Syntaxin-3 and Syntaxin-1A inhibit L-type calcium channel activity, insulin biosynthesis and exocytosis in beta-cell lines

Diabetologia

Volumn 45, Issue 2, 2002, Pages 231-241

  Kang, Y ^a   Huang, X ^a   Pasyk, E A ^a   Ji, J ^a   Holz, G G ^b   Wheeler, M B ^a   Tsushima, R G ^a   Gaisano, H Y ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b NEW YORK UNIVERSITY   (United States)

Author keywords

Insulin biosynthesis; Insulin secretion; SNAREs; Syntaxin; Voltage dependent Ca2+ channels

Indexed keywords

CALCIUM CHANNEL L TYPE; INSULIN; SYNTAXIN; SYNTAXIN 1A; SYNTAXIN 2; SYNTAXIN 3; SYNTAXIN 4; UNCLASSIFIED DRUG;

ANIMAL CELL; CONFERENCE PAPER; CONTROLLED STUDY; EXOCYTOSIS; GENETIC TRANSCRIPTION; INSULIN SYNTHESIS; INSULINOMA; NONHUMAN; NORTHERN BLOTTING; PANCREAS ISLET BETA CELL; PATCH CLAMP; PRIORITY JOURNAL; PROMOTER REGION; RADIOIMMUNOASSAY; RAT;

ANIMALS; ANTIGENS, SURFACE; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CELL LINE; DNA PRIMERS; EXOCYTOSIS; INSULIN; ISLETS OF LANGERHANS; MEMBRANE PROTEINS; MICE; NERVE TISSUE PROTEINS; PATCH-CLAMP TECHNIQUES; PROMOTER REGIONS (GENETICS); QA-SNARE PROTEINS; RADIOIMMUNOASSAY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SYNTAXIN 1; TRANSFECTION;

EID: 0036189610     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-001-0718-0     Document Type: Conference Paper

References (48)

1. 2+ and G-proteins
2. The synaptic vesicle cycle: A cascade of protein-protein interactions
3. SNAREpins: Minimal machinery for membrane fusion
4. Identification of the docked granule pool responsible for the first phase of glucose-stimulated insulin secretion
5. A v-SNARE participates in synaptic vesicle formation mediated by the AP3 adaptor complex
6. 2+ channels with the core complex
7. 2+ channels
8. 2+ channels in pancreatic β-cells
9. Inhibition of axonal growth by SNAP-25 antisense oligonucleotides in vitro and in vivo
10. SNARE proteins-why so many, why so few?
11. Natural history of beta cell dysfunction in NIDDM
12. Beta cell hypertrophy in fa/fa rats is associated with basal glucose hypersensitivity and reduced SNARE protein expression
13. Decreased expression of t-SNARE, syntaxin-1 and SNAP-25 in pancreatic beta cells is involved in impaired insulin secretion from diabetic GK rat islets, restoration of decreased t-SNARE proteins improves impaired insulin secretion
14. Chronic hyperglycemia triggers loss of pancreatic β-cell differentiation in an animal model of diabetes
15. Syntaxin, but not SNAP biosynthesis by rat pancreatic islets is regulated by glucose in parallel with proinsulin biosynthesis
16. Short-term regulation of insulin gene transcription by glucose
17. Glucose-stimulated insulin biosynthesis depends on insulin-stimulated gene transcription
18. Syntaxin 1A interacts with multiple exocytic proteins to regulate neurotransmitter release in vivo
19. Direct interaction of the rat unc13 homolog munc13-1 with the N-terminus of syntaxin
20. Regulation of CFTR chloride channels by syntaxin and Munc18 isoforms
21. The syntaxin family of vesicular transport receptors
22. Syntaxin 4 in 3T3-L1 adipocytes: Regulation by insulin and participation in insulin-dependent glucose transport
23. Syntaxin 4, VAMP-2, and/or VAMP-3 are functional t- and v-SNAREs for insulin-stimulated GLUT4 translocation in adipocytes
24. Distinct locations of the syntaxin family of proteins in rat pancreatic acinar cells
25. Differential localization of syntaxin isoforms in polarized MDCK cells
26. Characterization of SNARE protein expression in β-cell lines and pancreatic islets
27. Identification of synaptic proteins and their isoform mRNAs in compartments of pancreatic endocrine cells
28. 2+-induced insulin exocytosis
29. SNAP-23 is not cleaved by botulinum neurotoxin E and can replace SNAP-25 in the process of insulin secretion
30. Truncated SNAP-25 (1-197), like Botulinum neurotoxin A, can inhibit insulin secretion from HIT-T15 insulinoma cells
31. Mutations to the third cytoplasmic domain of GLP-1 receptor can functionally uncoupled from GLP-1 stimulated insulin secretion in HIT-T15 cells
32. 2+ influx and cAMP elevation overcame botulinum toxin A but not tetanus toxin inhibition of insulin exocytosis
33. Protein kinase A-dependent and -independent stimulation of exocytosis by cAMP in mouse pancreatic βcells
34. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
35. Expression and functional role of syntaxin 1/HPC-1 in pancreatic β-cells
36. 2+ in insulinoma cell line βTC3 cells
37. Evidence that syntaxin 1A is involved in storage in the secretory pathway
38. A conformational switch in syntaxin during exocytosis: Role of Munc18
39. Protein-protein interactions contributing to the specificity of intracellullar vesicular trafficking
40. Mixed and non-cognate SNARE complexes- characterization of assembly and biophysical properties
41. Characterization of Munc18c and syntaxin 4 in 3T3-L1 adipocytes
42. Botulinum neurotoxin C cleaves a single Lys-Ala bond within the C-terminal regions of syntaxins
43. +-ATPase containing tubulovesicles in gastric parietal cells
44. Endogenous syntaxins 2, 3 and 4 exhibit distinct but overlapping patterns of expression at the hepatocyte plasma membrane
45. Identification of SNAREs involved in regulated exocytosis in the pancreatic acinar cells
46. A hypothesis: SNARE-ing the mechanisms of regulated exocytosis and pathologic membrane fusions in the pancreatic acinar cell
47. Compound exocytosis in voltage-clamped mouse pancreatic b-cells revealed by carbon fibre amperometry
48. Polarized sorting of viral glycoproteins to the axon and dendrites of hippocampal neurons in culture