS; BIOSYNTHESIS; CELL CULTURE; CELL DIVISION; CYTOLOGY; DRUG ANTAGONISM; DRUG POTENTIATION; METABOLISM; MOUSE; NEOPLASM; PATHOLOGY; VASCULAR ENDOTHELIUM; WESTERN BLOTTING;

ANGIOGENESIS INHIBITORS; ANGIOTENSIN II; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CALCITRIOL; CARCINOMA, SQUAMOUS CELL; CELL DIVISION; DEXAMETHASONE; DRUG SYNERGISM; ENDOTHELIUM, VASCULAR; GENTIAN VIOLET; INDICATORS AND REAGENTS; MICE; NEOPLASMS; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; VITAMIN D;

EID: 85047685002     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.143.7.8887     Document Type: Article

References (53)

1. Vitamin D: Role in the calcium economy
2. Vitamin D: Anticancer and differentiation
3. 3 analog in a squamous cell carcinoma model system
4. What is the evidence that tumors are angiogenesis dependent?
5. Calreticulin and calreticulin fragments are endothelial cell inhibitors that suppress tumor growth
6. Anti-angiogenic activity of selected receptor tyrosine kinase inhibitors, PD166285 and PD173074: Implications for combination treatment with photodynamic therapy
7. Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
8. 3. Studies in cultured bovine aortic endothelial cells and human dermal capillaries
9. 3 analogues
10. Vitamin D inhibits angiogenesis in transgenic murine retinoblastoma
11. 3 of colon carcinogenesis induced by azoxymethane in Wistar rats
12. 3 inhibits angiogenesis in vitro and in vivo
13. Isolation and identification of fresh tumor-derived endothelial cells from a murine RIF-1 fibrosarcoma
14. Interleukin 1α and γ-interferon induction of nitric oxide production from murine tumor-derived endothelial cells
15. A novel approach for the identification of unique tumor vasculature binding peptides using an E. coli peptide display library
16. Genes expressed in human tumor endothelium
17. A phase 1 trial of calcitriol (1,25-dihydroxycholecalciferol) in patients with advanced malignancy
18. 3 (calcitriol)
19. Phase II trial of oral 1,25-dihydroxyvitamin D (calcitriol) in hormone refractory prostate cancer
20. 3-mediated antitumor activity with dexamethasone
21. Modification of the effects of continuous low dose rate irradiation by concurrent chemotherapy infusion
22. A new mouse tumor model system (RIF-1) for comparison of end-point studies
23. Waf1/Cip1 in vitro and in vivo
24. History of the development of new vitamin D analogs: Studies on 22-oxacalcitriol (OCT) and 2β-(3-hydroxypropoxy)calcitriol (ED-71)
25. 3 with dexamethasone enhances cell cycle arrest and apoptosis: Role of nuclear receptor cross-talk and Erk/Akt signaling
26. 3-induced apoptosis of murine squamous cell carcinoma cells. Selective induction of caspase-dependent MEK cleavage and up-regulation of MEKK-1
27. Induction of apoptosis in breast cancer cells in response to vitamin D and antiestrogens
28. Vitamin D inhibition of prostate adenocarcinoma growth and metastasis in the Dunning rat prostate model system
29. 3
30. The microtubule-affecting drug paclitaxel has antiangiogenic activity
31. Vinca alkaloids: Antivascular effects in a murine tumour
32. Antiangiogenic potential of camptothecin and topotecan
33. Antiangiogenic chemotherapeutic agents
34. In vivo intracellular signaling as a marker of antiangiogenic activity
35. Vitamin D inhibits endothelial cell migration
36. Vitamin D analogs modulate the action of gonadal steroids in human vascular cells in vitro
37. Cytokine-stimulated human dermal microvascular endothelial cells produce interleukin 6: Inhibition by hydrocortisone, dexamethasone, and calcitriol
38. Cell surface tumor endothelial markers are conserved in mice and humans
39. Specialization of tumor vasculature
40. Angiogenesis in cancer and other diseases
41. Endothelial cells of tumor vessels: Abnormal but not absent
42. Effects of synthetic vitamin D analogues on breast cancer cell proliferation in vivo and in vitro
43. 3
44. Structure-function relationships in the vitamin D endocrine system
45. Mechanisms for the selective actions of vitamin D analogs
46. Pharmacologic interruption of the mitogen-activated extracellular-regulated kinase/mitogen-activated protein kinase signal transduction pathway: Potential role in promoting cytotoxic drug action
47. Overexpression of Akt/AKT can modulate chemotherapy-induced apoptosis
48. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
49. Expression of angiogenesis stimulators and inhibitors in human thyroid tumors and correlation with clinical pathological features
50. Expression of Tie1, Tie2, and angiopoietins 1, 2, and 4 in Kaposi's sarcoma and cutaneous angiosarcoma
51. New model of tumor angiogenesis: Dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF
52. The effects of angiopoietin-1 and -2 on tumor growth and angiogenesis in human colon cancer
53. Angiopoietin-2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway