-
2
-
-
0033057588
-
Delineation of selective cyclic GMP-dependent protein kinase Iα substrate and inhibitor peptides based on combinatorial peptide libraries on paper
-
Dostmann, W.R., Nicki, C., Thiel, S., Tsigelny, I., Frank, R. & Tegge, W. (1999) Delineation of selective cyclic GMP-dependent protein kinase Iα substrate and inhibitor peptides based on combinatorial peptide libraries on paper. J. Pharmacol. Ther. 82, 373-387.
-
(1999)
J. Pharmacol. Ther.
, vol.82
, pp. 373-387
-
-
Dostmann, W.R.1
Nicki, C.2
Thiel, S.3
Tsigelny, I.4
Frank, R.5
Tegge, W.6
-
3
-
-
0034687854
-
Highly specific, membrane-permanent peptide blockers of cGMP-dependent protein kinase Ialpha inhibit NO-induced cerebral dilation
-
Dostmann, W.R., Taylor, M.S., Nicki, C.K., Brayden, J.E. & Frank, R.T.W.J. (2000) Highly specific, membrane-permanent peptide blockers of cGMP-dependent protein kinase Ialpha inhibit NO-induced cerebral dilation. PIOC. Natl Acad. Sci. U S A 97, 14772-14777.
-
(2000)
PIOC. Natl. Acad. Sci. U S A
, vol.97
, pp. 14772-14777
-
-
Dostmann, W.R.1
Taylor, M.S.2
Nicki, C.K.3
Brayden, J.E.4
Frank, R.T.W.J.5
-
4
-
-
0031012892
-
Determination of the specific substrate sequence motifs of protein kinase C isozymes
-
Nishikawa, K., Toker, A., Johannes, F.J., Songyang, Z. & Cantley, L.C. (1997) Determination of the specific substrate sequence motifs of protein kinase C isozymes. J. Biol. Chem. 272, 952-960.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 952-960
-
-
Nishikawa, K.1
Toker, A.2
Johannes, F.J.3
Songyang, Z.4
Cantley, L.C.5
-
5
-
-
0034680838
-
Peptide and protein library screening defines optimal substrate motifs for AKT/PKB
-
Obata, T., Yaffe, M.B., Leparc, G.G., Piro, E.T., Maegawa, H., Kashiwagi, A., Kikkawa, R. & Cantley, L.C. (2000) Peptide and protein library screening defines optimal substrate motifs for AKT/PKB. J. Biol. Chem. 275, 36108-36115.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 36108-36115
-
-
Obata, T.1
Yaffe, M.B.2
Leparc, G.G.3
Piro, E.T.4
Maegawa, H.5
Kashiwagi, A.6
Kikkawa, R.7
Cantley, L.C.8
-
6
-
-
0030977516
-
Sequence specificity of C-terminal Src kinase (CSK) - A comparison with Src-related kinases c-Fgr and Lyn
-
Ruzzene, M., Songyang, Z., Marin, O., Donella-Deana, A., Brunati, A.M., Guerra, B., Agostinis, P., Cantley, L.C. & Pinna, L.A. (1997) Sequence specificity of C-terminal Src kinase (CSK) - a comparison with Src-related kinases c-Fgr and Lyn. Eur. J. Biochem. 246, 433-439.
-
(1997)
Eur. J. Biochem.
, vol.246
, pp. 433-439
-
-
Ruzzene, M.1
Songyang, Z.2
Marin, O.3
Donella-Deana, A.4
Brunati, A.M.5
Guerra, B.6
Agostinis, P.7
Cantley, L.C.8
Pinna, L.A.9
-
7
-
-
0028540405
-
Use of an oriented peptide library to determine the optimal substrates of protein kinases
-
Songyang, Z., Blechner, S., Hoagland, N., Hoekstra, M.F., Piwnica-Worms, H. & Cantley, L.C. (1994) Use of an oriented peptide library to determine the optimal substrates of protein kinases. Cuir. Biol. 4, 973-982.
-
(1994)
Cuir. Biol.
, vol.4
, pp. 973-982
-
-
Songyang, Z.1
Blechner, S.2
Hoagland, N.3
Hoekstra, M.F.4
Piwnica-Worms, H.5
Cantley, L.C.6
-
8
-
-
0343177223
-
A structural basis for substrate specificities of protein Ser/Thr kinases: Primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1
-
Songyang, Z., Lu, K.P., Kwon, Y.T., Tsai, L.H., Filhol, O., Cochet, C., Brickey, D.A., Soderling, T.R., Bartleson, C., Graves, D.J., DeMaggio, A.J., Hoekstra, M.F., Blenis, J., Hunter, T. & Cantley, L.C. (1996) A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1. Mol. Cell. Biol. 16, 6486-6493.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 6486-6493
-
-
Songyang, Z.1
Lu, K.P.2
Kwon, Y.T.3
Tsai, L.H.4
Filhol, O.5
Cochet, C.6
Brickey, D.A.7
Soderling, T.R.8
Bartleson, C.9
Graves, D.J.10
DeMaggio, A.J.11
Hoekstra, M.F.12
Blenis, J.13
Hunter, T.14
Cantley, L.C.15
-
9
-
-
0031608184
-
The use of peptide library for the determination of kinase peptide substrates
-
Songyang, Z. & Cantley, L.C. (1998) The use of peptide library for the determination of kinase peptide substrates. Methods Mol. Biol. 87, 87-98.
-
(1998)
Methods Mol. Biol.
, vol.87
, pp. 87-98
-
-
Songyang, Z.1
Cantley, L.C.2
-
10
-
-
0033828742
-
The crystal structure of a pyrrolinone-peptide hybrid ligand bound to the human class II MHC protein HLA-DR1
-
Lee, K.H., Olson, G.L., Bolin, D.R., Benowitz, A.B., Sprengler, P.A., Smith, A.B. III, Hirschmann, R.F. a Wiley, D.C. (2000) The crystal structure of a pyrrolinone-peptide hybrid ligand bound to the human class II MHC protein HLA-DR1. J. Am. Chem. Soc. 122, 8370-8375.
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 8370-8375
-
-
Lee, K.H.1
Olson, G.L.2
Bolin, D.R.3
Benowitz, A.B.4
Sprengler, P.A.5
Smith III, A.B.6
Hirschmann, R.F.7
Wiley, D.C.8
-
11
-
-
0028882977
-
Pyrrolinone-based HIV protease inhibitors, design, synthesis, and antiviral activity: Evidence for improved transport
-
Smith, A.B. III, Hirschmann, R.F., Pasternak, A., Guzman, M.C., Yokoyama, A., Sprengler, P.A., Darke, P.L., Emini, E. & Schleif, W.A. (1995) Pyrrolinone-based HIV protease inhibitors, design, synthesis, and antiviral activity: evidence for improved transport. J. Am. Chem. Soc. 117, 11113-11123.
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 11113-11123
-
-
Smith III, A.B.1
Hirschmann, R.F.2
Pasternak, A.3
Guzman, M.C.4
Yokoyama, A.5
Sprengler, P.A.6
Darke, P.L.7
Emini, E.8
Schleif, W.A.9
-
12
-
-
0030806489
-
An orally bioavailable pyrrolinone inhibitor of HIV-1 protease: Computational analysis and X-ray crystal structure of the enzyme complex
-
Smith, A.B. III, Hirschmann, R.F., Pasternak, A., Yao, W., Sprengler, P.A., Holloway, M.K., Kuo, L.C., Chen, Z., Darke, P.L. & Schleif, W.A. (1997) An orally bioavailable pyrrolinone inhibitor of HIV-1 protease: computational analysis and X-ray crystal structure of the enzyme complex. J. Med. Chem. 40, 2440-2444.
-
(1997)
J. Med. Chem.
, vol.40
, pp. 2440-2444
-
-
Smith III, A.B.1
Hirschmann, R.F.2
Pasternak, A.3
Yao, W.4
Sprengler, P.A.5
Holloway, M.K.6
Kuo, L.C.7
Chen, Z.8
Darke, P.L.9
Schleif, W.A.10
-
13
-
-
0032501418
-
Design, synthesis, and evaluation of a pyrrolinone-peptide hybrid ligand for the class II MHC protein HLA-DR1
-
Smith, A.B. III, Benowitz, A.B., Guzman, M.C., Sprengler, P.A., Hirschmann, R.F., Schweiger, E.J., Bolin, D.R., Nagy, Z., Campbell, R.M., Cox, D.C. & Olson, G.L. (1998) Design, synthesis, and evaluation of a pyrrolinone-peptide hybrid ligand for the class II MHC protein HLA-DR1. J. Am. Chem. Soc. 120, 12704-12705.
-
(1998)
J. Am. Chem. Soc.
, vol.120
, pp. 12704-12705
-
-
Smith III, A.B.1
Benowitz, A.B.2
Guzman, M.C.3
Sprengler, P.A.4
Hirschmann, R.F.5
Schweiger, E.J.6
Bolin, D.R.7
Nagy, Z.8
Campbell, R.M.9
Cox, D.C.10
Olson, G.L.11
-
14
-
-
0037740657
-
Design, synthesis, and biological evaluation of monopyrrolinine-based HIV-1 protease inhibitors
-
Smith, A.B., Cantin, L.D., Pasternak, A., Guise-Zawacki, L., Yao, W., Charnley, A.K., Barbosa, J., Sprengeler, P.A., Hirschmann, R., Munshi, S., Olsen, D.B., Schleif, W.A. & Kuo, L.C. (2003) Design, synthesis, and biological evaluation of monopyrrolinine-based HIV-1 protease inhibitors. J. Med. Chem. 46, 1831-1844.
-
(2003)
J. Med. Chem.
, vol.46
, pp. 1831-1844
-
-
Smith, A.B.1
Cantin, L.D.2
Pasternak, A.3
Guise-Zawacki, L.4
Yao, W.5
Charnley, A.K.6
Barbosa, J.7
Sprengeler, P.A.8
Hirschmann, R.9
Munshi, S.10
Olsen, D.B.11
Schleif, W.A.12
Kuo, L.C.13
-
15
-
-
0037153201
-
1 antagonist
-
1 antagonist. J. Med. Chem. 45, 5353-5357.
-
(2002)
J. Med. Chem.
, vol.45
, pp. 5353-5357
-
-
Halab, L.1
Becker, J.A.2
Darula, Z.3
Tourwe, D.4
Kieffer, B.L.5
Simonin, F.6
Lubell, W.D.7
-
16
-
-
14444269454
-
Non-peptide RGD surrogates which mimic a Gly-Asp beta-Turn: Potent antagonists of platelet glycoprotein Ilb-IIIa
-
Fisher, M.J., Gunn, B., Harms, C.S., Kline, A.D., Mullaney, J.T., Nunes, A., Scarborough, R.M., Arfsten, A.E., Skelton, M.A., Um, S.L., Utterback, B.G. & Jakubowski, J.A. (1997) Non-peptide RGD surrogates which mimic a Gly-Asp beta-Turn: potent antagonists of platelet glycoprotein Ilb-IIIa. J. Med. Chem. 40, 2085-2101.
-
(1997)
J. Med. Chem.
, vol.40
, pp. 2085-2101
-
-
Fisher, M.J.1
Gunn, B.2
Harms, C.S.3
Kline, A.D.4
Mullaney, J.T.5
Nunes, A.6
Scarborough, R.M.7
Arfsten, A.E.8
Skelton, M.A.9
Um, S.L.10
Utterback, B.G.11
Jakubowski, J.A.12
-
17
-
-
17744406303
-
Fused bicyclic Gly-Asp beta-turn mimics with potent affinity for GPIIb-IIa. Exploration of the arginine isostere
-
Fisher, M.J., Giese, U., Harms, C.S., Kinnick, M.D., Lindstrom, T.D., McCowan, J.R., Mest, H.J., Morin, J.M., Mullaney, J.T., Paal, M., Rapp, A., Ruhter, G., Ruterbories, K.J., Sail, D.J., Scarborough, R.M., Schotten, T., Stenzel, W., Towner, R.D., Um, S.L., Utterback, B.G., Wyss, V.L. & Jakubowski, J.A. (2,000) Fused bicyclic Gly-Asp beta-turn mimics with potent affinity for GPIIb-IIa. Exploration of the arginine isostere. Bioorg. Med. Chem. Lett. 10, 385-389.
-
(2000)
Bioorg. Med. Chem. Lett.
, vol.10
, pp. 385-389
-
-
Fisher, M.J.1
Giese, U.2
Harms, C.S.3
Kinnick, M.D.4
Lindstrom, T.D.5
McCowan, J.R.6
Mest, H.J.7
Morin, J.M.8
Mullaney, J.T.9
Paal, M.10
Rapp, A.11
Ruhter, G.12
Ruterbories, K.J.13
Sail, D.J.14
Scarborough, R.M.15
Schotten, T.16
Stenzel, W.17
Towner, R.D.18
Um, S.L.19
Utterback, B.G.20
Wyss, V.L.21
Jakubowski, J.A.22
more..
-
18
-
-
0037420818
-
Nonpeptide RGD antagonists: A novel class of mimetics, the 5,8-disubstituted 1-azabicyclo[5.2.0]nonan-2-one lactam
-
Bourguet, E., Baneres, J.L., Parello, J., Lusinchi, X., Girard, J.P. & Vidal, J.P. (2003) Nonpeptide RGD antagonists: a novel class of mimetics, the 5,8-disubstituted 1-azabicyclo[5.2.0]nonan-2-one lactam. Bioorg. Med. Chem. Lett. 13, 1561-1564.
-
(2003)
Bioorg. Med. Chem. Lett.
, vol.13
, pp. 1561-1564
-
-
Bourguet, E.1
Baneres, J.L.2
Parello, J.3
Lusinchi, X.4
Girard, J.P.5
Vidal, J.P.6
-
19
-
-
0026326821
-
Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase
-
Knighton, D.R., Zheng, J., Ten Eyck, L.F., Xuong, N.H., Taylor, S.S. & Sowadski, J.M. (1991) Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science 2,53, 414-42, 0.
-
(1991)
Science
, vol.253
, pp. 414-420
-
-
Knighton, D.R.1
Zheng, J.2
Ten Eyck, L.F.3
Xuong, N.H.4
Taylor, S.S.5
Sowadski, J.M.6
-
20
-
-
0033224309
-
The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases
-
Brown, N.R., Noble, M.E., Endicott, J.A. & Johnson, L.N. (1999) The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases. Nat. Cell Biol. 1, 438-443.
-
(1999)
Nat. Cell Biol.
, vol.1
, pp. 438-443
-
-
Brown, N.R.1
Noble, M.E.2
Endicott, J.A.3
Johnson, L.N.4
-
21
-
-
0030812650
-
The crystal structure of a phosphorylase kinase peptide substrate complex: Kinase substrate recognition
-
Lowe, E.D., Noble, M.E., Skamnaki, V.T., Oikonomakos, N.G., Owen, D.J. & Johnson, L.N. (1997) The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition. EMBO J. 16, 6646-6658.
-
(1997)
EMBO J.
, vol.16
, pp. 6646-6658
-
-
Lowe, E.D.1
Noble, M.E.2
Skamnaki, V.T.3
Oikonomakos, N.G.4
Owen, D.J.5
Johnson, L.N.6
-
22
-
-
0035165210
-
Mechanism-based design of a protein kinase inhibitor
-
Parang, K., Till, J.H., Ablooglu, AJ., Kohanski, R.A., Hubbard, S.R. & Cole, P.A. (2001) Mechanism-based design of a protein kinase inhibitor. Nat. Struct. Biol. 8, 16-18.
-
(2001)
Nat. Struct. Biol.
, vol.8
, pp. 16-18
-
-
Parang, K.1
Till, J.H.2
Ablooglu, A.J.3
Kohanski, R.A.4
Hubbard, S.R.5
Cole, P.A.6
-
23
-
-
0025258896
-
Identification by mass spectrometry of threonine 97 in bovine myelin basic protein as a specific phosphorylation site for mitogen-activated protein kinase
-
Erickson, A.K., Payne, D.M., Martino, P.A., Rossomando, A.J., Shabanowitz, J., Weber, M.J., Hunt, D.F. a Sturgill, T.W. (1990) Identification by mass spectrometry of threonine 97 in bovine myelin basic protein as a specific phosphorylation site for mitogen-activated protein kinase. J. Biol. Chem. 265, 19728-19735.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 19728-19735
-
-
Erickson, A.K.1
Payne, D.M.2
Martino, P.A.3
Rossomando, A.J.4
Shabanowitz, J.5
Weber, M.J.6
Hunt, D.F.7
Sturgill, T.W.8
-
24
-
-
0022617209
-
Substrate specificity of rat brain calcium-activated and phospholipid dependent protein kinase
-
Chan, K.F., Stoner, G.L., Hashim, G.A. & Huang, K.P. (1986) Substrate specificity of rat brain calcium-activated and phospholipid dependent protein kinase. Biochem. Biophys. Res. Commun. 134, 1358-1364.
-
(1986)
Biochem. Biophys. Res. Commun.
, vol.134
, pp. 1358-1364
-
-
Chan, K.F.1
Stoner, G.L.2
Hashim, G.A.3
Huang, K.P.4
-
25
-
-
0030603082
-
Conformational stability of proline oligomers
-
Zhang, R. & Madalengoitia, J.S. (1996) Conformational stability of proline oligomers. Tetrahedron Lett. 37, 6235-6238.
-
(1996)
Tetrahedron Lett.
, vol.37
, pp. 6235-6238
-
-
Zhang, R.1
Madalengoitia, J.S.2
-
26
-
-
0032577028
-
A(1,3) like strain as a key conformational control element in the design of poly-L-proline type II peptide mimics
-
Zhang, R., Brownewell, F.E. & Madalengoitia, J.S. (1998) A(1,3) like strain as a key conformational control element in the design of poly-L-proline type II peptide mimics. J. Am. Chem. Soc. 120, 3894-3902.
-
(1998)
J. Am. Chem. Soc.
, vol.120
, pp. 3894-3902
-
-
Zhang, R.1
Brownewell, F.E.2
Madalengoitia, J.S.3
-
27
-
-
0033593541
-
Design, synthesis and evaluation of poly-L-proline type II peptide mimics based on the 3-aza-bicyclo[3.i.o]hexane system
-
Zhang, R. & Madalengoitia, J.S. (1999) Design, synthesis and evaluation of poly-L-proline type II peptide mimics based on the 3-aza-bicyclo[3.i.o]hexane system. J. Org. Chem. 64, 330-331.
-
(1999)
J. Org. Chem.
, vol.64
, pp. 330-331
-
-
Zhang, R.1
Madalengoitia, J.S.2
-
28
-
-
0035951555
-
Poly-L-proline type II peptide mimics based on the 3-aza-bicyclo[3.1.0] hexane system
-
Marnai, A., Zhang, R., Natarajan, A. & Madalengoitia, J.S. (2001) Poly-L-proline type II peptide mimics based on the 3-aza-bicyclo[3.1.0]hexane system. J. Org. Chem. 66, 455-460.
-
(2001)
J. Org. Chem.
, vol.66
, pp. 455-460
-
-
Marnai, A.1
Zhang, R.2
Natarajan, A.3
Madalengoitia, J.S.4
-
29
-
-
0017189603
-
The X-Pro peptide bond as an NMR probe for conformational studies of flexible linear peptides
-
Grathwohl, C. & Wuthrich, K. (1976) The X-Pro peptide bond as an NMR probe for conformational studies of flexible linear peptides. Biopolymers 15, 2025-2041.
-
(1976)
Biopolymers
, vol.15
, pp. 2025-2041
-
-
Grathwohl, C.1
Wuthrich, K.2
-
30
-
-
0033593515
-
Cyclopropanation reactions of pyroglutamic acid-derived synthons with alkylidene transfer reagents
-
Zhang, R., Marnai, A. & Madalengoitia, J.S. (1999) Cyclopropanation reactions of pyroglutamic acid-derived synthons with alkylidene transfer reagents. J. Org. Chem. 64, 547-555.
-
(1999)
J. Org. Chem.
, vol.64
, pp. 547-555
-
-
Zhang, R.1
Marnai, A.2
Madalengoitia, J.S.3
-
31
-
-
0023907011
-
A new strategy for the chemical synthesis of peptides
-
Yajima, H., Fujii, N., Funakoshi, N., Watanabe, T., Murayama, E. & Otaka, A. (1998) A new strategy for the chemical synthesis of peptides. Tetrahedron 44, 805-819.
-
(1998)
Tetrahedron
, vol.44
, pp. 805-819
-
-
Yajima, H.1
Fujii, N.2
Funakoshi, N.3
Watanabe, T.4
Murayama, E.5
Otaka, A.6
-
32
-
-
2142650232
-
Unique inhibitory properties of the cell-permeable cGMP-dependent protein kinase inhibitor DT-2 reveal a novel mechanism of vasoregulation
-
Taylor, M.S., Okwuchukwuasanya, C., Nicki, C.K., Brayden, J.E. & Dostmann, W.R.G. (2004) Unique inhibitory properties of the cell-permeable cGMP-dependent protein kinase inhibitor DT-2 reveal a novel mechanism of vasoregulation. Mol Pharm. 65, 1111-1119.
-
(2004)
Mol. Pharm.
, vol.65
, pp. 1111-1119
-
-
Taylor, M.S.1
Okwuchukwuasanya, C.2
Nicki, C.K.3
Brayden, J.E.4
Dostmann, W.R.G.5
|