A Conformationally Sensitive Residue on the Cytoplasmic Surface of Serotonin Transporter

Journal of Biological Chemistry

Volumn 276, Issue 49, 2001, Pages 45933-45938

  Androutsellis Theotokis, Andreas ^b   Ghassemi, Farshid ^b   Rudnick, Gary ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOLOGICAL MEMBRANES; CELLS; POSITIVE IONS;

LIGANDS;

BIOCHEMISTRY;

2 (AMINOETHYL)METHANETHIOSULFONATE HYROBROMIDE; AMINO ACID; COCAINE; CYSTEINE; MONOVALENT CATION; POTASSIUM ION; SEROTONIN; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG; CARRIER PROTEIN; DRUG DERIVATIVE; LIGAND; MEMBRANE PROTEIN; MESYLIC ACID ETHYL ESTER; METHANETHIOSULFONATE ETHYLAMMONIUM;

ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOPLASM; DNA TEMPLATE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN TRANSPORT; ANIMAL; CHEMISTRY; GENETICS; METABOLISM; PROTEIN BINDING; RAT; SITE DIRECTED MUTAGENESIS;

CHEN;

ANIMAL; CARRIER PROTEINS; CYSTEINE; CYTOPLASM; ETHYL METHANESULFONATE; LIGANDS; MEMBRANE GLYCOPROTEINS; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN CONFORMATION; RATS;

EID: 0035824585     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M107462200     Document Type: Article

References (41)

1. Rudnick, G., and Clark, J. (1993) Biochim. Biophys. Acta 1144, 249-263
2. Amara, S., and Kuhar, M. (1993) Annu. Rev. Neurosci. 16, 73-93
3. Nelson, N. (1998) J. Neurochem. 71, 1785-1803
4. Uhl, G., and Johnson, P. (1994) J. Exp. Biol. 196, 229-236
5. Rudnick, G. (1998) J. Bioenerg. Biomembr. 30, 173-185
6. Boyer, W. (1992) Int. Clin. Psychopharmacol. 6, 5-12
7. Wall, S. C., Innis, R. B., and Rudnick, G. (1993) Mol. Pharmacol. 43, 264-270
8. Rudnick, G., and Wall, S. C. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 1817-1821
9. Guastella, J., Nelson, N., Nelson, H., Czyzyk, L., Keynan, S., Miedel, M., Davidson, N., Lester, H., and Kanner, B. I. (1990) Science 249, 1303-1306
10. Pacholczyk, T., Blakely, R., and Amara, S. (1991) Nature 350, 350-354
11. Shimada, S., Kitayama, S., Lin, C., Patel, A., Nanthakumar, E., Gregor, P., Kuhar, M., and Uhl, G. (1991) Science 254, 576-578
12. Usdin, T., Mezey, E., Chen, C., Brownstein, M., and Hoffman, B. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 11168-11171
13. Giros, B., el Mestikawy, S., Bertrand, L., and Caron, M. G. (1991) FEBS Lett. 295, 149-154
14. Mayser, W., Betz, H., and Schloss, P. (1991) FEBS Lett. 295, 203-206
15. Liu, Q.-R., Lopez-Corcuera, B., Nelson, H., Mandiyan, S., and Nelson, N. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 12145-12149
16. Liu, Q.-R., Lopez-Corcuera, B., Mandiyan, S., Nelson, H., and Nelson, N. (1993) J. Biol. Chem. 268, 22802-22808
17. Clark, J., Deutch, A., Gallipoli, P., and Amara, S. (1992) Neuron 9, 337-348
18. Borden, L., Smith, K., Hartig, P., Branchek, T., and Weinshank, R. (1992) J. Biol. Chem. 267, 21098-21104
19. Smith, K., Borden, L., Wang, C., Hartig, P., Branchek, T., and Weinshank, R. (1992) Mol. Pharmacol. 42, 563-569
20. Yamauchi, A., Uchida, S., Kwon, H., Preston, A., Robey, R., Garcia-Perez, A., Burg, M., and Handler, J. (1992) J. Biol. Chem. 267, 649-652
21. Kitayama, S., Shimada, S., Xu, H., Markham, L., Donovan, D., and Uhl, G. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 7782-7785
22. Rudnick, G. (1997) in Neurotransmitter Transporters: Structure, Function, and Regulation (Reith, M., ed) pp. 73-100, Humana Press, Totowa, NJ
23. Blakely, R., Berson, H., Fremeau, R., Caron, M., Peek, M., Prince, H., and Bradely, C. (1991) Nature 354, 66-70
24. Hoffman, B. J., Mezey, E., and Brownstein, M. J. (1991) Science 254, 579-580
25. Ramamoorthy, S., Bauman, A., Moore, K., Han, H., Yang-Feng, T., Chang, A., Ganapathy, V., and Blakely, R. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 2542-2546
26. Chen, J. G., Liu-Chen, S., and Rudnick, G. (1998) J. Biol. Chem. 273, 12675-12681
27. Chen, J. G., Liu-Chen, S., and Rudnick, G. (1997) Biochemistry 36, 1479-1486
28. Chen, J. G., Sachpatzidis, A., and Rudnick, G. (1997) J. Biol. Chem. 272, 28321-28327
29. Ferrer, J. V., and Javitch, J. A. (1998) Proc. Natl. Acad. Sci. U. S.A. 95, 9238-9243
30. Golovanevsky, V., and Kanner, B. I. (1999) J. Biol. Chem. 274, 23020-23026
31. Tate, C., and Blakely, R. (1994) J. Biol. Chem. 269, 26303-26310
32. Blakely, R. D., Clark, J. A., Rudnick, G., and Amara, S. G. (1991) Anal. Biochem. 194, 302-308
33. Stauffer, D. A., and Karlin, A. (1994) Biochemistry 33, 6840-6849
34. Holmgren, M., Liu, Y., Xu, Y., and Yellen, G. (1996) Neuropharmacology 35, 797-804
35. Humphreys, C. J., Wall, S. C., and Rudnick, G. (1994) Biochemistry 33, 9118-9125
36. Chen, J. G., and Rudnick, G. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 1044-1049
37. Smicun, Y., Campbell, S. D., Chen, M. A., Gu, H., and Rudnick, G. (1999) J. Biol. Chem. 274, 36058-36064
38. Barker, E. L., Perlman, M. A., Adkins, E. M., Houlihan, W. J., Pristupa, Z. B., Niznik, H. B., and Blakely, R. D. (1998) J. Biol. Chem. 273, 19459-19468
39. Barker, E. L., Moore, K. R., Rakhshan, F., and Blakely, R. D. (1999) J. Neurosci. 19, 4705-4717
40. Rudnick, G., and Nelson, P. J. (1978) Biochemistry 17, 4739-4742
41. Nelson, P. J., and Rudnick, G. (1979) J. Biol. Chem. 254, 10084-10089