Angiogenic molecule expression is downregulated in effusions from breast cancer patients

Breast Cancer Research and Treatment

Volumn 94, Issue 1, 2005, Pages 71-80

  Konstantinovsky, Sophya ^a   Nielsen, Søren ^b   Vyberg, Mogens ^b   Kvalheim, Gunnar ^c   Nesland, Jahn M ^c   Reich, Reuven ^a,d   Davidson, Ben ^c  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b AALBORG UNIVERSITY HOSPITAL   (Denmark)

^c UNIVERSITY OF OSLO   (Norway)

^d HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Angiogenic factors; Breast carcinoma; Ets transcription factors; Serous effusions; Survival

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; CD51 ANTIGEN; INTERLEUKIN 8; MESSENGER RNA; TRANSCRIPTION FACTOR ETS 1; TRANSCRIPTION FACTOR PEA3; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

ADULT; AGED; ANGIOGENESIS; ARTICLE; BREAST CANCER; CANCER DIAGNOSIS; CANCER GROWTH; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; PHENOTYPE; PLEURA EFFUSION; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOLID TUMOR;

ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; ANGIOGENIC PROTEINS; BREAST NEOPLASMS; CASE-CONTROL STUDIES; DISEASE-FREE SURVIVAL; DOWN-REGULATION; FEMALE; FIBROBLAST GROWTH FACTOR 2; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTEGRIN ALPHAV; INTERLEUKIN-8; MIDDLE AGED; PLEURAL EFFUSION, MALIGNANT; PROTO-ONCOGENE PROTEINS C-ETS; RNA, MESSENGER; SURVIVAL RATE; TRANSCRIPTION FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 26244439053     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10549-005-7328-3     Document Type: Article

References (61)

1. N Weidner JP Semple WR Welch J Folkman 1991 Tumor angiogenesis and metastasis - correlation in invasive breast carcinoma N Engl J Med 324 1 8
2. R Heimann D Ferguson S Gray S Hellman 1998 Assessment of intratumoral vascularization (angiogenesis) in breast cancer prognosis Breast Cancer Res Treat 52 147 158
3. P Viacava AG Naccarato G Bocci G Fanelli P Aretini A Lonobile G Evangelista G Montruccoli G Bevilacqua 2004 Angiogenesis and VEGF expression in pre-invasive lesions of the human breast J Pathol 204 140 146
4. Y Cao GP Paner LB Kahn PB Rajan 2004 Noninvasive carcinoma of the breast: angiogenesis and cell proliferation Arch Pathol Lab Med 128 893 896
5. G Gasparini 2001 Clinical significance of determination of surrogate markers of angiogenesis in breast cancer Crit Rev Oncol Hematol 37 97 114
6. J Sottile 2004 Regulation of angiogenesis by extracellular matrix Biochim Biophys Acta 1654 13 22
7. HF Dvorak LF Brown M Detmar AM Dvorak 1995 Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis Am J Pathol 146 1029 1039
8. M Toi K Inada S Hoshina H Suzuki S Kondo T Tominaga 1995 Vascular endothelial growth factor and platelet-derived endothelial cell growth factor are frequently coexpressed in highly vascularized human breast cancer Clin Cancer Res 1 961 964
9. SC Heffelfinger MA Miller R Yassin R Gear 1999 Angiogenic growth factors in preinvasive breast disease Clin Cancer Res 5 2867 2876
10. G Gasparini M Toi M Gion P Verderio R Dittadi M Hanatani I Matsubara O Vinante E Bonoldi P Boracchi C Gatti H Suzuki T Tominaga 1997 Prognostic significance of vascular endothelial growth factor protein in node-negative breast carcinoma J Natl Cancer Inst 89 139 147
11. M. Toi S Hoshina T Takayanagi T Tominaga 1994 Association of endothelial growth factor expression with tumor angiogenesis and with early relapse in primary breast cancer Jpn J Cancer Res 85 1045 1049
12. M Jaye J Schlessinger CA Dionne 1992 Fibroblast growth factor receptor tyrosine kinases: molecular analysis and signal transduction Biochem Biophys Acta 1135 185 199
13. R Colomer J Aparicio S Montero C Guzman L Larrodera H Cortes-Funes 1997 Low levels of basic fibroblast growth factor (bFGF) are associated with a poor prognosis in human breast carcinoma Br J Cancer 76 1215 1220
14. A Faridi C Rudlowski S Biesterfeld S Schuh W Rath W Schroder 2002 Long-term follow-up and prognostic significance of angiogenic basic fibroblast growth factor (bFGF) expression in patients with breast cancer Pathol Res Pract 198 1 5
15. K Smith SB Fox R Whitehouse M Taylor M Greenall J Clarke AL Harris 1999 Upregulation of basic fibroblast growth factor in breast carcinoma and its relationship to vascular density, oestrogen receptor, epidermal growth factor receptor and survival Ann Oncol 10 707 713
16. U Eppenberger W Kueng JM Schlaeppi JL Roesel C Benz H Mueller A Matter M Zuber K Luescher M Litschgi M Schmitt JA Foekens S Eppenberger-Castori 1998 Markers of tumor angiogenesis and proteolysis independently define high-and low-risk subsets of node-negative breast cancer patients J Clin Oncol 16 3129 3136
17. M Relf S LeJeune PA Scott S Fox K Smith R Leek A Moghaddam R Whitehouse R Bicknell AL Harris 1997 Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis Cancer Res 57 963 969
18. AE Koch PJ Polverini SL Kunkel LA Harlow LA DiPietro VM Elner SG Elner RM Strieter 1992 Interleukin-8 as a macrophage-derived mediator of angiogenesis Science 258 1798 1801
19. LJ Miller SH Kurtzman Y Wang KH Anderson RR Lindquist DL Kreutzer 1998 Expression of interleukin-8 receptors on tumor cells and vascular endothelial cells in human breast cancer tissue Anticancer Res 18 77 81
20. RM Strieter SL Kunkel VM Elner CL Martonyi AE Koch PJ Polverini SG Elner 1992 Interleukin-8. A corneal factor that induces neovascularization Am J Pathol 141 1279 1284
21. K Xie 2001 Interleukin-8 and human cancer biology Cytokine and Growth Factor Rev 12 375 391
22. LS Kim S Huang W Lu DC Lev JE Price 2004 Vascular endothelial growth factor expression promotes the growth of breast cancer brain metastases in nude mice Clin Exp Metastasis 21 107 118
23. JE De Larco BR Wuertz KA Rosner SA Erickson DE Gamache JC Manivel LT Furcht 2001 A potential role for interleukin-8 in the metastatic phenotype of breast carcinoma cells Am J Pathol 158 639 646
24. AR Green VL Green MC White V Speirs 1997 Expression of cytokine messenger RNA in normal and neoplastic human breast tissue: identification of interleukin-8 as a potential regulatory factor in breast tumours Int J Cancer 72 937 941
25. T Yokoe Y Iino H Takei J Horiguchi Y Koibuchi M Maemura S Ohwada Y Morishita 1997 Changes of cytokines and thyroid function in patients with recurrent breast cancer Anticancer Res 17 695 699
26. FH Hausheer JW Yarbro 1985 Diagnosis and treatment of malignant pleural effusion Semin Oncol 12 54 75
27. E Martinez-Moragon J Aparicio J Sanchis R Menendez M Cruz Rogado F Sanchis 1998 Malignant pleural effusion: prognostic factors for survival and response to chemical pleurodesis in a series of 120 cases Respiration 65 108 113
28. JD Wilkes P Fidias L Vaickus RP Perez 1995 Malignancy-related pericardial effusion. 127 cases from the Roswell Park Center Institute Cancer 76 1377 1387
29. M Dieterich SN Goodman RR Rojas-Corona AB Emralino D Jimenez-Joseph ME Sherman 1994 Multivariate analysis of prognostic features in malignant pleural effusions from breast cancer patients Acta Cytol 38 945 952
30. AK Banerjee I Willetts JF Robertson RW Blamey 1994 Pleural effusion in breast cancer: a review of the Nottingham experience Eur J Surg Oncol 20 33 36
31. B Davidson R Reich P Lazarovici VA Flørenes S Nielsen JM Nesland 2004 Altered expression and activation of the nerve growth factor receptors TrkA and p75 provides the first evidence of tumor progression to effusion in breast carcinoma Breast Cancer Res Treat 83 119 128
32. B Davidson S Konstantinovsky S Nielsen HP Dong A Berner M Vyberg R Reich 2004 Altered expression of metastasis-associated and regulatory molecules in effusions from breast cancer patients- a novel model for tumor progression Clin Cancer Res 10 7335 7346
33. JD Hood DA Cheresh 2002 Role of integrins in cell invasion and migration Nature Rev Cancer 2 91 100
34. J Chen C Baskerville Q Han ZK Pan S Huang 2001 αv integrin, p38 mitogen-activated protein kinase, and urokinase plasminogen activator are functionally linked in invasive breast cancer cells J Biol Chem 276 47901 47905
35. NC Wong BM Mueller CF Barbas P Ruminski V Quaranta EC Lin JW Smith 1998 αv integrins mediate adhesion and migration of breast carcinoma lines Clin Exp Metastasis 16 50 61
36. B Davidson B Risberg G Kristensen G Kvalheim E Emilsen A Bjåmer A Berner 1999 Detection of cancer cells in effusions from patients diagnosed with gynecological malignancies. Evaluation of five epithelial markers Virchows Arch 435 43 49
37. B Davidson S Nielsen J Christensen P Asschenfeldt A Berner B Risberg P Johansen 2001 The role of Desmin and N-cadherin in effusion cytology. A comparative study using established markers of mesothelial and epithelial cells Am J Surg Pathol 25 1405 1412
38. GF Greene Y Kitadai CA Pettaway AC von Eschenbach CD Bucana IJ Fidler 1997 Correlation of metastasis-related gene expression with metastatic potential in human prostate carcinoma cells implanted in nude mice using an in situ messenger RNA hybridization technique Am J Pathol 150 1571 1582
39. JA Reed LJ Manahan CS Parks DJ Brigati 1992 Complete one-hour immunocytochemistry based on capillary action Biotechniques. 13 434 443
40. B Davidson I Goldberg WH Gotlieb J Kopolovic G Ben-Baruch JM Nesland A Berner M Bryne R Reich 1999 High levels of MMP-2, MMP-9, MT1-MMP and TIMP-2 mRNA correlate with poor survival in ovarian carcinoma Clin Exp Metastasis 17 799 808
41. C Iwasaka K Tanaka M Abe Y Sato 1996 Ets-1 regulates angiogenesis by inducing the expression of urokinase-type plasminogen activator and matrix metalloproteinase-1 and the migration of vascular endothelial cells J Cell Physiol 169 522 531
42. B Davidson 2004 Malignant effusions: from diagnosis to biology Diagn Cytopathol 31 246 254
43. B Davidson R Reich J Kopolovic A Berner JM Nesland GB Kristensen CG Trope M Bryne B Risberg G van de Putte I Goldberg 2002 Interleukin-8 and vascular endothelial growth factor mRNA and protein levels are down-regulated in ovarian carcinoma cells in serous effusions Clin Exp Metastasis 19 135 144
44. B Davidson L Vintman E Zcharia C Bedrossian A Berner S Nielsen N Ilan I Vlodavsky R Reich 2004 Heparanase and basic fibroblast growth factor are co-expressed in malignant mesothelioma Clin Exp Metastasis 21 469 476
45. BK Zebrowski S Yano W Liu RM Shaheen DJ Hicklin JB Putnam Jr LM Ellis 1999 Vascular endothelial growth factor levels and induction of permeability in malignant pleural effusions Clin Cancer Res 5 3364 3368
46. D Cheng RM Rodriguez EA Perkett J Rogers G Bienvenu U Lappalainen RW Light 1999 Vascular endothelial growth factor in pleural fluid Chest 116 760 765
47. B Wasylyk SL Hahn A Giovane 1993 The Ets family of transcription factors Eur J Biochem 211 7 18
48. B Davidson R Reich I Goldberg WH Gotlieb J Kopolovic A Berner G Ben-Baruch M Bryne JM Nesland 2001 Ets-1 mRNA expression is a novel marker of poor survival in ovarian carcinoma Clin Cancer Res 7 551 557
49. P Borden RU Heller 1997 Transcriptional control of matrix metalloproteinases and the tissue inhibitors of matrix metalloproteinases Crit Rev Eukar Gene Exp 7 159 178
50. E Lengyel E Stepp R Gum D Boyd 1995 Involvement of a mitogen-activated protein kinase signaling pathway in the regulation of urokinase promoter activity by c-Ha-ras J Biol Chem 270 23007 23012
51. N Oda M Abe Y Sato 1999 Ets-1 converts endothelial cells to the angiogenic phenotype by inducing the expression of matrix metalloproteinases and integrin β3 J Cell Physiol 178 121 132
52. RC O'Hagan JA Hassell 1998 The PEA3 Ets transcription factor is a downstream target of the HER2/Neu receptor tyrosine kinase Oncogene 16 301 310
53. X Xing SC Wang W Xia Y Zou R Shao KY Kwong Z Yu S Zhang S Miller L Huang MC Hung 2000 The Ets protein PEA3 suppresses HER-2/neu overexpression, inhibits tumorigenesis Nature Med 6 189 195
54. FK Guerra-Vladusic EA Vladusic MS Tsai R Lupu 2001 Signaling molecules implicated in heregulin induction of growth arrest and apoptosis Oncol Rep 8 1203 1214
55. B Davidson I Goldberg WH Gotlieb J Kopolovic B Risberg G Ben-Baruch R Reich 2003 Coordinated expression of integrin subunits, matrix metalloproteinases (MMP), angiogenic genes and Ets transcription factors in advanced-stage ovarian carcinoma - A possible activation pathway? Cancer Metastasis Rev 22 103 115
56. HK Weir MJ Thun BF Hankey LA Ries HL Howe PA Wingo A Jemal E Ward RN Anderson BK Edwards 2003 Annual report to the nation on the status of cancer, 1975-2000, featuring the uses of surveillance data for cancer prevention and control J Natl Cancer Inst 95 1276 1299
57. S Elloul M Bukholt Elstrand JM Nesland CG Trope' G Kvalheim I Goldberg R Reich B Davidson 2005 Snail, Slug and Sip1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma Cancer 103 1631 1643
58. B Davidson I Goldberg WH Gotlieb J Kopolovic G Ben-Baruch JM Nesland R Reich 2002 The prognostic value of metalloproteinases and angiogenic factors in ovarian carcinoma Mol Cell Endocrinol 187 39 45
59. J Kinoshita K Kitamura S Tanaka K Sugimachi M Ishida H Saeki 2002 Clinical significance of PEA3 in human breast cancer Surgery 131 S222 S225
60. B Davidson I Goldberg WH Gotlieb J Kopolovic G Ben-Baruch R Reich 2003 PEA3 is the second Ets family transcription factor involved in tumor progression in ovarian carcinoma Clin Cancer Res 9 1412 1419
61. PN Span P Manders JJ Heuvel LV Beex CG Sweep 2003 E1AF expression levels are not associated with prognosis in human breast cancer Breast Cancer Res Treat 79 129 131