-
1
-
-
0034523345
-
Phylogeny of the serpin superfamily: Implications of patterns of amino acid conservation for structure and function
-
Irving JA, Pike RN, Lesk AM & Whisstock JC (2000) Phylogeny of the serpin superfamily: implications of patterns of amino acid conservation for structure and function. Genome Res 10, 1845-1864.
-
(2000)
Genome Res
, vol.10
, pp. 1845-1864
-
-
Irving, J.A.1
Pike, R.N.2
Lesk, A.M.3
Whisstock, J.C.4
-
2
-
-
1642464622
-
Evolutionary families of peptidase inhibitors
-
Rawlings ND, Tolle DP & Barrett AJ (2004) Evolutionary families of peptidase inhibitors. Biochem J 378, 705-716.
-
(2004)
Biochem J
, vol.378
, pp. 705-716
-
-
Rawlings, N.D.1
Tolle, D.P.2
Barrett, A.J.3
-
3
-
-
0037066736
-
Inhibitory activity of a heterochromatin-associated serpin (MENT) against papain-like cysteine proteinases affects chromatin structure and blocks cell proliferation
-
Irving JA, Shushanov SS, Pike RN, Popova EY, Bromme D, Coetzer TH, Bottomley SP, Boulynko IA, Grigoryev SA & Whisstock JC (2002) Inhibitory activity of a heterochromatin-associated serpin (MENT) against papain-like cysteine proteinases affects chromatin structure and blocks cell proliferation. J Biol Chem 277, 13192-13201.
-
(2002)
J Biol Chem
, vol.277
, pp. 13192-13201
-
-
Irving, J.A.1
Shushanov, S.S.2
Pike, R.N.3
Popova, E.Y.4
Bromme, D.5
Coetzer, T.H.6
Bottomley, S.P.7
Boulynko, I.A.8
Grigoryev, S.A.9
Whisstock, J.C.10
-
4
-
-
0026728952
-
Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme
-
Ray CA, Black RA, Kronheim SR, Greenstreet TA, Sleath PR, Salvesen GS & Pickup DJ (1992) Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme. Cell 69, 597-604.
-
(1992)
Cell
, vol.69
, pp. 597-604
-
-
Ray, C.A.1
Black, R.A.2
Kronheim, S.R.3
Greenstreet, T.A.4
Sleath, P.R.5
Salvesen, G.S.6
Pickup, D.J.7
-
5
-
-
0032506139
-
The reactive site loop of the serpin SCCA1 is essential for cysteine proteinase inhibition
-
Schick C, Bromme D, Bartuski AJ, Uemura Y, Schechter NM & Silverman GA (1998) The reactive site loop of the serpin SCCA1 is essential for cysteine proteinase inhibition. Proc Natl Acad Sci USA 95, 13465-13470.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 13465-13470
-
-
Schick, C.1
Bromme, D.2
Bartuski, A.J.3
Uemura, Y.4
Schechter, N.M.5
Silverman, G.A.6
-
6
-
-
0029914132
-
A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier a is present in cytotoxic lymphocytes
-
Sun J, Bird CH, Sutton V, McDonald L, Coughlin PB, De Jong TA, Trapani JA & Bird PI (1996) A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes. J Biol Chem 271, 27802-27809.
-
(1996)
J Biol Chem
, vol.271
, pp. 27802-27809
-
-
Sun, J.1
Bird, C.H.2
Sutton, V.3
McDonald, L.4
Coughlin, P.B.5
De Jong, T.A.6
Trapani, J.A.7
Bird, P.I.8
-
7
-
-
0035823595
-
The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature
-
Silverman GA, Bird PI, Carrell RW, Church FC, Coughlin PB, Gettins PG, Irving JA, Lomas DA, Luke CJ, Moyer RW, Pemberton PA, Remold-O'Donnell E, Salvesen GS, Travis J & Whisstock JC (2001) The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature. J Biol Chem 276, 33293-33296.
-
(2001)
J Biol Chem
, vol.276
, pp. 33293-33296
-
-
Silverman, G.A.1
Bird, P.I.2
Carrell, R.W.3
Church, F.C.4
Coughlin, P.B.5
Gettins, P.G.6
Irving, J.A.7
Lomas, D.A.8
Luke, C.J.9
Moyer, R.W.10
Pemberton, P.A.11
Remold-O'Donnell, E.12
Salvesen, G.S.13
Travis, J.14
Whisstock, J.C.15
-
8
-
-
0034687422
-
Structure of a serpin-protease complex shows inhibition by deformation
-
Huntington JA, Read RJ & Carrell RW (2000) Structure of a serpin-protease complex shows inhibition by deformation. Nature 407, 923-926.
-
(2000)
Nature
, vol.407
, pp. 923-926
-
-
Huntington, J.A.1
Read, R.J.2
Carrell, R.W.3
-
9
-
-
0034000728
-
Cleaved antitrypsin polymers at atomic resolution
-
Dunstone MA, Dai W, Whisstock JC, Rossjohn J, Pike RN, Feil SC, Le Bonniec BF, Parker MW & Bottomley SP (2000) Cleaved antitrypsin polymers at atomic resolution. Protein Sci 9, 417-420.
-
(2000)
Protein Sci
, vol.9
, pp. 417-420
-
-
Dunstone, M.A.1
Dai, W.2
Whisstock, J.C.3
Rossjohn, J.4
Pike, R.N.5
Feil, S.C.6
Le Bonniec, B.F.7
Parker, M.W.8
Bottomley, S.P.9
-
10
-
-
0032589794
-
A 2.6 Å structure of a serpin polymer and implications for conformational disease
-
Huntington JA, Pannu NS, Hazes B, Read RJ, Lomas DA & Carrell RW (1999) A 2.6 Å structure of a serpin polymer and implications for conformational disease. J Mol Biol 293, 449-455.
-
(1999)
J Mol Biol
, vol.293
, pp. 449-455
-
-
Huntington, J.A.1
Pannu, N.S.2
Hazes, B.3
Read, R.J.4
Lomas, D.A.5
Carrell, R.W.6
-
11
-
-
0026755363
-
The mechanism of Z alpha 1-antitrypsin accumulation in the liver
-
Lomas DA, Evans DL, Finch JT & Carrell RW (1992) The mechanism of Z alpha 1-antitrypsin accumulation in the liver. Nature 357, 605-607.
-
(1992)
Nature
, vol.357
, pp. 605-607
-
-
Lomas, D.A.1
Evans, D.L.2
Finch, J.T.3
Carrell, R.W.4
-
12
-
-
0036789017
-
Serpinopathies and the conformational dementias
-
Lomas DA & Carrell RW (2002) Serpinopathies and the conformational dementias. Nat Rev Genet 3, 759-768.
-
(2002)
Nat Rev Genet
, vol.3
, pp. 759-768
-
-
Lomas, D.A.1
Carrell, R.W.2
-
13
-
-
23944454401
-
The heparin binding site of antithrombin is crucial for antiangiogenic activity
-
Zhang W, Swanson R, Izaguirre G, Xiong Y, Lau LF & Olson ST (2005) The heparin binding site of antithrombin is crucial for antiangiogenic activity. Blood 106, 1621-1628.
-
(2005)
Blood
, vol.106
, pp. 1621-1628
-
-
Zhang, W.1
Swanson, R.2
Izaguirre, G.3
Xiong, Y.4
Lau, L.F.5
Olson, S.T.6
-
14
-
-
4344590703
-
Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin
-
Li W, Johnson DJ, Esmon CT & Huntington JA (2004) Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin. Nat Struct Mol Biol 11, 857-862.
-
(2004)
Nat Struct Mol Biol
, vol.11
, pp. 857-862
-
-
Li, W.1
Johnson, D.J.2
Esmon, C.T.3
Huntington, J.A.4
-
15
-
-
0026475179
-
Antithrombin III deficiency and cerebrovascular accidents in young adults
-
Graham JA, Daly HM & Carson PJ (1992) Antithrombin III deficiency and cerebrovascular accidents in young adults. J Clin Pathol 45, 921-922.
-
(1992)
J Clin Pathol
, vol.45
, pp. 921-922
-
-
Graham, J.A.1
Daly, H.M.2
Carson, P.J.3
-
16
-
-
0034283174
-
Conformational changes in serpins. II. The mechanism of activation of anti-thrombin by heparindagger
-
Whisstock JC, Pike RN, Jin L, Skinner R, Pei XY, Carrell RW & Lesk AM (2000) Conformational changes in serpins. II. The mechanism of activation of anti-thrombin by heparindagger. J Mol Biol 301, 1287-1305.
-
(2000)
J Mol Biol
, vol.301
, pp. 1287-1305
-
-
Whisstock, J.C.1
Pike, R.N.2
Jin, L.3
Skinner, R.4
Pei, X.Y.5
Carrell, R.W.6
Lesk, A.M.7
-
17
-
-
20044373225
-
The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition
-
Fulton KF, Buckle AM, Cabrita LD, Irving JA, Butcher RE, Smith I, Reeve S, Lesk AM, Bottomley SP, Rossjohn J & Whisstock JC (2005) The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition. J Biol Chem 280, 8435-8442.
-
(2005)
J Biol Chem
, vol.280
, pp. 8435-8442
-
-
Fulton, K.F.1
Buckle, A.M.2
Cabrita, L.D.3
Irving, J.A.4
Butcher, R.E.5
Smith, I.6
Reeve, S.7
Lesk, A.M.8
Bottomley, S.P.9
Rossjohn, J.10
Whisstock, J.C.11
-
18
-
-
1542496192
-
The 1.5 Å crystal structure of a prokaryote serpin: Controlling conformational change in a heated environment
-
Irving JA, Cabrita LD, Rossjohn J, Pike RN, Bottomley SP & Whisstock JC (2003) The 1.5 Å crystal structure of a prokaryote serpin: controlling conformational change in a heated environment. Structure (Camb) 11, 387-397.
-
(2003)
Structure (Camb)
, vol.11
, pp. 387-397
-
-
Irving, J.A.1
Cabrita, L.D.2
Rossjohn, J.3
Pike, R.N.4
Bottomley, S.P.5
Whisstock, J.C.6
-
19
-
-
1842853550
-
Serpins in prokaryotes
-
Irving JA, Steenbakkers PJ, Lesk AM, Op den Camp HJ, Pike RN & Whisstock JC (2002) Serpins in prokaryotes. Mol Biol Evol 19, 1881-1890.
-
(2002)
Mol Biol Evol
, vol.19
, pp. 1881-1890
-
-
Irving, J.A.1
Steenbakkers, P.J.2
Lesk, A.M.3
Op Den Camp, H.J.4
Pike, R.N.5
Whisstock, J.C.6
-
20
-
-
22744455144
-
Lack of involvement of strand s1′A of the viral serpin CrmA in anti-apoptotic or caspase-inhibitory functions
-
Simonovic M, Denault JB, Salvesen GS, Volz K & Gettins PG (2005) Lack of involvement of strand s1′A of the viral serpin CrmA in anti-apoptotic or caspase-inhibitory functions. Arch Biochem Biophys 440, 1-9.
-
(2005)
Arch Biochem Biophys
, vol.440
, pp. 1-9
-
-
Simonovic, M.1
Denault, J.B.2
Salvesen, G.S.3
Volz, K.4
Gettins, P.G.5
-
21
-
-
0032579273
-
Chromatin structure in granulocytes. A link between tight compaction and accumulation of a heterochromatin-associated protein (MENT)
-
Grigoryev SA & Woodcock CL (1998) Chromatin structure in granulocytes. A link between tight compaction and accumulation of a heterochromatin-associated protein (MENT). J Biol Chem 273, 3082-3089.
-
(1998)
J Biol Chem
, vol.273
, pp. 3082-3089
-
-
Grigoryev, S.A.1
Woodcock, C.L.2
-
22
-
-
11244315121
-
Crystal structure of human maspin, a serpin with antitumor properties: Reactive center loop of maspin is exposed but constrained
-
Al-Ayyoubi M, Gettins PG & Volz K (2004) Crystal structure of human maspin, a serpin with antitumor properties: reactive center loop of maspin is exposed but constrained. J Biol Chem 279, 55540-55544.
-
(2004)
J Biol Chem
, vol.279
, pp. 55540-55544
-
-
Al-Ayyoubi, M.1
Gettins, P.G.2
Volz, K.3
-
23
-
-
20444488806
-
The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix
-
Law RH, Irving JA, Buckle AM, Ruzyla K, Buzza M, Bashtannyk-Puhalovich TA, Beddoe TC, Nguyen K, Worrall DM, Bottomley SP, Bird PI, Rossjohn J & Whisstock JC (2005) The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix. J Biol Chem 280, 22356-22364.
-
(2005)
J Biol Chem
, vol.280
, pp. 22356-22364
-
-
Law, R.H.1
Irving, J.A.2
Buckle, A.M.3
Ruzyla, K.4
Buzza, M.5
Bashtannyk-Puhalovich, T.A.6
Beddoe, T.C.7
Nguyen, K.8
Worrall, D.M.9
Bottomley, S.P.10
Bird, P.I.11
Rossjohn, J.12
Whisstock, J.C.13
-
24
-
-
2342422643
-
Maspin plays an essential role in early embryonic development
-
Gao F, Shi HY, Daughty C, Cella N & Zhang M (2004) Maspin plays an essential role in early embryonic development. Development 131, 1479-1489.
-
(2004)
Development
, vol.131
, pp. 1479-1489
-
-
Gao, F.1
Shi, H.Y.2
Daughty, C.3
Cella, N.4
Zhang, M.5
-
25
-
-
0041856173
-
Sufficiency of the reactive site loop of maspin for induction of cell-matrix adhesion and inhibition of cell invasion. Conversion of ovalbumin to a maspin-like molecule
-
Ngamkitidechakul C, Warejcka DJ, Burke JM, O'Brien WJ & Twining SS (2003) Sufficiency of the reactive site loop of maspin for induction of cell-matrix adhesion and inhibition of cell invasion. Conversion of ovalbumin to a maspin-like molecule. J Biol Chem 278, 31796-31806.
-
(2003)
J Biol Chem
, vol.278
, pp. 31796-31806
-
-
Ngamkitidechakul, C.1
Warejcka, D.J.2
Burke, J.M.3
O'Brien, W.J.4
Twining, S.S.5
-
26
-
-
10244232835
-
Antithrombotic activity of dermatan sulfate in heparin cofactor II-deficient mice
-
Vicente CP, He L, Pavao MS & Tollefsen DM (2004) Antithrombotic activity of dermatan sulfate in heparin cofactor II-deficient mice. Blood 104, 3965-3970.
-
(2004)
Blood
, vol.104
, pp. 3965-3970
-
-
Vicente, C.P.1
He, L.2
Pavao, M.S.3
Tollefsen, D.M.4
-
27
-
-
18644365116
-
A direct role for C1 inhibitor in regulation of leukocyte adhesion
-
Cai S, Dole VS, Bergmeier W, Scafidi J, Feng H, Wagner DD & Davis AE III (2005) A direct role for C1 inhibitor in regulation of leukocyte adhesion. J Immunol 174, 6462-6466.
-
(2005)
J Immunol
, vol.174
, pp. 6462-6466
-
-
Cai, S.1
Dole, V.S.2
Bergmeier, W.3
Scafidi, J.4
Feng, H.5
Wagner, D.D.6
Davis III, A.E.7
-
28
-
-
2442485932
-
SRP-2 is a cross-class inhibitor that participates in post-embryonic development of the nematode Caenorhabditis elegans: Initial characterization of the clade L serpins
-
Pak SC, Kumar V, Tsu C, Luke CJ, Askew YS, Askew DJ, Mills DR, Bromme D & Silverman GA (2004) SRP-2 is a cross-class inhibitor that participates in post-embryonic development of the nematode Caenorhabditis elegans: initial characterization of the clade L serpins. J Biol Chem 279, 15448-15459.
-
(2004)
J Biol Chem
, vol.279
, pp. 15448-15459
-
-
Pak, S.C.1
Kumar, V.2
Tsu, C.3
Luke, C.J.4
Askew, Y.S.5
Askew, D.J.6
Mills, D.R.7
Bromme, D.8
Silverman, G.A.9
-
29
-
-
0345094925
-
A serpin regulates dorsal-ventral axis formation in the Drosophila embryo
-
Ligoxygakis P, Roth S & Reichhart JM (2003) A serpin regulates dorsal-ventral axis formation in the Drosophila embryo. Curr Biol 13, 2097-2102.
-
(2003)
Curr Biol
, vol.13
, pp. 2097-2102
-
-
Ligoxygakis, P.1
Roth, S.2
Reichhart, J.M.3
-
30
-
-
17544381846
-
A protein family under 'stress' - Serpin stability, folding and misfolding
-
Devlin GL & Bottomley SP (2005) A protein family under 'stress' - serpin stability, folding and misfolding. Front Biosci 10, 288-299.
-
(2005)
Front Biosci
, vol.10
, pp. 288-299
-
-
Devlin, G.L.1
Bottomley, S.P.2
-
31
-
-
15044339964
-
Intraneuronal a beta, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer's disease
-
Crowther DC, Kinghorn KJ, Miranda E, Page R, Curry JA, Duthie FA, Gubb DC & Lomas DA (2005) Intraneuronal A beta, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer's disease. Neuroscience 132, 123-135.
-
(2005)
Neuroscience
, vol.132
, pp. 123-135
-
-
Crowther, D.C.1
Kinghorn, K.J.2
Miranda, E.3
Page, R.4
Curry, J.A.5
Duthie, F.A.6
Gubb, D.C.7
Lomas, D.A.8
-
32
-
-
4444332086
-
How small peptides block and reverse serpin polymerisation
-
Zhou A, Stein PE, Huntington JA, Sivasothy P, Lomas DA & Carrell RW (2004) How small peptides block and reverse serpin polymerisation. J Mol Biol 342, 931-941.
-
(2004)
J Mol Biol
, vol.342
, pp. 931-941
-
-
Zhou, A.1
Stein, P.E.2
Huntington, J.A.3
Sivasothy, P.4
Lomas, D.A.5
Carrell, R.W.6
-
33
-
-
0038053035
-
Serpin polymerization is prevented by a hydrogen bond network that is centered on His-334 and stabilized by glycerol
-
Zhou A, Stein PE, Huntington JA & Carrell RW (2003) Serpin polymerization is prevented by a hydrogen bond network that is centered on His-334 and stabilized by glycerol. J Biol Chem 278, 15116-15122.
-
(2003)
J Biol Chem
, vol.278
, pp. 15116-15122
-
-
Zhou, A.1
Stein, P.E.2
Huntington, J.A.3
Carrell, R.W.4
-
34
-
-
0034634617
-
Characterization of cucurbita maxima phloem serpin-1 (CmPS-1). A developmentally regulated elastase inhibitor
-
Yoo BC, Aoki K, Xiang Y, Campbell LR, Hull RJ, Xoconostle-Cazares B, Monzer J, Lee JY, Ullman DE & Lucas WJ (2000) Characterization of cucurbita maxima phloem serpin-1 (CmPS-1). A developmentally regulated elastase inhibitor. J Biol Chem 275, 35122-35128.
-
(2000)
J Biol Chem
, vol.275
, pp. 35122-35128
-
-
Yoo, B.C.1
Aoki, K.2
Xiang, Y.3
Campbell, L.R.4
Hull, R.J.5
Xoconostle-Cazares, B.6
Monzer, J.7
Lee, J.Y.8
Ullman, D.E.9
Lucas, W.J.10
-
35
-
-
0034763848
-
The structure of a Michaelis serpin-protease complex
-
Ye S, Cech AL, Belmares R, Bergstrom RC, Tong Y, Corey DR, Kanost MR & Goldsmith EJ (2001) The structure of a Michaelis serpin-protease complex. Nat Struct Biol 8, 979-983.
-
(2001)
Nat Struct Biol
, vol.8
, pp. 979-983
-
-
Ye, S.1
Cech, A.L.2
Belmares, R.3
Bergstrom, R.C.4
Tong, Y.5
Corey, D.R.6
Kanost, M.R.7
Goldsmith, E.J.8
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