The 1.5 Å crystal structure of a prokaryote serpin: Controlling conformational change in a heated environment

Structure

Volumn 11, Issue 4, 2003, Pages 387-397

  Irving, James A ^a,b   Cabrita, Lisa D ^a   Rossjohn, Jamie ^a   Pike, Robert N ^a   Bottomley, Stephen P ^a   Whisstock, James C ^a  

^a Department of Physiology School of Biomedical Sciences   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

Folding; Polymerization; Proteinase inhibitor; Serpin; Thermostability

Indexed keywords

ALPHA 1 ANTITRYPSIN; PROTEINASE; SERINE PROTEINASE INHIBITOR; THERMOPIN; UNCLASSIFIED DRUG; BACTERIAL PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; BETA SHEET; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; GENOME; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROKARYOTE; PROTEIN FAMILY; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN STABILITY; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; THERMOPHILIC BACTERIUM; THERMOSTABILITY; ACTINOMYCETALES; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME STABILITY; GENETICS; HEAT; HUMAN; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION; PROTEIN DENATURATION; SEQUENCE ALIGNMENT; X RAY CRYSTALLOGRAPHY;

BACTERIA (MICROORGANISMS); PROKARYOTA;

ACTINOMYCETALES; ALPHA 1-ANTITRYPSIN; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; CRYSTALLOGRAPHY, X-RAY; ENZYME STABILITY; HEAT; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN DENATURATION; SEQUENCE ALIGNMENT; SERINE PROTEINASE INHIBITORS; SERPINS;

EID: 1542496192     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(03)00057-1     Document Type: Article

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