Quercetin appears in the lymph of unanesthetized rats as its phase II metabolites after administered into the stomach

FEBS Letters

Volumn 579, Issue 24, 2005, Pages 5343-5346

  Murota, Kaeko ^a   Terao, Junji ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Conjugation; Gastrointestinal absorption; Lymph; Quercetin; Rat; UGT activity

Indexed keywords

FLAVONOID; GLUCURONIDE; QUERCETIN; SULFATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DUODENUM; GASTROINTESTINAL MUCOSA; GASTROINTESTINAL TRACT; GLUCURONIDATION; JEJUNUM; LYMPH; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE; STOMACH; STOMACH ABSORPTION;

ANIMALS; DRUG ADMINISTRATION ROUTES; LYMPH; MALE; QUERCETIN; RATS; RATS, WISTAR; STOMACH;

EID: 25844526542     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2005.08.060     Document Type: Article

References (32)

1. A.Y. Sun, A. Simonyi, and G.Y. Sun The French Paradox and beyond: neuroprotective effects of polyphenols Free Radic. Biol. Med. 32 2002 314 318
2. J.A. Ross, and C.M. Kasum Dietary flavonoids: bioavailability, metabolic effects, and safety Annu. Rev. Nutr. 22 2002 19 34
3. I.C. Arts, and P.C. Hollman Polyphenols and disease risk in epidemiologic studies Am. J. Clin. Nutr. 81 2005 317S 325S
4. J.D. Lambert, J. Hong, G.Y. Yang, J. Liao, and C.S. Yang Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations Am. J. Clin. Nutr. 81 2005 284S 291S
5. C. Manach, A. Mazur, and A. Scalbert Polyphenols and prevention of cardiovascular diseases Curr. Opin. Lipidol. 16 2005 77 84
6. K. Murota, S. Shimizu, H. Chujo, J.H. Moon, and J. Terao Efficiency of absorption and metabolic conversion of quercetin and its glucosides in human intestinal cell line Caco-2 Arch. Biochem. Biophys. 384 2000 391 397
7. R.A. Walgren, J.T. Lin, R.K. Kinne, and T. Walle Cellular uptake of dietary flavonoid quercetin 4′-beta-glucoside by sodium-dependent glucose transporter SGLT1 J. Pharmacol. Exp. Ther. 294 2000 837 843
8. V. Crespy, C. Morand, C. Besson, C. Manach, C. Demigne, and C. Remesy Quercetin, but not its glycosides, is absorbed from the rat stomach J. Agric. Food Chem. 50 2002 618 621
9. V.C. de Boer, A.A. Dihal, H. van der Woude, I.C. Arts, S. Wolffram, G.M. Alink, I.M. Rietjens, J. Keijer, and P.C. Hollman Tissue distribution of quercetin in rats and pigs J. Nutr. 135 2005 1718 1725
10. J.H. Moon, R. Nakata, S. Oshima, T. Inakuma, and J. Terao Accumulation of quercetin conjugates in blood plasma after the short-term ingestion of onion by women Am. J. Physiol. Regul. Integr. Comp. Physiol. 279 2000 R461 R467
11. C. Manach, and J.L. Donovan Pharmacokinetics and metabolism of dietary flavonoids in humans Free Radic. Res. 38 2004 771 785
12. C. Manach, G. Williamson, C. Morand, A. Scalbert, and C. Remesy Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies Am. J. Clin. Nutr. 81 2005 230S 242S
13. P.C. Hollman, M.N. Bijsman, Y. van Gameren, E.P. Cnossen, J.H. de Vries, and M.B. Katan The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man Free Radic. Res. 31 1999 569 573
14. I.C. Arts, A.L. Sesink, M. Faassen-Peters, and P.C. Hollman The type of sugar moiety is a major determinant of the small intestinal uptake and subsequent biliary excretion of dietary quercetin glycosides Br. J. Nutr. 91 2004 841 847
15. A.J. Day, J.M. Gee, M.S. DuPont, I.T. Johnson, and G. Williamson Absorption of quercetin-3-glucoside and quercetin-4′-glucoside in the rat small intestine: the role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter Biochem. Pharmacol. 65 2003 1199 1206
16. S. Wolffram, M. Block, and P. Ader Quercetin-3-glucoside is transported by the glucose carrier SGLT1 across the brush border membrane of rat small intestine J. Nutr. 132 2002 630 635
17. C. Manach, C. Morand, C. Demigne, O. Texier, F. Regerat, and C. Remesy Bioavailability of rutin and quercetin in rats FEBS Lett. 409 1997 12 16
18. N. Yamamoto, J.H. Moon, T. Tsushida, A. Nagao, and J. Terao Inhibitory effect of quercetin metabolites and their related derivatives on copper ion-induced lipid peroxidation in human low-density lipoprotein Arch. Biochem. Biophys. 372 1999 347 354
19. J.A. Rothwell, A.J. Day, and M.R. Morgan Experimental determination of octanol-water partition coefficients of quercetin and related flavonoids J. Agric. Food Chem. 53 2005 4355 4360
20. J.H. Moon, T. Tsushida, K. Nakahara, and J. Terao Identification of quercetin 3-O-beta-d-glucuronide as an antioxidative metabolite in rat plasma after oral administration of quercetin Free Radic. Biol. Med. 30 2001 1274 1285
21. A.J. Day, F. Mellon, D. Barron, G. Sarrazin, M.R. Morgan, and G. Williamson Human metabolism of dietary flavonoids: identification of plasma metabolites of quercetin Free Radic. Res. 35 2001 941 952
22. S.I. Koo, and S.K. Noh Phosphatidylcholine inhibits and lysophosphatidylcholine enhances the lymphatic absorption of alpha-tocopherol in adult rats J. Nutr. 131 2001 717 722
23. P. Tso, T. Lee, and S.J. DeMichele Randomized structured triglycerides increase lymphatic absorption of tocopherol and retinol compared with the equivalent physical mixture in a rat model of fat malabsorption J. Nutr. 131 2001 2157 2163
24. K. Murota, T. Kawada, N. Matsui, M. Sakakibara, N. Takahashi, and T. Fushiki Oleyl alcohol inhibits intestinal long-chain fatty acid absorption in rats J. Nutr. Sci. Vitaminol. (Tokyo) 46 2000 302 308
25. M.K. Piskula, and J. Terao Accumulation of (-)-epicatechin metabolites in rat plasma after oral administration and distribution of conjugation enzymes in rat tissues J. Nutr. 128 1998 1172 1178
26. M.K. Piskula, and J. Terao Quercetin's solubility affects its accumulation in rat plasma after oral administration J. Agric. Food Chem. 46 1998 4313 4317
27. K. Azuma, K. Ippoushi, H. Ito, H. Higashio, and J. Terao Combination of lipids and emulsifiers enhances the absorption of orally administered quercetin in rats J. Agric. Food Chem. 50 2002 1706 1712
28. K. Azuma, K. Ippoushi, H. Ito, H. Horie, and J. Terao Enhancing effect of lipids and emulsifiers on the accumulation of quercetin metabolites in blood plasma after the short-term ingestion of onion by rats Biosci. Biotechnol. Biochem. 67 2003 2548 2555
29. S. Lesser, R. Cermak, and S. Wolffram Bioavailability of quercetin in pigs is influenced by the dietary fat content J. Nutr. 134 2004 1508 1511
30. E.L. da Silva, M.K. Piskula, N. Yamamoto, J.H. Moon, and J. Terao Quercetin metabolites inhibit copper ion-induced lipid peroxidation in rat plasma FEBS Lett. 430 1998 405 408
31. M.K. Shelby, N.J. Cherrington, N.R. Vansell, and C.D. Klaassen Tissue mRNA expression of the rat UDP-glucuronosyltransferase gene family Drug Metab. Dispos. 31 2003 326 333
32. M.G. Boersma, H. van der Woude, J. Bogaards, S. Boeren, J. Vervoort, N.H. Cnubben, M.L. van Iersel, P.J. van Bladeren, and I.M. Rietjens Regioselectivity of phase II metabolism of luteolin and quercetin by UDP-glucuronosyl transferases Chem. Res. Toxicol. 15 2002 662 670