E1AF expression levels are not associated with prognosis in human breast cancer

Breast Cancer Research and Treatment

Volumn 79, Issue 1, 2003, Pages 129-131

  Span, Paul N ^a   Manders, Peggy ^a   Heuvel, Joop J T M ^a   Beex, Louk V A M ^a   Sweep, C G J ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Breast neoplasm; HER2 neu; Matrix metalloproteinases; Prognosticator; Quantitative real time RT PCR; Survival analysis

Indexed keywords

HORMONE RECEPTOR; MESSENGER RNA; ONCOPROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E1AF; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BREAST CARCINOMA; CANCER GRADING; CANCER SIZE; CONTROLLED STUDY; HISTOPATHOLOGY; HUMAN; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; ONCOGENE NEU; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION;

ADENOVIRUS E1A PROTEINS; ADULT; AGED; BREAST NEOPLASMS; CARCINOMA; HUMANS; LYMPHATIC METASTASIS; MIDDLE AGED; PROGNOSIS; PROTO-ONCOGENE PROTEINS; RECEPTOR, ERBB-2; RECEPTOR, ERBB-3; RECEPTORS, STEROID; RETROSPECTIVE STUDIES; TRANSCRIPTION FACTORS;

EID: 0038365126     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1023338424677     Document Type: Article

References (8)

1. Kaya M, Yoshida K, Higashino F, Mitaka T, Ishii S, Fujinaga K: A single ets-related transcription factor, E1AF, confers invasive phenotype on human cancer cells. Oncogene 12: 221-227, 1996
2. de Launoit Y, Chotteau-Lelievre A, Beaudoin C, Coutte L, Netzer S, Brenner C, Huvent I, Baert JL: The PEA3 group of ETS-related transcription factors. Role in breast cancer metastasis. Adv Exp Med Biol 480: 107-116, 2000
3. Benz CC, O'Hagan RC, Richter B, Scott GK, Chang CH, Xiong X, Chew K, Ljung BM, Edgerton S, Thor A, Hassell JA: HER2/neu and the Ets transcription activator PEA3 are coordinately upregulated in human breast cancer. Oncogene 15: 1513-1525, 1997
4. Shepherd TG, Kockeritz L, Szrajber MR, Muller WJ, Hassell JA: The pea3 subfamily ets genes are required for HER2/neumediated mammary oncogenesis. Curr Biol 11: 1739-1748, 2001
5. Xing X, Wang SC, Xia W, Zou Y, Shao R, Kwong KY, Yu Z, Zhang S, Miller S, Huang L, Hung MC: The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis. Nat Med 6: 189-195, 2000
6. Wang SC, Zhang L, Hortobagyi GN, Hung MC: Targeting HER2: recent developments and future directions for breast cancer patients. Semin Oncol 28: 21-29, 2001
7. Harrell Jr FE, Lee KL, Matchar DB, Reichert TA: Regression models for prognostic prediction: advantages, problems, and suggested solutions. Cancer Treat Rep 69: 1071-1077, 1985
8. Span PN, Manders P, Heuvel JJTM, Thomas CMG, Bosch RR, Beex LVAM, Sweep CGJ: Expression of the transcription factor Ets-1 is an independent prognostic marker for relapse-free survival in breast cancer Oncogene 21: 8506-8509, 2002