Immunoglobulin-free light chains elicit immediate hypersensitivity-like responses

Nature Medicine

Volumn 8, Issue 7, 2002, Pages 694-701

  Redegeld, Frank A ^a   Van der Heijden, Maurice W ^a   Kool, Mirjam ^a   Heijdra, Bianca M ^a   Garssen, Johan ^b   Kraneveld, Aletta D ^a   Van Loveren, Henk ^b   Roholl, Paul ^b   Saito, Takashi ^c   Verbeek, J Sjef ^d   Claassens, Jill ^d   Koster, Andries S ^a   Nijkamp, Frans P ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^c CHIBA UNIVERSITY   (Japan)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALANYLHISTIDYLTRYPTOPHYLSERYLGLYCYLHISTIDYLCYSTEINYLCYSTEINYLLEUCINE; F 991; FC RECEPTOR; HAPTEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN LIGHT CHAIN; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTACT SENSITIVITY; CONTROLLED STUDY; DRUG EFFECT; HYPERSENSITIVITY REACTION; IMMUNE RESPONSE; IMMUNOSTIMULATION; MAST CELL DEGRANULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN ANAPHYLAXIS;

ANIMALS; EDEMA; HAPTENS; HUMANS; HYPERSENSITIVITY, IMMEDIATE; IMMUNOGLOBULIN LIGHT CHAINS; MAST CELLS; MICE; MICE, INBRED STRAINS; PASSIVE CUTANEOUS ANAPHYLAXIS;

ANIMALIA;

EID: 0036065632     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm722     Document Type: Article

References (45)

1. Induction and regulation of the IgE response
2. Active anaphylaxis in IgE-deficient mice
3. Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc γRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis
4. Immune serum from mice contact-sensitized with picryl chloride contains an antigen-specific T cell factor that transfers immediate cutaneous reactivity
5. Evidence by radioimmunoassay that mitogen-activated human blood mononuclear cells secrete significant amounts of light chain Ig unassociated with heavy chain
6. Synthesis of excess light chains of γ globulin by rabbit lymph node cells
7. Relative rates of synthesis of immunoglobulins and light chains in rabbit spleen cells during secondary response
8. Free immunoglobulin light chain synthesis by human foetal liver and cord blood lymphocytes
9. The renal handling of low molecular weight proteins. II. Disorders of serum protein catabolism in patients with tubular proteinuria, the nephrotic syndrome, or uremia
10. Specific binding activity of isolated light chains of antibodies
11. A simpler sort of antibody
12. Antigen recognition by an antibody light chain
13. An immunoglobulin light chain dimer with CD4 antigen specificity
14. Binding of 2, 4-dinitrophenyl derivatives by the light chain dimer obtained from immunoglobulin A produced by MOPC-315 mouse myeloma
15. Contributions of heavy and light chains of rabbit immunoglobulin G to antibody activity. I. Binding studies on isolated heavy and light chains
16. Similar binding properties of peptide ligands for a human immunoglobulin and its light chain dimer
17. Monoclonal antibody light chain with prothrombinase activity
18. Proteolytic activity of an antibody light chain
19. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene
20. Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival
21. Regulation of mast cell survival by IgE
22. IgE enhances mouse mast cell Fc(epsilon)RI expression in vitro and in vivo: Evidence for a novel amplification mechanism in IgE-dependent reactions
23. IgE antibody up-regulates high affinity IgE binding on murine bone marrow-derived mast cells
24. Critical role for cholesterol in Lyn-mediated tyrosine phosphorylation of FcepsilonRI and their association with detergent-resistant membranes
25. The antigen-binding T cell factor PCI-F sensitizes mast cells for in vitro release of serotonin. Comparison with monoclonal IgE antibody
26. Localization of a single binding site for immunoglobulin light chains on human Tamm-Horsfall glycoprotein
27. Required early complement activation in contact sensitivity with generation of local CS-dependent chemotactic activity, and late T cell interferon γ. A possible initiating role of B cells
28. FcR γ chain deletion resuits in pleiotrophic effector cell defects
29. Paired immunoglobulin-like receptor (PIR)-A is involved in activating mast cells through its association with Fc receptor γ chain
30. Stimulatory function of gp49A, a murine Ig-like receptor, in rat basophilic leukemia cells
31. Identification and characterization of a novel surface antigen gene induced in mast cells activated through the high affinity IgE receptor
32. Antibodies against human CD63 activate transfected rat basophilic leukemia (RBL-2H3) cells
33. Critical protective role of mast cells in a model of acute septic peritonitis
34. Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2
35. Mast cells are essential for early onset and severe disease in a murine model of multiple sclerosis
36. Mast cell activation and its relation to proinflammatory cytokine production in the rheumatoid lesion
37. Delayed-type hypersensitivity in mast cell-deficient mice: Dependence on platelets for expression of contact sensitivity
38. B-1 B cell IgM antibody initiates T cell elicitation of contact sensitivity
39. Free κ and λ light chain levels in the cerebrospinal fluid of patients with multiple sclerosis and other neurological diseases
40. High incidence of free monoclonal λ light chains in the sera of patients with Sjogren's syndrome
41. Free light chains of immunoglobulins in serum from patients with rheumatoid arthritis, sarcoidosis, chronic infections and pulmonary cancer
42. Elevated mast cell tryptase in cerebrospinal fluid of multiple sclerosis patients
43. Mast cells in rheumatic disorders: Mastermind or workhorse?
44. Stem cell factor and interleukin-4 induce murine bone marrow cells to develop into mast cells with connective tissue type characteristics in vitro
45. The role of stem cell factor (c-kit ligand) and inflammatory cytokines in pulmonary mast cell activation