Differences in mutational patterns between rheumatoid factors in health and disease are related to variable heavy chain family and germ-line gene usage

European Journal of Immunology

Volumn 27, Issue 3, 1997, Pages 735-741

  Børretzen, Marie ^a   Chapman, Caroline ^b   Natvig, Jacob B ^a   Thompson, Keith M ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Affinity maturation; Hypermutation; IgM; Rheumatoid factor; Variable genes

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; RHEUMATOID FACTOR;

ANIMAL CELL; ARTICLE; COMPLEMENTARITY DETERMINING REGION; DISSOCIATION CONSTANT; GENE; GERM LINE; IMMUNOGLOBULIN GENE; MOUSE; MUTATION RATE; NONHUMAN; PRIORITY JOURNAL; RHEUMATIC DISEASE;

AMINO ACID SEQUENCE; ANTIBODY AFFINITY; ANTIBODY DIVERSITY; ARTHRITIS, RHEUMATOID; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN M; IMMUNOGLOBULIN MU-CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR SEQUENCE DATA; MUTATION; RHEUMATOID FACTOR; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0031039486     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.1830270323     Document Type: Article

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