Reaction of morphinone reductase with 2-cyclohexen-1-one and 1-nitrocyclohexene: Proton donation, ligand binding, and the role of residues histidine 186 and asparagine 189

Journal of Biological Chemistry

Volumn 280, Issue 11, 2005, Pages 10695-10709

  Messiha, Hanan Latif ^a   Munro, Andrew W ^a   Bruce, Neil C ^b   Barsukov, Igor ^a   Scrutton, Nigel S ^a,b  

^a UNIVERSITY OF YORK   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION; PROTONS; REACTION KINETICS; REDUCTION;

ALANINES; CARBONYL COMPOUNDS; MORPHINONE REDUCTASE (MR); OLD YELLOW ENZYME (OYE1);

CATALYSIS;

1 NITROCYCLOHEXENONE; 2 CYCLOHEXENONE; ALANINE; ASPARAGINE; CARBONYL DERIVATIVE; HISTIDINE; MORPHINONE OXIDOREDUCTASE; OXIDOREDUCTASE; QUERCETIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; LIGAND BINDING; MUTAGENESIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION REDUCTION REACTION; POTENTIOMETRY; PRIORITY JOURNAL; PROTON TRANSPORT;

ALANINE; AMINO ACID SEQUENCE; ASPARAGINE; BACTERIAL PROTEINS; BINDING SITES; CARBON; CATALYSIS; CYCLOHEXANES; CYCLOHEXANONES; CYCLOHEXENES; ESCHERICHIA COLI; HISTIDINE; HYDROGEN; HYDROGEN-ION CONCENTRATION; KINETICS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS; OXIDATION-REDUCTION; OXIDATIVE STRESS; OXIDOREDUCTASES; OXYGEN; PROTEIN BINDING; PROTEIN CONFORMATION; PROTONS; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROPHOTOMETRY; SUBSTRATE SPECIFICITY; TIME FACTORS; ULTRAVIOLET RAYS;

EID: 15444372631     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M410595200     Document Type: Article

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