Modulation of toll-like receptor 7 and LL-37 expression in colon and breast epithelial cells by human β-defensin-2

Allergy and Asthma Proceedings

Volumn 26, Issue 4, 2005, Pages 299-309

  Stroinigg, Nora ^a   Srivastava, Maya D ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMICROBIAL CATIONIC PEPTIDE; BETA CHEMOKINE; BETA DEFENSIN; CAP18 LIPOPOLYSACCHARIDE BINDING PROTEIN; CAP18 LIPOPOLYSACCHARIDE-BINDING PROTEIN; CCL20 PROTEIN, HUMAN; DEFB4 PROTEIN, HUMAN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN; TOLL LIKE RECEPTOR 7;

ARTICLE; BREAST; COLON; CYTOLOGY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; HUMAN; METABOLISM; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANTIMICROBIAL CATIONIC PEPTIDES; BETA-DEFENSINS; BREAST; CELL LINE, TUMOR; CHEMOKINES, CC; COLON; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIAL CELLS; HUMANS; INTERLEUKIN-8; MACROPHAGE INFLAMMATORY PROTEINS; NF-KAPPA B; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 7;

EID: 25644438337     PISSN: 10885412     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Lehrer RI, and Ganz T. Defensins of vertebrate animals. Curr Opin Immunol 14:96-102, 2002.
2. Yang D, Biragyn A, Kwak LW, and Oppenheim JJ. Mammalian defensins in immunity: More than just microbicidal. Trends Immunol 23:291-295, 2002.
3. Ouellette AJ. Mucosal immunity and inflammation IV. Paneth cell antimicrobial peptides and the biology of the mucosal barrier. Am J Physiol 40:G257-G261, 1999.
4. Cunliffe R. Alpha defensins in the gastrointestinal tract. Mol Immunol 40:463-467, 2003.
5. Agerberth B, Charo J, Werr J, et al. The human antimicrobial and chemotactic peptides LL-37 and α-defensins are expressed by specific lymphocyte and monocyte populations. Blood 96:3086-3093, 2000.
6. Turner J, Cho Y, and Dinh NN. Activities of LL-37, a cathelin associated antimicrobial peptide of human neutrophils. Antimicrob Agents Chemother 42:2206-2214, 1998.
7. Yang D, Chertov O, and Oppenheim JJ. Participation of mammalian defensins and cathelicidins in antimicrobial immunity: Receptors and activities of human defensins and cathelicidin (LL-37). J Leukoc Biol 69:691-697, 2001.
8. Tjabringa G, Aarbiou J, Ninaber D, et al. The antimicrobial peptide ll-37 activates innate immunity at the airway epithelial surface by transactivation of the epidermal growth factor receptor. J Immunol 171:6690-6696, 2003.
9. Schauber J, Svanholm C, Termon S, et al. Expression of the cathelicidin LL-37 is modulated by short chain fatty acids in colonocytes: Relevance of signaling pathways. Gut 52:735-741, 2003.
10. Hase K, Murakami M, Iimura M, M, et al. Expression of LL-37 by human gastric epithelial cells as a potential host defense mechanism against Helicobacter pylori. Gastroenterology 125:1613-1625, 2003.
11. Yang D, Chen Q, Schmidt AP, et al. LL-37, the neutrophil granule-and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells. J Exp Med 192:1069-1074, 2000.
12. Ong P, Ohtake T, Brand T, et al. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med 34:1151-1160, 2002.
13. Yang D, Chertov O, Bykovskaia SN, et al. Beta-defensins: Linking innate and adaptive immunity through dendritic and T cell CCR6. Science 286:525-528, 1999.
14. Wehkamp J, Fellerman K, Herrlinger KR, et al. Human beta-defensin 2 but not beta-defensin1 is expressed preferentially in colonic mucosa of inflammatory bowl disease. Eur J Gastroenterol Hepatol 14:745-752, 2002.
15. Tunzi CR, Harper PA, Bar-Oz B, et al. β-defensin expression in human mammary gland epithelia. Pediatr Res 48:30-35, 2000.
16. Jia H, Starner T, Ackermann M, et al. Abundant human beta-defensin-1 expression in milk and mammary gland epithelium. J Pediatr 138:109, 2001.
17. Armigoda S, Yannaris N, Melton A, and Srivastava M. Identification and quantification of innate immune system mediators in human breast milk. Allergy Asthma Proc 2004. In press.
18. Tsutsumi-Ishii Y, and Nagaoka I. Modulation of human beta defensin-2 transcription in pulmonary epithelial cells by lipopolysaccharide-stimulated mononuclear phagocytes via proinflammatory cytokine production. J Immunol 170:4226-4236, 2003.
19. Niyonsaba F, Iwabuchi K, Hiroshi M, et al. Epithelial cell-derived human beta defensin-2 acts as a chemotaxin for mast cells through a pertussis toxin sensitive and phospholipase c-dependent pathway. Int Immunol 14:421-426, 2002.
20. Fellerman K, Wehkamp J, Herrlinger K, and Stange E. Crohn's disease: A defensin deficiency syndrome. Eur J Gastrenterol Hepatol 15:627-634, 2003.
21. Salzmann NH, Polin E, and Harris MC. Enteric defensin expression in necrotizing enterocolitis. Pediatr Res 44:20-26, 1998.
22. Inoue M, Matsuoka M, Yamaguchi K, et al. Characterization of mRNA expression of IκBα and NF-κB subfamilies in primary adult T cell leukemia cells. Jpn J Cancer Res 89:53-59, 1998.
23. Kanai Y, Usingima S, Dondo Y, et al. DNA methyltransferase expression and DNA methylation of CPG islands and pericentric satellite regions in human colorectal and stomach cancers. Int J Cancer 91:205-212, 2001.
24. Hoover DM, Boulegue DY, Oppenheim JJ, et al. The structure of human macrophage inflammatory protein-3α/CCL20. J Biol Chem 277:37647-37654, 2002.
25. Liao F, Alderson R, Su J, et al. STRL22 is a receptor for the CC chemokine MIP-3α. Biochem Biophys Res Commun 236:212-217, 1997.
26. Diebold SS, Kaisho R, Hemmi H, et al. Innate antiviral responses by means of TLR-7 mediated recognition of single stranded RNA. Science 303:1529-1531, 2004.
27. Srivastava MD, Srivastava A, Brouhard B, et al. Cytokines in human milk. Res Commun Mol Pathol Pharmacol 93:263-287, 1996.
28. Srivastava MD, Lippes J, and Srivastava BIS. Hepatocyte growth factors in human milk and reproductive tract fluids. Am J Reprod Immunol 42:347-354, 1999.
29. Hamosh M. Bioactive factors in human milk. Pediatr Clin North Am 48:69-86, 2001.
30. Lee J, Chuang T, Redecke V, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of toll-like receptor 7. PNAS 100:6646-6651, 2003.
31. Ito T, Amakawa R, Kaisho T, et al. Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets. J Exp Med 195:1507-1512, 2003.
32. Hemmi H, Kaisho T, Takeuchi O, et al. Small anti-viral compounds activate immune cells via the TLR MYD88-dependent signaling pathway. Nat Immunol 3:196-200, 2002.
33. Doxsee CL, Riter T, Riter M, et al. The immune response modifier and toll-like receptor 7 agonist s-27609 selectively induces IL-12 and TNF-α production in CD11c(+)CD11b(+)CD8(-) dendritic cells. J Immunol 171:1156-1163, 2003.
34. Barton G, and Medzhitov R. Toll-like receptor signaling pathways. Science 300:1524-1525, 2003.
35. Frohm M, Agerberth B, Ahangari G, et al. The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders. J Biol Chem 272:15258-15263, 1997.
36. Kim ST, Cha HE, Kim DY, et al. Antimicrobial peptide LL-37 is upregulated in chronic nasal inflammatory disease. Acta Otolaryngol 123:81-85, 2003.
37. Burns K, Clatworthy J, Martin L, et al. Tollip, a new component of the IL1-R1 pathway, links IRAK to the IL-1 receptor. Nat Cell Biol 2:346-351, 2000.
38. Medzhitov R, Preston-Hurlburt P, Kopp E, et al. Myd88 is an adapter protein in the TOLL-IL-1 receptor family signaling pathways. Mol Cell 2:253-258, 1998.
39. Zhang G, and Ghosh S. Regulation of toll-like receptor mediated signaling by Tollip. J Biol Chem 227:59-65, 2002.
40. Fukao T, and Koyasu S. PIK3 and negative regulation of TLR signaling. Trends Immunol 24:358-363, 2003.