Effects of long-term microgravity exposure on cancellous and cortical weight-bearing bones of cosmonauts

Lancet

Volumn 355, Issue 9215, 2000, Pages 1607-1611

  Vico, Laurence ^a   Collet, Philippe ^a   Guignandon, Alain ^a   Lafage Proust, Marie Hélène ^a   Thomas, Thierry ^a   Rehailia, Mohamed ^b   Alexandre, Christian ^a  

^a INSERM   (France)

^b UNIVERSITÉ JEAN MONNET   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AEROSPACE MEDICINE; ARTICLE; BONE ATROPHY; BONE DENSITY; BONE MINERAL; CANCELLOUS BONE; CONTROLLED STUDY; CORTICAL BONE; COSMONAUT; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MICROGRAVITY; NORMAL HUMAN; OSTEOPOROSIS; PRIORITY JOURNAL; SPACE FLIGHT; TIBIA; TRAINING;

EID: 0034612094     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(00)02217-0     Document Type: Article

References (22)

1. Vogel J.M., Whittle M.W., Smith M.C. Jr.et al. Bone mineral measurement-experiment M078. Biomedical Results from Skylab. 1977;183-190 NASA, Washington, DC.
2. Stupakov G.P., Kazeykin V.S., Kozlovskiy A.P., Korolev V.V. Evaluation of changes in human axial skeletal bone structure during long-term spaceflights. Space Biol Med. 18:1984;42-47.
3. Oganov V.S., Grigoriev A.I., Voronin L.I.et al. Bone mineral density in cosmonauts after 4·5-6 month long flights aboard orbital station MIR. Aerospace Environ Med. 26:1992;20-24.
4. LeBlanc A., Shackelford L., Schneider V. Future human bone research in space. Bone. 22(suppl):1998;113-116.
5. Oganov V.S., Cann C., Rakmanov A.S., Ternevoy S.K. A computer tomographic investigation on the musculoskeletal system of the spine in human after long-term space flight. Kosmichesk Biol I Aviakosmichesk Med. 24:1990;20-21.
6. LeBlanc A.D., Schneider V., Shackelford L.L.et al. Bone mineral and lean tissue loss after long duration spaceflight. J Bone Miner Res. 11(suppl):1996;323. (abstr).
7. Schneider V., Oganov V., Leblanc A.et al. Spaceflight bone loss and change in fat and lean body mass. J Bone Miner Res. 7(suppl 1):1992;122. (abstr).
8. Collet P., Uebelhart D., Vico L.et al. Effects of 1 month and 6 month spaceflight on bone mass and biochemistry on two humans. Bone. 20:1997;547-551.
9. Muller A., Rüegsegger P., Seitz P. Optimal CT settings for bone evaluations. Phys Med Biol. 5:1985;401-409.
10. Rüegsegger P., Durand E., Dambacher M.D. Localisation of regional forearm bone loss from high resolution computed tomographic images. Osteoporosis Int. 1:1991;76-80.
11. Mustalahti K., Collin P., Sievänen H., Salmi J., Mäki M. Osteopenia in patients with clinically silent coeliac disease warrants screening. Lancet. 354:1999;744.
12. Leblanc A.D., Schneider V.S., Evans H.J., Engelbretson D.A., Krebs J.M. Bone mineral density and recovery after 17 weeks of bed rest. J Bone Miner Res. 5:1990;843-850.
13. White R.J., Blomqvist C.G. Central venous pressure and cardiac function during spaceflight. J Appl Physiol. 85:1998;738-746.
14. Minaire P., Meunier P.J., Edouard C., Bernard J., Courpron P., Bourret J. Quantitative histological data on disuse osteoporosis. Calcif Tissue Int. 17:1974;57-73.
15. Jouanny P., Guillemin F., Kuntz C., Jeandel C., Pourel J. Environmental and genetic factors affecting bone mass. similarity of bone density among members of healthy families Arthritis Rheum. 38:1995;61-67.
16. Arden N.K., Spector T.D. Genetic influences on muscle strength, lean body mass, and bone mineral density. a twin study J Bone Miner Res. 12:1997;2076-2081.
17. Samara K., Kelly P.J., Chiano M.N., Spector T.D., Campbell L.V. Genetic and environmental influences on total-body and central abdominal fat. the effect of physical activity in female twins Ann Intern Med. 130:1999;873-882.
18. Zerwekh J.E., Rumi L.A., Gottschalk F., Pak C.Y.C. The effects of twelve weeks of bed rest on bone histology, biochemical markers of bone turnover, and calcium homeostasis in eleven normal subjects. J Bone Miner Res. 13:1998;1594-1601.
19. Lafage-Proust M.H., Collet P., Dubost J.M., Laroche N., Alexandre C., Vico L. Space-related bone mineral redistribution and lack of bone mass recovery after reambulation in young rats. Am J Physiol. 274:1998;R324-R334.
20. Zerath E., Novikov V., Leblanc A., Bakulin A., Oganov V., Grynpas M. Effects of spaceflights on bone mineralisation in the rhesus monkey. J Appl Physiol. 81:1996;194-200.
21. Caillot-Augusseau A., Lafage-Proust M.H., Soler C.et al. Bone formation and resorption biological markers in cosmonauts during and after a 180-day space flight (Euromir 95). Clin Chem. 44:1998;578-585.
22. Smith S.M., Nillen J.L., Leblanc A.et al. Collagen cross-link excretion during space flight and bed rest. J Clin Endocrinol Metab. 83:1998;3584-3591.