Pharmacokinetics of caroverine in the inner ear and its effects on cochlear function after systemic and local administrations in guinea pigs

Audiology and Neuro-Otology

Volumn 8, Issue 1, 2003, Pages 49-56

  Chen, Zhiqiang ^a,b   Duan, Maoli ^b,c   Lee, Howsung ^a   Ruan, Runsheng ^a   Ulfendahl, Mats ^b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b KAROLINSKA INSTITUTE   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Auditory brainstem response; Caroverine; Cerebrospinal fluid; Glutamate; Guinea pig; High performance liquid chromatography; Perilymph; Pharmacokinetics; Plasma; Round window membrane

Indexed keywords

AMPA RECEPTOR ANTAGONIST; CAROVERINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUDITORY RESPONSE; BRAIN STEM; CEREBROSPINAL FLUID; COCHLEA; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; FEMALE; GUINEA PIG; HEARING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INNER EAR; MALE; NONHUMAN; PERILYMPH; PLASMA; PRIORITY JOURNAL; TINNITUS;

ANIMALS; CELL MEMBRANE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EAR, MIDDLE; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; FEMALE; GUINEA PIGS; MALE; QUINOXALINES; ROUND WINDOW;

EID: 0037234961     PISSN: 14203030     EISSN: None     Source Type: Journal    
DOI: 10.1159/000067893     Document Type: Article

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