The reactive site loop of the serpin SCCA1 is essential for cysteine proteinase inhibition

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 23, 1998, Pages 13465-13470

  Schick, Charles ^a   Brömme, Dieter ^b   Bartuski, Allison J ^a   Uemura, Yoshiki ^a   Schechter, Norman M ^c   Silverman, Gary A ^a,d  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHYMOTRYPSIN INHIBITOR; CYSTEINE PROTEINASE; SERINE PROTEINASE INHIBITOR; SQUAMOUS CELL CARCINOMA ANTIGEN;

ARTICLE; CONFORMATIONAL TRANSITION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; NONHUMAN; POINT MUTATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REGULATORY MECHANISM; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, NEOPLASM; BINDING SITES; ESCHERICHIA COLI; HUMANS; MOLECULAR SEQUENCE DATA; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; SERPINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032506139     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.23.13465     Document Type: Article

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