Atomic resolution structures and solution behavior of enzyme-substrate complexes of Enterobacter cloacae PB2 pentaerythritol tetranitrate reductase: Multiple conformational states and implications for the mechanism of nitroaromatic explosive degradation

Journal of Biological Chemistry

Volumn 279, Issue 29, 2004, Pages 30563-30572

  Khan, Huma ^a   Barna, Terez ^a   Harris, Richard J ^a   Bruce, Neil C ^b   Barsukov, Igor ^a   Munro, Andrew W ^a   Moody, Peter C E ^a   Scrutton, Nigel S ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF YORK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACIDS; CARRIER CONCENTRATION; MUTAGENESIS; SUBSTRATES;

ATOMIC RESOLUTION STRUCTURES; PICRIC ACID;

ENZYMES;

AROMATIC NITRO COMPOUND; EXPLOSIVE; HYDRIDE MEISENHEIMER COMPLEX; MUTANT PROTEIN; NITRO DERIVATIVE; PENTAERYTHRITOL TETRANITRATE REDUCTASE; PENTAERYTHRITYL TETRANITRATE; PICRIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRYPTOPHAN; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; COVALENT BOND; CRYSTAL STRUCTURE; ENTEROBACTER CLOACAE; ENTEROBACTER CLOACAE PB2; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME DEGRADATION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; REDUCTION;

2,4-DINITROPHENOL; AMINO ACID SEQUENCE; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENTEROBACTER CLOACAE; KINETICS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; OXIDOREDUCTASES; PICRATES; PROGESTERONE; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; TIME FACTORS; TRYPTOPHAN;

ENTEROBACTER; ENTEROBACTER CLOACAE;

EID: 3142695539     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M403541200     Document Type: Article

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