Promoter analysis of tumor suppressor gene PTEN: Identification of minimum promoter region

Biochemical and Biophysical Research Communications

Volumn 292, Issue 2, 2002, Pages 422-426

  Sheng, Xiaoyang ^a   Koul, Dimpy ^a   Liu, Juinn Lin ^a   Liu, Ta Jen ^a   Yung, W K Alfred ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

p53 binding site; PTEN promoter

Indexed keywords

ADENINE; DNA FRAGMENT; GENOMIC DNA; GUANINE; LUCIFERASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PRIMER DNA; PROTEIN P53; THYMINE;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; DNA FLANKING REGION; DNA SEQUENCE; ENZYMATIC ASSAY; GENE DELETION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GENE ISOLATION; GENE LOCUS; GENETIC ANALYSIS; HUMAN; HUMAN CELL; MOLECULAR CLONING; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; START CODON; STOP CODON; TRANSLATION INITIATION; TUMOR SUPPRESSOR GENE;

EID: 0036291334     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2002.6662     Document Type: Article

References (24)

1. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
2. TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta
3. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
4. P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase
5. Somatic mutations of PTEN in glioblastoma multiforme
6. Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma
7. Genomic organization and mutation analysis of Hel-N1 in lung cancers with chromosome 9p21 deletions
8. Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas
9. Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies
10. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
11. Germline mutations in PTEN are present in Bannayan-Zonana syndrome
12. Her-2/neu overexpression induces NF-kappaB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IkappaB-alpha that can be inhibited by the tumor suppressor PTEN
13. Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: Differential involvement of focal adhesion kinase and p130Cas
14. Suppression of matrix metalloproteinase-2 gene expression and invasion in human glioma cells by MMAC/PTEN
15. PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein
16. Identification of a PTEN mutation in a family with Cowden syndrome and Bannayan-Zonana syndrome
17. The expression profile for the tumour suppressor gene PTEN and associated polymorphic markers
18. Identification and characterization of a novel transcript of the murine growth hormone receptor gene exhibiting development- and tissue-specific expression
19. Growth suppression of human head and neck cancer cells by the introduction of a wild-type p53 gene via a recombinant adenovirus
20. Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism
21. Regulation of PTEN transcription by p53
22. The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling
23. Sp1 and egr-1 have opposing effects on the regulation of the rat Pgp2/mdr1b gene
24. Transforming growth factor beta activates the promoter of cyclin-dependent kinase inhibitor p15INK4B through an Sp1 consensus site