Functional analysis of PTPN11/SHP-2 mutants identified in Noonan syndrome and childhood leukemia

Journal of Human Genetics

Volumn 50, Issue 4, 2005, Pages 192-202

  Niihori, Tetsuya ^a   Aoki, Yoko ^a   Ohashi, Hirofumi ^b   Kurosawa, Kenji ^c   Kondoh, Tatsuro ^d   Ishikiriyama, Satoshi ^e   Kawame, Hiroshi ^f   Kamasaki, Hotaka ^g   Yamanaka, Tsutomu ^h   Takada, Fumio ⁱ   Nishio, Kimio ^j   Sakurai, Masahiro ^a   Tamai, Hiroshi ^k   Nagashima, Tatsuro ^l   Suzuki, Yoichi ^a   Kure, Shigeo ^a   Fujii, Kunihiro ^a   Imaizumi, Masue ^m   Matsubara, Yoichi ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b SAITAMA CHILDREN'S MEDICAL CENTER   (Japan)

^c KANAGAWA CHILDREN'S MEDICAL CENTER   (Japan)

^d NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e SHIZUOKA CHILDREN'S HOSPITAL   (Japan)

^f NAGANO CHILDREN'S HOSPITAL   (Japan)

^g SAPPORO MEDICAL UNIVERSITY   (Japan)

^h Okazaki Women's University   (Japan)

ⁱ KITASATO UNIVERSITY   (Japan)

^j SEIREI HAMAMATSU GENERAL HOSPITAL   (Japan)

^k OSAKA MEDICAL COLLEGE   (Japan)

^l JIKEI UNIVERSITY HOSPITAL   (Japan)

^m MIYAGI CHILDREN S HOSPITAL   (Japan)

more..

Author keywords

Leukemia; Noonan syndrome; PTPN11; SHP 2; SHP2; Tyrosine phosphatase

Indexed keywords

PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE SHP 2;

ADOLESCENT; ANIMAL CELL; ARTICLE; CELL STRAIN COS7; CHILD; CHILDHOOD LEUKEMIA; CLINICAL ARTICLE; CODON; COMPARATIVE STUDY; ENZYME ACTIVITY; ENZYME ASSAY; FEMALE; FUNCTIONAL ASSESSMENT; GENE IDENTIFICATION; GENE MUTATION; GENETIC CODE; HUMAN; JUVENILE MYELOMONOCYTIC LEUKEMIA; LEUKEMOGENESIS; MALE; MISSENSE MUTATION; NONHUMAN; NOONAN SYNDROME; PATHOGENESIS; SOMATIC MUTATION; WILD TYPE;

ADOLESCENT; ADULT; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUKEMIA, MYELOID; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; NOONAN SYNDROME; PHENOTYPE; PROTEIN-TYROSINE-PHOSPHATASE; SRC HOMOLOGY DOMAINS;

EID: 21044458262     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10038-005-0239-7     Document Type: Article

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