Stabilizing peptide fusion for solving the stability and solubility problems of therapeutic proteins

Pharmaceutical Research

Volumn 22, Issue 10, 2005, Pages 1735-1746

  Eui, Nam Lee ^a   Young, Mok Kim ^a   Hye, Ja Lee ^a   Sang, Woo Park ^a   Han, Young Jung ^b   Jae, Myun Lee ^b   Ahn, Yong Ho ^c   Kim, Jongsun ^b,c  

^a ATGen Inc   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c Yonsei University   (South Korea)

Author keywords

Protein aggregation; Protein solubility; Protein stability; Stabilizing peptide; Therapeutic proteins

Indexed keywords

ACIDIC TAIL OF SYNUCLEIN PROTEIN; GRANULOCYTE COLONY STIMULATING FACTOR; HUMAN GROWTH HORMONE; HYBRID PROTEIN; LEPTIN; PROTEIN; STABILIZING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG HALF LIFE; DRUG SOLUBILITY; DRUG STABILITY; FREEZE THAWING; HEAT STRESS; IN VIVO STUDY; MALE; MECHANICAL STRESS; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; RAT; THERMOSTABILITY;

ALPHA-SYNUCLEIN; ANIMALS; DRUG STABILITY; DRUG STORAGE; GRANULOCYTE COLONY-STIMULATING FACTOR; HEAT; HUMAN GROWTH HORMONE; HUMANS; MALE; PEPTIDES; PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT FUSION PROTEINS; SOLUBILITY;

EID: 25144512402     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-005-6489-4     Document Type: Article

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