Sodium/hydrogen-exchanger inhibition during cardioplegic arrest and cardiopulmonary bypass: An experimental study

Journal of Thoracic and Cardiovascular Surgery

Volumn 123, Issue 5, 2002, Pages 959-966

  Cox, Charles S ^a   Sauer, Henning ^a   Allen, Steven J ^a   Buja, L Maximilian ^a   Laine, Glen A ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOPLEGIC AGENT; ENIPORIDE; SODIUM PROTON EXCHANGE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL CATHETERIZATION; CARDIOPLEGIA; CARDIOPULMONARY BYPASS; CELL PH; CONTROLLED STUDY; DOG; HEART ARREST; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE BIOPSY; HEART OUTPUT; HEART PERFORMANCE; HEART PRELOAD; HEART STROKE VOLUME; NONHUMAN; PRIORITY JOURNAL; SODIUM TRANSPORT; STATISTICAL ANALYSIS; THERMODILUTION; TISSUE WATER; WATER TRANSPORT;

EID: 0036587141     PISSN: 00225223     EISSN: None     Source Type: Journal    
DOI: 10.1067/mtc.2002.120715     Document Type: Article

References (28)

1. Hearse DJ, Stewart DA, Braimbridge MV, Cellular protection during myocardial ischemia: the development and characterization of a procedure for the induction of reversible ischemic arrest. Circulation. 1976;54:193-202.
2. Mehlhorn U, Davis KL, Burke EJ, Adams D, Laine GA, Allen SJ. Impact of cardiopulmonary bypass and cardioplegic arrest on myocardial lymphatic function. Am J Physiol. 1995;268:H178-83.
3. Mehlhorn U, Allen SJ, Davis KL, Geissler HJ, Warters RD, de Vivie ER, Increasing the colloid osmotic pressure of cardiopulmonary bypass prime and normothermic blood cardioplegia minimizes myocardial oedema and prevents cardiac dysfunction. Cardiovasc Surg. 1998;6:274-81.
4. Mehlhorn U, Allen SJ, Adams DL, Davis KL, Gogola GR, Warters RD. Cardiac surgical conditions induced by β-blockade: effect on myocardial fluid balance. Ann Thorac Surg. 1996;62:143-50.
5. Allen SJ, Geissler HJ, Davis KL, Gogola GR, Warters RD, de Vivie ER. Augmenting cardiac contractility hastens myocardial edema resolution after cardiopulmonary bypass and cardioplegic arrest. Anesth Analg. 1997;85:987-92.
6. Laine GA, Allen SJ. Left ventricular myocardial edema- Lymph flow, interstitial fibrosis and cardiac function. Circ Res. 1991;68:1713-21.
7. Choy IO, Schepkin VD, Budinger TF, Obayashi DY, Young JN, DeCampli WM. Effects of specific sodium/hydrogen exchange inhibitor during cardioplegic arrest. Ann Thorac Surg. 1997;64:94-9.
8. + exchange inhibition in ischemic reperfused porcine hearts. Circulation. 1995;92:912-7.
9. 2+ overload in isolated perfused rabbit heart. Circulation. 1994;89:87-98.
10. + exchange and reperfusion arrhythmias: protection by intracoronary infusion of a novel inhibitor. Am J Physiol. 1994;267:H2430-40.
11. + exchange in ischemia-reperfusion. Basic Res Cardiol. 1996;91:191-202.
12. Pierce GN, Czubryt MP. The contribution of ionic imbalance to ischemia/reperfusion-induced injury. J Mol Cell Cardiol. 1995;27:53-63.
13. + exchange blockers EIPA, HOE642, and EMD96785. In: Proceedings of the 5th International Symposium of Magnetic Resonance in Cardiovascular Research. In press.
14. + exchange occurring during hypoxia in the genesis of reoxygenation-induced myocardial oedema. J Mol Cell Cardiol. 1997;29:1167-75.
15. Tritto FP, Inserte J, Garcia-Dorado D, Ruiz-Meana M, Soler-Soler J. Sodium/hydrogen exchanger inhibition reduces myocardial reperfusion edema after normothermic cardioptegia. J Thorac Cardiovasc Surg. 1998;115:709-15.
16. + exchanger attenuates neutrophil-mediated reperfusion injury. Ann Thorac Surg. 1995;60:377-81.
17. Muntz KH, Hagler HK, Boulas HJ, Willerson JT. Buja LM. Redistribution of catecholamines in the ischemic zone of the dog heart. Am J Pathol. 1984;114:64-78.
18. Bradley PP, Priebat DA, Christensen RD, Rothstein GR. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol. 1982;78:206-10.
19. Mullane KM, Kraemer R, Smith G. Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium. J Pharmacol Methods. 1985;14:157-60.
20. Bretschneider HJ, Hubner G, Knoll D. Myocardial resistance and tolerance to ischemia: physiological and biochemical basis. J Cardiovasc Surg. 1975;16:241-60.
21. + antiport during hypothermic ischemia: multinuclear NMR studies of rat hearts. J Mol Cell Cardiol. 1996;28:589-601.
22. + antiport: modulation by ATP and role in cell volume regulation. J Exp Biol. 1994;196:389-404.
23. Ludwig LL, Schertel ER, Pratt JW, McClure DE, Ying AJ, Heck CF, et al. Impairement of left ventricular function by acute cardiac lymphatic obstruction. Cardiovasc Res. 1997;33:164-71.
24. Miyamoto M, McClure DE, Schertel ER, Andrews PJ, Jones GA, Pratt JW, et al. Effects of hypoproteinemia-induced myocardial edema on left ventricular function. Am J Physiol. 1998;274:H937-44.
25. Laine GA, Allen SJ. Left ventricular myocardial edema. Circ Res. 1991;68:1713-21.
26. + exchanger in the mammalian myocardium. J Mol Cell Cardiol. 1997;29:1991-7.
27. Opie LH, Coetzee WA. Role of calcium ions in reperfusion arrythmias: relevance to pharmacologic intervention. Cardiovasc Drugs Ther. 1988;2:623-36.
28. Gumina RJ, Mizumura T, Beier N. A new sodium/hydrogen exchange inhibitor, EMD 85131, limits infarct size in dogs when administered before and after coronary artery occlusion. J Pharmacol Exp Ther. 1998;286:175-83.