Structures for the potential drug target purine nucleoside phosphorylase from Schistosoma mansoni causal agent of schistosomiasis

Journal of Molecular Biology

Volumn 353, Issue 3, 2005, Pages 584-599

  Pereira, Humberto D'Muniz ^a   Franco, Glória Regina ^b   Cleasby, Anne ^c   Garratt, Richard Charles ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^c ASTEX PHARMACEUTICALS   (United Kingdom)

Author keywords

Crystal structure; Non detergent sulfobetaine 195; PNP complexes; Purine nucleoside phosphorylase; Schistosoma mansoni

Indexed keywords

ACETIC ACID; BETAINE DERIVATIVE; HYPOXANTHINE; NUCLEOSIDE; PHOSPHATE; PURINE NUCLEOSIDE PHOSPHORYLASE; RIBOSE;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTALLIZATION; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME METABOLISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SYNTHESIS; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS;

MAMMALIA; SCHISTOSOMA MANSONI;

EID: 26444499643     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2005.08.045     Document Type: Article

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