Blood cardioplegia supplementation with the sodium-hydrogen ion exchange inhibitor cariporide to attenuate infarct size and coronary artery endothelial dysfunction after severe regional ischemia in a canine model

Journal of Thoracic and Cardiovascular Surgery

Volumn 125, Issue 1, 2003, Pages 155-164

  Muraki, Satoshi ^a   Morris, Cullen D ^a   Budde, Jason M ^a   Zhao, Zhi Qing ^a   Guyton, Robert A ^a   Vinten Johansen, Jakob ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Carlyle Fraser Heart Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; CARIPORIDE; MYELOPEROXIDASE; NITROPRUSSIDE SODIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA CLAMPING; ARTICLE; CALCIUM CELL LEVEL; CARDIOPLEGIA; CARDIOPULMONARY BYPASS; CONTROLLED STUDY; DOG; ENZYME ACTIVITY; FEMALE; HEART EDEMA; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; NEUTROPHIL; NONHUMAN; PERIOPERATIVE PERIOD; PRIORITY JOURNAL; REPERFUSION INJURY; SODIUM CALCIUM EXCHANGE;

EID: 0037245586     PISSN: 00225223     EISSN: None     Source Type: Journal    
DOI: 10.1067/mtc.2003.65     Document Type: Article

References (39)

1. Karmazyn M, Moffat MP. Role of Na+/H+ exchange in cardiac physiology and pathophysiology: mediation of myocardial reperfusion injury by the pH paradox [review]. Cardiovasc Res. 1993;27:915-24.
2. Frölich O, Karmazyn M. The Na-H exchanger revisited: an update on Na-H exchange regulation and the role of the exchanger in hypertension and cardiac function in health and disease. Cardiovasc Res. 1997;36:138-48.
3. Avkiran M. Rational basis for use of sodium-hydrogen exchange inhibitors in myocardial ischemia. Am J Cardiol. 1999;83:10G-7G.
4. Pike MM, Luo CS, Clark MD, Kirk KA, Kitakaze M, Madden MC, et al. NMR measurements of Na+ and cellular energy in ischemic rat heart: role of Na+-H+ exchange. Am J Physiol. 1993;265(6 Pt 2):H2017-26.
5. Xiao XH, Allen DG. Activity of the Na+/H+ exchanger is critical to reperfusion damage and preconditioning in the isolated rat heart. Cardiovasc Res. 2000;48:244-53.
6. Opie LH. Postischemic stunning - the case for calcium as the ultimate culprit [review]. Cardiovasc Drugs Ther. 1991;5:895-9.
7. 2+ activation of contraction as a consequence of reperfusion-induced cellular calcium overload in ferret hearts. J Clin Invest. 1987;79:950-61.
8. Karmazyn M. Sodium-hydrogen exchange inhibition - a superior cardioprotective strategy [editorial]. J Thorac Cardiovasc Surg. 1996; 112:776-7.
9. Scholz W, Albus U, Counillon L, Gogelein H, Lang HJ, Linz W, et al. Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion. Cardiovasc Res. 1995;29:260-8.
10. Myers ML. Protection of the myocardium with sodium-hydrogen exchange inhibitors: a cardiac surgical perspective. J Thromb Thrombolysis. 1999;8:53-60.
11. Knight DR, Smith AL, Flynn DM, MacAndrew JT, Ellery SS, Kong JX, et al. A novel sodium-hydrogen exchanger isoform-1 inhibitor, zoniporide, reduces ischemic myocardial injury in vitro and in vivo. J Pharmacol Exp Ther. 2001;297:254-9.
12. + exchanger confers greater cardioprotection against 90 minutes of myocardial ischemia than ischemic preconditioning in dogs. Circulation. 1999;100:2519-26.
13. McDonough KH, Giaimo ME, Miller HI. Effects of endotoxin on the guinea pig heart response to ischemia reperfusion injury. Shock. 1995;4:139-42.
14. Gumina RJ, Mizumura T, Beier N, Schelling P, Schultz JJ, Gross GJ. A new sodium/hydrogen exchange inhibitor, EMD 85131, limits infarct size in dogs when administered. J Pharmacol Exp Ther. 1998; 286:175-83.
15. + exchange inhibitor reduces infarct size in pigs. Cardiovasc Res. 1995;30:945-51.
16. Jordan JE, Zhao ZQ, Vinten-Johansen J. The role of neutrophils in myocardial ischemia-reperfusion injury. Cardiovasc Res. 1999;43: 860-78.
17. Boyle EM, Pohlman TH, Johnson MC, Verrier ED. Endothelial cell injury in cardiovascular surgery: the systemic inflammatory response. Ann Thorac Surg. 1997;63:277-84.
18. Choy IO, Schepkin VD, Budinger TF, Obayashi DY, Young JN, DeCampli WM. Effects of specific sodium/hydrogen exchange inhibitor during cardioplegic arrest. Ann Thorac Surg. 1997;64:94-9.
19. + exchange inhibitor HOE 694. Ann Thorac Surg. 1996;61:1400-6.
20. Theroux P, Chaitman BR, Danchin D, Erhardt L, Meinertz T, Schroeder JS, et al. Inhibition of the sodium-hydrogen exchanger with cariporide to prevent myocardial infarction in high-risk ischemic situations. Circulation. 2000;102:3032-8.
21. Thourani VH, Ronson RS, Van Wylen DG, Shearer ST, Katzmark SL, Zhao ZQ, et al. Adenosine-supplemented blood cardioplegia attenuates postischemic dysfunction after severe regional ischemia. Circulation. 1999;100(19 Suppl):II376-83.
22. Nakanishi K, Vinten-Johansen J, Lefer DJ, Zhao Z, Fowler WC, McGee DS, et al. Intracoronary l-arginine during reperfusion improves endothelial function and reduces infarct size. Am J Physiol. 1992;263:H1650-8.
23. Zhao ZQ, Todd JC, Sato H, Ma XL, Vinten-Johansen J. Adenosine inhibition of neutrophil damage during reperfusion does not involve K(ATP)-channel activation. Am J Physiol. 1997;273(4 Pt 2):H1677-87.
24. Muraki S, Morris CD, Budde JM, Velez DA, Zhao ZQ, Guyton RA, et al. Experimental off-pump coronary artery revascularization with adenosine enhanced reperfusion. J Thorac Cardiovasc Surg. 2001;121:570-9.
25. + exchange immediately during reperfusion. Am J Physiol. 1997;273(5 Pt 2):H2232-9.
26. Garcia-Dorado D, Gonzalez MA, Barrabes JA, Ruiz-Meana M, Solares J, Lidon RM, et al. Prevention of ischemic rigor contracture during coronary occlusion by inhibition of Na+-H+ exchange. Cardiovasc Res. 1997;35:80-9.
27. Klein HH, Pich S, Bohle RM, Wollenweber J, Nebendahl K. Myocardial protection by Na+-H+ exchange inhibition in ischemic, reperfused porcine hearts. Circulation. 1995;92:912-7.
28. Yasutake M, lbuki C, Hearse DJ, Avkiran M. Na+/H+ exchange and reperfusion arrhythmias: protection by intracoronary infusion of a novel inhibitor. Am J Physiol. 1994;267(6 Pt 2):H2430-40.
29. Humphreys RA, Haist JV, Chakrabarti S, Feng Q, Arnold JM. Karmazyn M. Orally administered NHEl inhibitor cariporide reduces acute responses to coronary occlusion and reperfusion. Am J Physiol. 1999;276(2 Pt 2):H749-57.
30. Chakrabarti S, Hoque AN, Karmazyn M. A rapid ischemia-induced apoptosis in isolated rat hearts and its attenuation by the sodium-hydrogen exchange inhibitor HOE 642 (cariporide). J Mol Cell Cardiol. 1997;29:3169-74.
31. + exchange to ischemia-reperfusion injury after hypothermic cardioplegic arrest. Ann Thorac Surg. 1997;63:1107-12.
32. 2+ overload in isolated perfused rabbit heart. Circulation. 1994;89:2787-98.
33. + exchange inhibitor cariporide attenuates cell injury predominantly during ischemia and not at onset of reperfusion in porcine hearts with low residual blood flow. Circulation. 2000;102:1977-82.
34. Martin J, Sarai K, Yoshitake M, Haberstroh J, Takahashi N, Lutter G, et al. Orthotopic transplantation of pig hearts harvested after 30 min of normothermic ischemia: controlled reperfusion with blood cardioplegia containing the Na+-H+-exchange inhibitor HOE 642. Eur J Cardiothorac Surg. 1998;14:607-14.
35. Gumina RJ, Auchampach JA, Wang R, Buerger E, Eickmeier C, Moore J, et al. Na+/H+ exchange inhibition-induced cardioprotection in dogs: effects on neutrophils versus cardiomyocytes. Am J Physiol Heart Circ Physiol. 2000;279:H1563-70.
36. Fliegel L, Dyck JR. Molecular biology of the cardiac sodium/hydrogen exchanger. Cardiovasc Res. 1995;29:155-9.
37. Grace AA, Kirschenlohr HL, Metcalfe JC, Smith GA, Weissberg PL, Cragoe EJ, et al. Regulation of intracellular pH in the perfused heart by external HCO3- and Na(+)-H+ exchange. Am J Physiol. 1993; 265(1 Pt 2):H289-98.
38. Stromer H, de Groot MC, Horn M, Faul C, Leupold A, Morgan JP, et al. Na(+)/H(+) exchange inhibition with HOE642 improves postischemic recovery due to attenuation of Ca(2+) overload and prolonged acidosis on reperfusion. Circulation. 2000;101:2749-55.
39. Linz W, Albus U, Crause P, Jung W, Weichert A, Scholkens BA, et al. Dose-dependent reduction of myocardial infarct mass in rabbits by the NHE-1 inhibitor cariporide (HOE 642). Clin Exp Hypertens. 1998;20:733-49.