Microsomal formation of nitric oxide and cyanamides from non-physiological N-hydroxyguanidines: N-hydroxydebrisoquine as a model substrate

Biochemical Pharmacology

Volumn 58, Issue 3, 1999, Pages 439-445

  Clement, Bernd ^a   Boucher, Jean Luc ^b   Mansuy, Daniel ^a   Harsdorf, Angela ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Cyanamides; Cytochrome P 450; N hydroxy L arginine; N hydroxydebrisoquine; N hydroxyguanidine; Nitric oxide

Indexed keywords

ARGININE; CATALASE; CITRULLINE; CYANAMIDE; CYTOCHROME P450; DEBRISOQUINE; DEXAMETHASONE; HYDROGEN PEROXIDE; LINSIDOMINE; N HYDROXYARGININE; N HYDROXYDEBRISOQUINE; N HYDROXYGUANIDINE; NITRIC OXIDE; NITRIC OXIDE DONOR; OXYHEMOGLOBIN; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ARTICLE; CONTROLLED STUDY; ENZYME SUBSTRATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER MICROSOME METABOLISM; MALE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RABBIT; REACTION ANALYSIS;

ANIMALS; CATALASE; CYANAMIDE; CYTOCHROME P-450 ENZYME SYSTEM; DEBRISOQUIN; GUANIDINES; HUMANS; MICROSOMES, LIVER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXIDATION-REDUCTION; RABBITS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SUBCELLULAR FRACTIONS; SUPEROXIDE DISMUTASE; UREA;

EID: 0033049232     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(99)00102-1     Document Type: Article

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