Cardioprotective efficacy of zoniporide, a potent and selective inhibitor of Na +/H + exchanger isoform 1, in an experimental model of cardiopulmonary bypass

British Journal of Pharmacology

Volumn 142, Issue 1, 2004, Pages 57-66

  Clements Jewery, Hugh ^a   Sutherland, Fiona J ^a   Allen, Mary C ^b   Tracey, W Ross ^b   Avkiran, Metin ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Cardioplegia; Cardiopulmonary bypass; Ischaemia; Na + H + exchanger; Zoniporide

Indexed keywords

MYELOPEROXIDASE; SODIUM PROTON EXCHANGE PROTEIN 1; ZONIPORIDE;

ACIDIFICATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOPLEGIA; CARDIOPULMONARY BYPASS; CELL ISOLATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; ENZYME ACTIVITY; HEART ARREST; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; HYPOTHERMIA; IC 50; INHIBITION KINETICS; ISOLATED HEART; MALE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTON TRANSPORT; RAT; STATISTICAL SIGNIFICANCE;

ANIMALS; CARDIOPLEGIC SOLUTIONS; CARDIOPULMONARY BYPASS; CARDIOTONIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; GUANIDINES; HEART ARREST, INDUCED; MALE; MYOCYTES, CARDIAC; PROTEIN ISOFORMS; PYRAZOLES; RATS; RATS, WISTAR; SODIUM-HYDROGEN ANTIPORTER;

EID: 2542632719     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705749     Document Type: Article

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