RGS14 is a microtubule-associated protein

Cell Cycle

Volumn 4, Issue 7, 2005, Pages 953-960

  Martin McCaffrey, Luke ^a,b   Willard, Francis S ^c   Pajak, Agnieszka ^a,b   Dagnino, Lina ^a,b   Siderovski, David P ^c   D'Souza, Sudhir J A ^a,b  

^a Siebens Drake Research Institute   (Canada)

^b WESTERN UNIVERSITY   (Canada)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Cell division; Heterotrimeric G protein signaling; Microtubule dynamis; Microtubule associated protein (MAP); Mitosis; Regulator of G protein signaling; RGS14; Tubulin

Indexed keywords

CELL EXTRACT; MICROTUBULE ASSOCIATED PROTEIN; PACLITAXEL; RGS PROTEIN; TUBULIN;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL DIVISION; CONTROLLED STUDY; DEPOLYMERIZATION; EMBRYO; HELA CELL; HUMAN; HUMAN CELL; MICROTUBULE; MITOSIS; MITOSIS SPINDLE; NONHUMAN; POLYMERIZATION;

DYNAMIS; MAMMALIA; SUIDAE;

EID: 25444483368     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.4.7.1787     Document Type: Article

References (64)

1. Maiato H, Sampaio P, Sunkel CE. Microtubule-associated proteins and their essential roles during mitosis. Int Rev Cytol 2004; 241:53-153.
2. Holmfeldt P, Larsson N, Segerman B, Howell B, Morabito J, Cassimeris L, Gullberg M. The catastrophe-promoting activity of ectopic Op18/stathmin is required for disruption of mitotic spindles but not interphase microtubules. Mol Biol Cell 2001; 12:73-83.
3. Mollinedo F, Gajate C. Microtubules, microtubule-interfering agents and apoptosis. Apoptosis 2003; 8:413-50.
4. Gilman AG. G proteins: Transducers of receptor-gene rated signals. Annu Rev Biochem 1987; 56:615-49.
5. McCudden CR, Hains MD, Kimple RJ, Siderovski DP, Willard FS. G-protein signaling: Back to the future. Cell Mol Life Sci 2005; 62:551-77.
6. Tall GG, Krumins AM, Gilman AG. Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor. J Biol Chem 2003; 278:8356-62.
7. Miller KG, Emerson MD, McManus JR, Rand JB. RIC-8 (Synembryn): A novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system. Neuron 2000; 27:289-99.
8. Miller KG, Rand JB. A role for RIC-8 (Synembryn) and GOA-1 (G(o)alpha) in regulating a subset of centrosome movements during early embryogenesis in Caenorhabditis elegans. Genetics 2000; 156:1649-60.
9. Willard FS, Kimple RJ, Siderovski DP. Return of the GDI: The GoLoco motif in cell division. Annu Rev Biochem 2004; 73:925-51.
10. Sierra DA, Gilbert DJ, Householder D, Grishin NV, Yu K, Ukidwe P, Barker SA, He W, Wensel TG, Otero G, Brown G, Copeland NG, Jenkins NA, Wilkie TM. Evolution of the regulators of G-protein signaling multigene family in mouse and human. Genomics 2002; 79:177-85.
11. Neubig RR, Siderovski DP. Regulators of G-protein signalling as new central nervous system drug targets. Nat Rev Drug Discov 2002; 1:187-97.
12. Schweisguth F. Cell polarity: Fixing cell polarity with Pins. Curr Biol 2000; 10(7):R265-7.
13. Hampoelz B, Knoblich JA. Heterotrimeric G proteins: New tricks for an old dog. Cell 2004; 119:453-6.
14. Parmentier ML, Woods D, Greig S, Phan PG, Radovic A, Bryant P, O'Kane CJ. Rapsynoid/partner of inscuteable controls asymmetric division of larval neuroblasts in Drosophila. J Neurosci 2000; 20:RC84.
15. Yu F, Morin X, Cai Y, Yang X, Chia W. Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localization. Cell 2000; 100:399-409.
16. Schaefer M, Petronczki M, Dorner D, Forte M, Knoblich JA. Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous system. Cell 2001; 107:183-94.
17. Gotta M, Ahringer J. Distinct roles for Galpha and Gbetagamma in regulating spindle position and orientation in Caenorhabditis elegans embryos. Nat Cell Biol 2001; 3:297-300.
18. Colombo K, Grill SW, Kimple RJ, Willard FS, Siderovski DP, Gonczy P. Translation of polarity cues into asymmetric spindle positioning in Caenorhabditis elegans embryos. Science 2003; 300:1957-61.
19. Afshar K, Willard FS, Colombo K, Johnston CA, McCudden CR, Siderovski DP, Gonczy P. RIC-8 is required for GPR-1/2-dependent Galpha function during asymmetric division of C. elegans embryos. Cell 2004; 119:219-30.
20. Hess HA, Roper JC, Grill SW, Koelle MR. RGS-7 completes a receptor-in dependent heterotrimeric G protein cycle to asymmetrically regulate mitotic spindle positioning in C. elegans. Cell 2004; 119:209-18.
21. Zernicka-Goetz M. Patterning of the embryo: The first spatial decisions in the life of a mouse. Development 2002; 129:815-29.
22. Cayouette M, Raff M. Asymmetric segregation of Numb: A mechanism for neural specification from Drosophila to mammals. Nat Neurosci 2002; 5:1265-9.
23. Cayouette M, Whitmore AV, Jeffery G, Raff M. Asymmetric segregation of Numb in retinal development and the influence of the pigmented epithelium. J Neurosci 2001; 21:5643-51.
24. Shen Q, Zhong W, Jan YN, Temple S. Asymmetric Numb distribution is critical for asymmetric cell division of mouse cerebral cortical stem cells and neuroblasts. Development 2002; 129:4843-53.
25. Mochizuki N, Cho G, Wen B, Insel PA. Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction witk G alpha i2. Gene 1996; 181:39-43.
26. Takesono A, Cismowski MJ, Ribas C, Bernard M, Chung P, Hazard IIIrd S, Duzic E, Lanier SM. Receptor-independent activators of heterotrimeric G-protein signaling pathways. J Biol Chem 1999; 274:33202-5.
27. Yu F, Morin X, Kaushik R, Bahri S, Yang X, Chia W. A mouse homologue of Drosophila pins can asymmetrically localize and substitute for pins function in Drosophila neuroblasts. J Cell Sci 2003; 116:887-96.
28. Du Q, Stukenberg PT, Macara IG. A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization. Nat Cell Biol 2001; 3:1069-75.
29. Kaushik R, Yu F, Chia W, Yang X, Bahri S. Subcellular localization of LGN during mitosis: Evidence for its cortical localization in mitotic cell culture systems and its requirement for normal cell cycle progression. Mol Biol Cell 2003; 14:3144-55.
30. Du Q, Macara IG. Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins. Cell 2004; 119:503-16.
31. Roychowdhury S, Rasenick MM. G protein beta1gamma2 subunits promote microtubule assembly. J Biol Chem 1997; 272:31576-81.
32. Roychowdhury S, Panda D, Wilson L, Rasenick MM. G protein alpha subunits activate tubulin GTPase and modulate microtubule polymerization dynamics. J Biol Chem 1999; 274:13485-90.
33. Snow BE, Antonio L, Suggs S, Gutstein HB, Siderovski DP. Molecular cloning and expression analysis of rat Rgs12 and Rgs14. Biochem Biophys Res Commun 1997; 233:770-7.
34. Cho H, Kozasa T, Takekoshi K, De Gunzburg J, Kehrl JH. RGS14, a GTPase-activating protein for Gialpha, attenuates Gialpha- and G13alpha-mediated signaling pathways. Mol Pharmacol 2000; 58:569-76.
35. Kimple RJ, De Vries L, Tronchere H, Behe CI, Morris RA, Gist Farquhar M, Siderovski DP. RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity. J Biol Chem 2001; 276:29275-81.
36. Traver S, Splingard A, Gaudriault G, De Gunzburg J. The RGS (regulator of G-protein signalling) and GoLoco domains of RGS14 cooperate to regulate Gi-mediated signalling. Biochem J 2004; 379:627-32.
37. Martin-McCaffrey L, Willard FS, Oliveira-dos-Santos AJ, Natale DR, Snow BE, Kimple RJ, Pajak A, Watson AJ, Dagnino L, Penninger JM, Siderovski DP, D'Souza SJ. RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote. Dev Cell 2004; 7:763-9.
38. Cho H, Kim DU, Kehrl JH. RGS14 Is a Centrosomal and nuclear cytoplasmic shuttling protein that traffics to promyelocytic leukemia nuclear bodies following heat shock. J Biol Chem 2005; 280:805-14.
39. Waterman-Storer CM. Microtubule/organelle motility assays. In: Bonifacino JS, Dasso M, Harford JB, Lippincott-Schwartz J, Yamada KM, eds. Current Protocols in Cell Biology. New York: John Wiley, 2003.
40. Martin-McCaffrey L, Willard FS, Pajak A, Dagnino L, Siderovski DP, D'Souza SJ. Analysis of interactions between regulator of G-protein signaling-14 and microtubules. Methods Enzymol 2004; 390:240-58.
41. Goode BL, Feinstein SC. Identification of a novel microtubule binding and assembly domain in the developmentally regulated inter-repeat region of tau. J Cell Biol 1994; 124:769-782.
42. Sarma T, Voyno-Yasenetskaya T, Hope TJ, Rasenick MM. Heterotrimeric G-proteins associate with microtubules during differentiation in PC12 pheochromocytoma cells. Faseb J 2003; 17:848-59.
43. Wu HC, Huang PH, Lin CT. G protein beta subunit is closely associated with microtubules. J Cell Biochem 1998; 70:553-62.
44. Gaskin F, Cantor CR, Shelanski ML. Turbidimetric studies of the in vitro assembly and disassembly of porcine neurotubules. J Mol Biol 1974; 89:737-55.
45. Gaglio T, Dionne MA, Compton DA. Mitotic spindle poles are organized by structural and motor proteins in addition to centrosomes. J Cell Biol 1997; 138:1055-66.
46. Gaglio T, Saredi A, Compton DA. NuMA is required for the organization of microtubules into aster-like mitotic arrays. J Cell Biol 1995; 131:693-708.
47. Gregson HC, Schmiesing JA, Kim JS, Kobayashi T, Zhou S, Yokomori K. A potential role for human cohesin in mitotic spindle aster assembly. J Biol Chem 2001; 276:47575-82.
48. Huang SC, Jagadeeswaran R, Liu ES, Benz Jr EJ. Protein 4.1R, a microtubule-associated protein involved in microtubule aster assembly in mammalian mitotic extract. J Biol Chem 2004; 15:2978-91.
49. Vespa A, Darmon AJ, Turner CE, D'Souza SJ, Dagnino L. Ca2+-dependent localization of integrin-linked kinase to cell junctions in differentiating keratinocytes. J Biol Chem 2003; 278:11528-35.
50. Du Q, Taylor L, Compton DA, Macara IG. LGN blocks the ability of NuMA to bind and stabilize microtubules. A Mechanism for Mitotic Spindle Assembly Regulation. Curr Biol 2002; 12:1928-33.
51. Gotta M, Dong Y, Peterson YK, Lanier SM, Ahringer J. Asymmetrically distributed C. elegans homologs of AGS3/PINS control spindle position in the early embryo. Curr Biol 2003; 13:1029-37.
52. Srinivasan DG, Fisk RM, Xu H, van den Heuvel S. A complex of LIN-5 and GPR proteins regulates G protein signaling and spindle function in C elegans. Genes Dev 2003; 17:1225-39.
53. Couwenbergs C, Spilker AC, Gotta M. Control of embryonic spindle positioning and Galpha activity by C. elegans RIC-S. Curr Biol 2004; 14:1871-6.
54. Nixon AB, Grenningloh G, Casey PJ. The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly. J Biol Chem 2002; 277:18127-18133.
55. Nixon AB, Casey PJ. Analysis of the regulation of microtubule dynamics by interaction of RGSZ1 (RGS20) with the neuronal stathmin, SCG10. Methods Enzymol 2004; 390:53-64.
56. Liu Z, Chatterjee TK, Fisher RA. RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6. J Biol Chem 2002; 277:37832-9.
57. Chang WY, Bryce DM, D'Souza SJ, Dagnino L. The DP-1 transcription factor is required for keratinocyte growth and epidermal stratification. J Biol Chem 2004; 279:51343-53.
58. Robinson JM, Vandre DD. Antigen retrieval in cells and tissues: Enhancement with sodium dodecyl sulfate. Histochem Cell Biol 2001; 116:119-30.
59. Van Noorden S. Advances in immunocytochemistry. Folia Histochem Cytobiol 2002; 40:121-4.
60. Kimple RJ, Willard FS, Hains MD, Jones MB, Nweke GK, Siderovski DP. Guanine nucleotide dissociation inhibitor activity of the triple GoLoco motif protein G18: Alanine-to-aspartate mutation restores function to an inactive second GoLoco motif. Biochem J 2004; 378:801-8.
61. Willard FS, Siderovski DP. Purification and in vitro functional analysis of the Arabidopsis thaliana regulator of G-protein signaling-1. Methods Enzymol 2004; 389:320-38.
62. Willard FS, Kimple AJ, Johnston CA, Siderovski DP. A direct fluorescence-based assay for RGS domain GTPase accelerating activity. Anal Biochem 2005; 340:341-51.
63. Kimple RJ, Willard FS, Siderovski DP. Purification and in vitro functional analyses of RGS12 and RGS14 GoLoco motif peptides. Methods Enzymol 2004; 390:416-36.
64. D'Souza SJ, Pajak A, Balazsi K, Dagnino L. Ca2+ and BMP-6 signaling regulate E2F during epidermal keratinocyte differentiation. J Biol Chem 2001; 276:23531-8.