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Volumn 28, Issue 3, 2004, Pages 253-256

Molecular Pathology of Pancreatic Cancer: In Quest of Tumor Suppressor Genes

Author keywords

18q; Comparative genomic hybridization; DUSP6 MKP 3; Fluorescence in situ hybridization; Loss of heterozygosity; Tumor suppressor gene

Indexed keywords

MICROSATELLITE DNA;

EID: 1842535106     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006676-200404000-00007     Document Type: Review
Times cited : (19)

References (27)
  • 1
    • 0032933928 scopus 로고    scopus 로고
    • The prognostic significance of lymph node metastasis and intrapancreatic perineural invasion in pancreatic cancer after curative resection
    • Ozaki H, Hiraoka T, Mizumoto R, et al. The prognostic significance of lymph node metastasis and intrapancreatic perineural invasion in pancreatic cancer after curative resection. Surg Today. 1999;29:16-22.
    • (1999) Surg Today , vol.29 , pp. 16-22
    • Ozaki, H.1    Hiraoka, T.2    Mizumoto, R.3
  • 2
    • 0030919992 scopus 로고    scopus 로고
    • Frequent gain of copy number on the long arm of chromosome 20 in human pancreatic adenocarcinoma
    • Fukushige S, Waldman FM, Kimura M, et al. Frequent gain of copy number on the long arm of chromosome 20 in human pancreatic adenocarcinoma. Genes Chromosomes Cancer. 1997;19:161-169.
    • (1997) Genes Chromosomes Cancer , vol.19 , pp. 161-169
    • Fukushige, S.1    Waldman, F.M.2    Kimura, M.3
  • 3
    • 0029854322 scopus 로고    scopus 로고
    • Detailed deletion mapping on chromosome arm 12q in human pancreatic adenocarcinoma: Identification of a 1-cM region of common allelic loss
    • Kimura M, Abe T, Sunamura M, et al. Detailed deletion mapping on chromosome arm 12q in human pancreatic adenocarcinoma: Identification of a 1-cM region of common allelic loss. Genes Chromosomes Cancer. 1996; 17:88-93.
    • (1996) Genes Chromosomes Cancer , vol.17 , pp. 88-93
    • Kimura, M.1    Abe, T.2    Sunamura, M.3
  • 4
    • 15144342086 scopus 로고    scopus 로고
    • Identification of two common regions of allelic loss in chromosome arm 12q in human pancreatic cancer
    • Kimura M, Furukawa T, Abe T, et al. Identification of two common regions of allelic loss in chromosome arm 12q in human pancreatic cancer. Cancer Res. 1998;58:2456-2460.
    • (1998) Cancer Res , vol.58 , pp. 2456-2460
    • Kimura, M.1    Furukawa, T.2    Abe, T.3
  • 5
    • 0344141317 scopus 로고    scopus 로고
    • Identification of three commonly deleted regions on chromosome arm 6q in human pancreatic cancer
    • Abe T, Makino N, Furukawa T, et al. Identification of three commonly deleted regions on chromosome arm 6q in human pancreatic cancer. Genes Chromosomes Cancer. 1999;25:60-64.
    • (1999) Genes Chromosomes Cancer , vol.25 , pp. 60-64
    • Abe, T.1    Makino, N.2    Furukawa, T.3
  • 6
    • 0027743438 scopus 로고
    • Pancreatic adenocarcmomas frequently show p53 gene mutations
    • Scarpa A, Capelli P, Mukai K, et al. Pancreatic adenocarcmomas frequently show p53 gene mutations. Am J Pathol. 1993;142:1534-1543.
    • (1993) Am J Pathol , vol.142 , pp. 1534-1543
    • Scarpa, A.1    Capelli, P.2    Mukai, K.3
  • 7
    • 0028059330 scopus 로고
    • Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
    • Caldas C, Hahn SA, da Costa LT, et al. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat Genet. 1994;8:27-32.
    • (1994) Nat Genet , vol.8 , pp. 27-32
    • Caldas, C.1    Hahn, S.A.2    Da Costa, L.T.3
  • 8
    • 0030593038 scopus 로고    scopus 로고
    • DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
    • Hahn SA, Schutte M, Hoque AT, et al. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science. 1996;271:350-353.
    • (1996) Science , vol.271 , pp. 350-353
    • Hahn, S.A.1    Schutte, M.2    Hoque, A.T.3
  • 9
    • 14444284330 scopus 로고    scopus 로고
    • Tumor-suppressive pathways in pancreatic carcinoma
    • Rozenblum E, Schutte M, Goggins M, et al. Tumor-suppressive pathways in pancreatic carcinoma. Cancer Res. 1997;57:1731-1734.
    • (1997) Cancer Res , vol.57 , pp. 1731-1734
    • Rozenblum, E.1    Schutte, M.2    Goggins, M.3
  • 10
    • 0033869735 scopus 로고    scopus 로고
    • Association of poor prognosis with loss of 12q, 17p, and 18q, and concordant loss of 6q/17p and 12q/18q in human pancreatic ductal adenocarcinoma
    • Yatsuoka T, Sunamura M, Furukawa T, et al. Association of poor prognosis with loss of 12q, 17p, and 18q, and concordant loss of 6q/17p and 12q/18q in human pancreatic ductal adenocarcinoma. Am J Gastroenretol. 2000;95:2080-2085.
    • (2000) Am J Gastroenretol , vol.95 , pp. 2080-2085
    • Yatsuoka, T.1    Sunamura, M.2    Furukawa, T.3
  • 11
    • 0032190218 scopus 로고    scopus 로고
    • Loss of chromosome 18q is an early event in pancreatic ductal tumors
    • Fukushige S, Furukawa T, Satoh K, et al. Loss of chromosome 18q is an early event in pancreatic ductal tumors. Cancer Res. 1998;58:4222-4226.
    • (1998) Cancer Res , vol.58 , pp. 4222-4226
    • Fukushige, S.1    Furukawa, T.2    Satoh, K.3
  • 12
    • 0034890274 scopus 로고    scopus 로고
    • Isolation and characterization of the human gene homologous to the Drosophila headcase (hde) gene in chromosome bands 6q23-q24, a region of common deletion in human pancreatic cancer
    • Makino N, Yamato T, Inoue H, et al. Isolation and characterization of the human gene homologous to the Drosophila headcase (hde) gene in chromosome bands 6q23-q24, a region of common deletion in human pancreatic cancer. DNA Seq. 2001;11:547-553.
    • (2001) DNA Seq , vol.11 , pp. 547-553
    • Makino, N.1    Yamato, T.2    Inoue, H.3
  • 13
    • 0034886170 scopus 로고    scopus 로고
    • Human BAC contig covering the deleted region in pancreatic cancer at 12q21
    • Youssef EM, Kaneko K, Yatsuoka T, et al. Human BAC contig covering the deleted region in pancreatic cancer at 12q21. DNA Seq. 2001;11:541-546.
    • (2001) DNA Seq , vol.11 , pp. 541-546
    • Youssef, E.M.1    Kaneko, K.2    Yatsuoka, T.3
  • 14
    • 0032427885 scopus 로고    scopus 로고
    • Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer
    • Furukawa T, Yatsuoka T, Youssef EM, et al. Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer. Cytogenet Cell Genet. 1998;82:156-159.
    • (1998) Cytogenet Cell Genet , vol.82 , pp. 156-159
    • Furukawa, T.1    Yatsuoka, T.2    Youssef, E.M.3
  • 15
    • 0038243934 scopus 로고    scopus 로고
    • Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer
    • Furukawa T, Sunamura M, Motoi F, et al. Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer. Am J Pathol. 2003;162:1807-1815.
    • (2003) Am J Pathol , vol.162 , pp. 1807-1815
    • Furukawa, T.1    Sunamura, M.2    Motoi, F.3
  • 16
    • 0030028222 scopus 로고    scopus 로고
    • MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase
    • Muda M, Boschert U, Dickinson R, et al. MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase. J Biol Chem. 1996;271:4319-4326.
    • (1996) J Biol Chem , vol.271 , pp. 4319-4326
    • Muda, M.1    Boschert, U.2    Dickinson, R.3
  • 17
    • 0029905354 scopus 로고    scopus 로고
    • Differential regulation of the MAP, SAP and RK/p38 kinases by Pystl, a novel cytosolic dual-specificity phosphatase
    • Groom LA, Sneddon AA, Alessi DR, et al. Differential regulation of the MAP, SAP and RK/p38 kinases by Pystl, a novel cytosolic dual-specificity phosphatase. EMBO J. 1996;15:3621-3632.
    • (1996) EMBO J , vol.15 , pp. 3621-3632
    • Groom, L.A.1    Sneddon, A.A.2    Alessi, D.R.3
  • 18
    • 0024292722 scopus 로고
    • Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
    • Almoguera C, Shibata D, Forrester K, et al. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell. 1988;53:549-554.
    • (1988) Cell , vol.53 , pp. 549-554
    • Almoguera, C.1    Shibata, D.2    Forrester, K.3
  • 19
    • 0028266658 scopus 로고
    • Varying grades of epithelial atypia in the pancreatic ducts of humans. Classification based on morphometry and multivariate analysis and correlated with positive reactions of carcinoembryonic antigen
    • Furukawa T, Chiba R, Kobari M, et al. Varying grades of epithelial atypia in the pancreatic ducts of humans. Classification based on morphometry and multivariate analysis and correlated with positive reactions of carcinoembryonic antigen. Arch Pathol Lab Med. 1994;118:227-234.
    • (1994) Arch Pathol Lab Med , vol.118 , pp. 227-234
    • Furukawa, T.1    Chiba, R.2    Kobari, M.3
  • 20
    • 0037517632 scopus 로고
    • Reproducible categorization of atypia in pancreatic duct epithelia based on morphometry and cluster analysis, correlating with CEA-positive reactions and Ki-ras gene alterations
    • Furukawa T, Chiba R, Kobari M, et al. Reproducible categorization of atypia in pancreatic duct epithelia based on morphometry and cluster analysis, correlating with CEA-positive reactions and Ki-ras gene alterations. Ann Cancer Res Ther. 1993;2:121-122.
    • (1993) Ann Cancer Res Ther , vol.2 , pp. 121-122
    • Furukawa, T.1    Chiba, R.2    Kobari, M.3
  • 21
    • 0028875562 scopus 로고
    • Allelotype of pancreatic adenocarcinoma using xenograft enrichment
    • Hahn SA, Seymour AB, Hoque AT, et al. Allelotype of pancreatic adenocarcinoma using xenograft enrichment. Cancer Res. 1995;55:4670-4675.
    • (1995) Cancer Res , vol.55 , pp. 4670-4675
    • Hahn, S.A.1    Seymour, A.B.2    Hoque, A.T.3
  • 22
    • 0032478143 scopus 로고    scopus 로고
    • Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells
    • Zhou S, Buckhaults P, Zawel L, et al. Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells. Proc Natl Acad Sci U S A. 1998;95:2412-2416.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 2412-2416
    • Zhou, S.1    Buckhaults, P.2    Zawel, L.3
  • 23
    • 0242490137 scopus 로고    scopus 로고
    • Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells
    • Duda DG, Sunamura M, Lefter LP, et al. Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells. Oncogene. 2003;22:6857-6864.
    • (2003) Oncogene , vol.22 , pp. 6857-6864
    • Duda, D.G.1    Sunamura, M.2    Lefter, L.P.3
  • 24
    • 0035018972 scopus 로고    scopus 로고
    • Exclusion of SMAD4 mutation as an early genetic change in human pancreatic ductal tumorigenesis
    • Inoue H, Furukawa T, Sunamura M, et al. Exclusion of SMAD4 mutation as an early genetic change in human pancreatic ductal tumorigenesis. Genes Chromosomes Cancer. 2001;31:295-299.
    • (2001) Genes Chromosomes Cancer , vol.31 , pp. 295-299
    • Inoue, H.1    Furukawa, T.2    Sunamura, M.3
  • 25
    • 0034051009 scopus 로고    scopus 로고
    • Homozygous deletions inactivate DCC, but not MADH4/DPC4/SMAD4, in a subset of pancreatic and biliary cancers
    • Hilgers W, Song JJ, Haye M, et al. Homozygous deletions inactivate DCC, but not MADH4/DPC4/SMAD4, in a subset of pancreatic and biliary cancers. Genes Chromosomes Cancer. 2000;27:353-357.
    • (2000) Genes Chromosomes Cancer , vol.27 , pp. 353-357
    • Hilgers, W.1    Song, J.J.2    Haye, M.3
  • 26
    • 0036259301 scopus 로고    scopus 로고
    • Suppression of the tumorigenic phenotype by chromosome 18 transfer into pancreatic cancer cell lines
    • Lefter LP, Furukawa T, Sunamura M, et al. Suppression of the tumorigenic phenotype by chromosome 18 transfer into pancreatic cancer cell lines. Genes Chromosomes Cancer. 2002;34:234-242.
    • (2002) Genes Chromosomes Cancer , vol.34 , pp. 234-242
    • Lefter, L.P.1    Furukawa, T.2    Sunamura, M.3
  • 27
    • 0142250341 scopus 로고    scopus 로고
    • Inserting chromosome 18 into pancreatic cancer cells switches them to a dormant metastatic phenotype
    • Lefter LP, Sunamura M, Furukawa T, et al. Inserting chromosome 18 into pancreatic cancer cells switches them to a dormant metastatic phenotype. Clin Cancer Res. 2003;9:5044-5052.
    • (2003) Clin Cancer Res , vol.9 , pp. 5044-5052
    • Lefter, L.P.1    Sunamura, M.2    Furukawa, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.