Activating mutations of c-kit at codon 816 confer drug resistance in human leukemia cells

Leukemia and Lymphoma

Volumn 41, Issue 5-6, 2001, Pages 513-522

  Ning, Z Q ^a   Li, J ^a   Arceci, R J ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Apoptosis; C kit; Drug Resistance; Mutation; Proliferation; Stem cell factor

Indexed keywords

ACRIDINE ORANGE; ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENT; ASPARTIC ACID DERIVATIVE; BINDING PROTEIN; CELL ENZYME; COMPLEMENTARY DNA; CYTOKINE; CYTOTOXIC AGENT; DNA; DNA FRAGMENT; HEXADIMETHRINE BROMIDE; IMMUNOGLOBULIN; INTERLEUKIN 3; MESSENGER RNA; NEOMYCIN; OLIGONUCLEOTIDE; PHOSPHOTRANSFERASE; PHOSPHOTYROSINE; RADIOACTIVE MATERIAL; RECOMBINANT STEM CELL FACTOR; RESTRICTION ENDONUCLEASE; SODIUM CHLORIDE; STEEL FACTOR; STEM CELL FACTOR; STEM CELL FACTOR RECEPTOR; THYMIDINE; TRITIUM; TYROSINE KINASE RECEPTOR; UNINDEXED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CELL CULTURE; CELL GROWTH; CELL PROLIFERATION; CELL STIMULATION; CELL SURVIVAL; CHILD; CHILDHOOD LEUKEMIA; CODON; CONTROLLED STUDY; GENE ACTIVATION; GENE MUTATION; GENETIC ANALYSIS; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IONIZING RADIATION; LEUKEMIA CELL LINE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

EID: 0034895284     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428190109060342     Document Type: Review

References (31)

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6. The hematopoietic growth factor KL is encoded by the S1 locus and is the ligand of the c-kit receptor, the gene product of the W locus
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14. Ligand-independent activation of c-kit receptor tyrosine kinase in a murine mastocytoma cell line P-815 generated by a point mutation
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