Cysteine-scanning mutagenesis of serotonin transporter intracellular loop 2 suggests an α-helical conformation

Journal of Biological Chemistry

Volumn 280, Issue 35, 2005, Pages 30807-30813

  Zhang, Yuan Wei ^a   Rudnick, Gary ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CELLS; CONFORMATIONS; DRUG PRODUCTS; MOLECULAR BIOLOGY; PROTEINS; SENSITIVITY ANALYSIS;

INTRACELLULAR LOOP 2; SEROTONIN TRANSPORTER (SERT);

MUTAGENESIS;

2 (AMINOETHYL)METHANETHIOSULFONATE HYDROBROMIDE; 2BETA CARBOMETHOXY 3BETA (4 IODOPHENYL)TROPANE I 125; ALTROPANE; COCAINE DERIVATIVE; CYCLIC GMP DEPENDENT PROTEIN KINASE; ISOLEUCINE; PROTEIN KINASE C; SERINE; THIOMESYLIC ACID METHYL ESTER; TRYPTOPHAN; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; CHEMICAL MODIFICATION; CYSTEINE SCANNING MUTAGENESIS; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; REGULATORY MECHANISM; SEROTONIN RELEASE; SIGNAL TRANSDUCTION; TRANSPORT KINETICS;

AMINO ACID SEQUENCE; ANIMALS; CYSTEINE; ETHYL METHANESULFONATE; HELA CELLS; HUMANS; INDICATORS AND REAGENTS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MESYLATES; MOLECULAR SEQUENCE DATA; MUTAGENESIS; NERVE TISSUE PROTEINS; PROTEIN STRUCTURE, SECONDARY; RATS; SEQUENCE ALIGNMENT; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 24744459650     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M504087200     Document Type: Article

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