Characterization of a tissue factor/factor VIIa-dependent model of thrombosis in hypercholesterolemic rabbits

Journal of Thrombosis and Haemostasis

Volumn 2, Issue 1, 2004, Pages 85-92

  Chi, Liguo ^a   Gibson, G ^a   Peng, Y W ^a   Bousley, R ^a   Brammer, D ^b   Rekhter, M ^a   Chen, J ^a   Leadley, R ^a  

^a PFIZER INC   (United States)

^b Laboratory Animal Surgery   (United States)

Author keywords

Animal model; Atherosclerotic plaque; Thrombosis; Tissue factor

Indexed keywords

3 (5 AMIDINO 2 HYDROXYPHENYL) 1 [5 (2,6 DIMETHYL 1 PIPERIDINYL)PENTYL] 2(1H) QUINOXALINONE; ARGATROBAN; BLOOD CLOTTING FACTOR 10A INHIBITOR; BLOOD CLOTTING FACTOR 7A; BLOOD CLOTTING FACTOR 7A INHIBITOR; MESSENGER RNA; RECOMBINANT BLOOD CLOTTING FACTOR 7A; THROMBOPLASTIN; UNCLASSIFIED DRUG; FIBRINOLYTIC AGENT; LIPID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULANT THERAPY; ARTERY THROMBOSIS; ARTICLE; ATHEROSCLEROTIC PLAQUE; BALLOON CATHETER; BLOOD CLOTTING; CHOLESTEROL DIET; COMPLEX FORMATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; ENDOTHELIUM LESION; FEMORAL ARTERY; HEART MUSCLE ISCHEMIA; HEMOSTASIS; HYPERCHOLESTEROLEMIA; IN VIVO STUDY; NONHUMAN; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; THROMBOGENESIS; ANIMAL; ARTERIOSCLEROSIS; BLOOD; DISEASE MODEL; GENE EXPRESSION; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY; THROMBOSIS;

ANIMALS; ARTERIOSCLEROSIS; DISEASE MODELS, ANIMAL; FACTOR VIIA; FIBRINOLYTIC AGENTS; GENE EXPRESSION; HYPERCHOLESTEROLEMIA; LIPIDS; RABBITS; RNA, MESSENGER; THROMBOPLASTIN; THROMBOSIS;

EID: 4444384417     PISSN: 15387933     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2004.00547.x     Document Type: Article

References (27)

1. Morrissey JH. Tissue factor: an enzyme cofactor and a true receptor. Thromb Haemost 2001; 86: 66-74.
2. Broze GJ. The tissue factor pathway of coagulation. In: Loscalzo J, Schafer A, eds. Thrombosis and Hemorrhage, 2nd edn. Baltimore: Williams & Wilkins, 1998.
3. Wilcox JN, Smith KM, Schwartz SM, Gordon D. Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque. Proc Natl Acad Sci USA 1989; 86: 2839-43.
4. Thiruvikraman SV, Guha A, Roboz J, Taubman MB, Nemerson Y, Fallon JT. In situ localization of tissue factor in human atherosclerotic plaques by binding of digoxigenin-labeled factors VIIa and X. Lab Invest 1996; 75: 451-61.
5. Marmur JD, Thiruvikraman SV, Fyfe BS, Guha A, Sharma SK, Ambrose JA, Fallon JT, Nemerson Y, Taubman MB. Identification of active tissue factor in human coronary atheroma. Circulation 1996; 94 1226-32.
6. Folts JD, Crowell EB, Rowe GG. Platelet aggregation in partially obstructed vessels and its elimination with aspirin. Circulation 1976; 54: 365-70.
7. Romson JL, Haack DW, Lucchesi BR. Electrical induction of coronary artery thrombosis in the ambulatory canine: a model for in vivo evaluation of anti-thrombotic agents. Thromb Res 1980; 17: 841-53.
8. Topol EJ, Ciuffo AA, Pearson TA, Dillman J, Builder S, Grossbard E, Weisfeldt ML, Bulkley BH. Thrombolysis with recombinant tissue plasminogen activator in atherosclerotic thrombotic occlusion. J Am Coll Cardiol 1985; 5: 85-91.
9. Abela GS, Picon PD, Friedl SE, Gebara OC, Miyamoto A, Federman M, Tofler G, Muller JE. Triggering of plaque disruption and arterial thrombosis in an atherosclerotic rabbit model. Circulation 1995; 91: 776-84.
10. Asada Y, Hara S, Tsuneyoshi A, Hatakeyama K, Kisanuki A, Marutsuka K, Sato Y, Kamikubo Y, Sumiyoshi A. Fibrin-rich and platelet-rich thrombus formation on neointima: recombinant tissue factor pathway inhibitor prevents fibrin formation and neointimal development following repeated balloon injury of rabbit aorta. Thromb Haemost 1998; 80: 506-11.
11. Meade TW, Mellows S, Brozovic M, Miller SG, Chakrabarti RR, North WRS, Haines AP, Stirling Y, Imeson JD, Thompson SG. Haemostatic function and ischaemic heart disease. Principal results of the Northwick Park Heart Study. Lancet 1986; 2: 533-7.
12. Holm J, Todt T, Berntorp E, Erhardt L. Failure of thrombolytic therapy in patients with myocardial infarction is associated with high plasma levels of factor VII antigen. Thromb Haemost 1998; 79: 928-31.
13. Kurz KD, Main BW, Sandusky GE. Rat model of arterial thrombosis induced by ferric chloride. Thromb Res 1990; 60: 269-80.
14. Sato M, Ohshima N. A new experimental model for inducing platelet thrombus in the microvasculature: basic study on its feasibility. Blood Vessel 1984; 15: 36-44.
15. Kato K, Elsayed YA, Namoto M, Nakagawa K, Sueishi K. Enhanced expression of tissue factor activity in the atherosclerotic aortas of cholesterol-fed rabbits. Thromb Res 1996; 82: 335-47.
16. Marmur JD, Rossikhina M, Guha A, Fyfe B, Friedrich V, Mendlowitz M, Nemerson Y, Taubman MB. Tissue factor is rapidly induced in arterial smooth muscle after balloon injury. J Clin Invest 1993; 91: 2253-9.
17. Johnstone MT, Botnar RM, Perez AS, Stewart R, Quist WC, Hamilton JA, Manning WJ. In vivo magnetic resonance imaging of experimental thrombosis in a rabbit model. Arterioscler Thromb Vasc Biol 2001; 21: 1556-60.
18. Lyle EM, Fujita T, Conner MW, Connolly TM, Vlasuk GP, Lynch JL. Effect of inhibitors of factor Xa or platelet adhesion, heparin, and aspirin on platelet deposition in an atherosclerotic rabbit model of angioplasty injury. J Pharmacol Toxicol Meth 1995; 33: 53-61.
19. Sorensen BB, Persson E, Freskgard P, Kjalke M, Ezban M, Williams T, Rao VM. Incorporation of an active site inhibitor in factor VIIa alters the affinity for tissue factor. J Biol Chem 1997; 272: 11863-8.
20. Meade TW, North WRS, Chakrabarti RR, Stirling Y, Haines AP, Thompson SG. Haemostatic function and cardiovascular death: early results of a prospective study. Lancet 1980; 1: 1050-4.
21. Mitropoulos KA, Esnouf MP, Meade TW. Increased factor VII coagulant activity in the rabbit following diet-induced hypercholesterolaemia. Evidence for increased conversion of VII to VIIa and higher flux within the coagulation pathway. Atherosclerosis 1987; 63: 43-52.
22. Mari D, Vigotti G, Vergani C, Mannucci PM. Hemostatic functions in hypoalpha and hyperbetalipoproteinemias. Thromb Haemost 1983; 50: 624.
23. Simpson HCR, Mann JI, Meade TW, Chakrabarti RR, Stirling Y, Woolf L. Hypertriglyceridaemia and hypercoagulability. Lancet 1983; I: 786.
24. Bladbjerg EM, Marckmann P, Sandstrom B, Jespersen J. Non-fasting factor VII coagulant activity (FVII:C) increased by high-fat diet. Thromb Haemost 1994; 71: 755-8.
25. Saigo M, Abe S, Ogawa M, Biro S, Minagoe S, Maruyama I, Toda H, Kiyonaga K, Atsuchi Y, Tahara M, Mawatari K, Tei C. Plasma level of triglyceride-rich lipoprotein remnants is closely associated with the activation of coagulation factor VII in patients with myocardial infarction. Thromb Res 2000; 100: 9-17.
26. Hertz R, Magenheim J, Berman I, Bar-Tana J. Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor-4a. Nature 1998; 392: 512-6.
27. Hung HL, Pollak ES, Kudaravalli RD, Arruda V, Chu K, High KA. Regulation of human coagulation factor X gene expression by GATA-4 and the Sp family of transcription factors. Blood 2001; 97: 946-51.