Fused bicyclic Gly-Asp β-turn mimics with potent affinity for GPIIb-IIIa. Exploration of the arginine isostere

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 4, 2000, Pages 385-389

  Fisher, Matthew J ^a   Giese, Ulrich ^b   Harms, Cathy S ^a   Kinnick, Michael D ^a   Lindstrom, Terry D ^a   McCowan, Jefferson R ^a   Mest, Hans Jürgen ^b   Morin Jr , John M ^a   Mullaney, Jeffrey T ^a   Paal, Michael ^b   Rapp, Achim ^b   Rühter, Gerd ^b   Ruterbories, Ken J ^a   Sall, Daniel J ^a   Scarborough, Robert M ^c   Schotten, Theo ^b   Stenzel, Wolfgang ^b   Towner, Richard D ^a   Um, Suzane L ^a   Utterback, Barbara G ^a   Wyss, Virginia L ^a   Jakubowski, Joseph A ^a   more..

^a ELI LILLY AND COMPANY   (United States)

^b Lilly Research Laboratories   (Germany)

^c MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDINE; ARGININE; ARGINYLGLYCYLASPARTIC ACID; BENZAMIDINE; FIBRINOGEN RECEPTOR; FIBRINOGEN RECEPTOR ANTAGONIST;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CHEMICAL MODIFICATION; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EXPOSURE; DRUG SYNTHESIS; IC 50; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ACETIC ACIDS; ADENOSINE DIPHOSPHATE; AMIDINES; ANIMALS; ARGININE; BENZAMIDINES; BIOLOGICAL AVAILABILITY; DRUG EVALUATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBRINOGEN; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PRODRUGS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RATS; STEREOISOMERISM; TETRALONES;

ANIMALIA;

EID: 17744406303     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00008-1     Document Type: Article

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