IL-2 induces expression and secretion of IFN-γ in murine peritoneal macrophages

Journal of Leukocyte Biology

Volumn 78, Issue 3, 2005, Pages 686-695

  Puddu, Patrizia ^a   Carollo, Maria ^a   Pietraforte, Immacolata ^a   Spadaro, Francesca ^a   Tombesi, Marina ^a   Ramoni, Carlo ^a   Belardelli, Filippo ^a   Gessani, Sandra ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Cytokine secretion; Gene regulation; Mouse

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; MESSENGER RNA; NEUTRALIZING ANTIBODY;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; GENE CONTROL; INNATE IMMUNITY; MOUSE; MOUSE STRAIN; NONHUMAN; PERITONEUM MACROPHAGE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; RECEPTOR BLOCKING; T LYMPHOCYTE;

ANIMALS; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-2; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, NUDE; PHENOTYPE; RECEPTORS, INTERLEUKIN-2; RNA, MESSENGER; SPECIES SPECIFICITY;

MURINAE;

EID: 24744440115     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0105035     Document Type: Article

References (32)

1. Schroder, K., Hertzog, J. P., Ravasi, T., Hume, D. A. (2004) Interferon-γ: an overview of signals, mechanisms and functions. J. Leukoc. Biol. 75, 163-189.
2. Trinchieri, C. (1997) Cytokines acting on or secreted by macrophages during intracellular infection (IL-10, IL-12, IFN-γ). Curr. Opin. Immunol. 9, 17-23.
3. Billiau, A. (1996) Interferon-γ: biology and role in pathogenosis. Adv. Immunol. 62, 61-130.
4. Nathan, C. F., Prendergast, T. J., Wiebe, M. E., Stanley, E. R., Plalzer, E., Remold, H. G., Welte, K., Rubin, B. Y., Murray, H. W. (1984) Activation of human macrophages. Comparison of other cytokines with inteferon-γ. J. Exp. Med. 160, 600-605.
5. Gajewski, T. F., Goldwasser, E., Fitch, F. W. (1988) Anti-proliferative effect of IFN-γ in immune regulation. II. IFN-γ inhibits the proliferation of murine bone marrow cells stimulated with IL-3, IL-4, or granulocyte-macrophage colony-stimulating factor. J. Immunol. 141, 2635-2642.
6. Boehm, U., Klamp, T., Groot, M., Howard, J. C. (1997) Cellular responses to interferon-γ. Annu. Rev. Immunol. 15, 749-795.
7. Gessani, S., Belardelli, F. (1998) IFN-γ expression in macrophages and its possible biological significance. Cytokine Growth Factor Rev. 9, 117-123.
8. Frucht, D. M., Fukao, T., Bogdan, C., Schindler, H., O'Shea, J. J., Koyasu, S. (2001) IFN-γ production by antigen-presenting cells: mechanisms emerge. Trends Immunol. 22, 556-560.
9. Di Marzio, P., Puddu, P., Conti, L., Belardelli, F., Gessani, S. (1994) Interferon γ upregulates its own gene expression in mouse peritoneal macrophages. J. Exp. Med. 179, 1731-1736.
10. Fultz, M. J., Barber, S. A., Dieffenbach, C. W., Vogel, S. N. (1993) Induction of IFN-γ in macrophages by lipopolysaccharide. Int. Immunol. 5, 1383-1392.
11. Puddu, P., Fantuzzi, L., Borghi, P., Varano, B., Rainaldi, G., Guillemard, E., Malorni, W., Nicaise, P., Wolf, S. F., Belardelli, F., Gessani, S. (1997) IL-12 induces IFN-γ expression and secretion in mouse peritoneal macrophages. J. Immunol. 159, 3490-3497.
12. Fantuzzi, L., Puddu, P., Varano, B., Del Cornò, M, Belardelli, F., Gessani, S. (2000) IFN-α and IL-18 exert opposite regulatory effects on the IL-12 receptor expression and IL-12-induced IFN-γ production in mouse macrophages: novel pathways in the regulation of the inflammatory response of macrophages. J. Leukoc. Biol. 68, 707-714.
13. Theze, J., Alzari, P. M., Bertoglio, J. (1996) Interleukin 2 and its receptors: recent advances and new immunological functions. Immunol. Today 17, 481-486.
14. Van Parijs, L., Refaeli, Y., Lord, J. D., Nelson, B. H., Abbas, A. K., Baltimore, D. (1999) Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death. Immunity 11, 281-288.
15. Schimpl, A., Berberich, I., Kneitz, B., Kramer, S., Santner-Nanan, B., Wagner, S., Wolf, M., Huning, T. (2002) IL-2 and autoimmune disease. Cytokine Growth Factor Rev. 13, 369-378.
16. Espinoza-Delgado, I., Bosco, M. C., Musso, T., Gusella, C. L., Longo, D. L., Varesia, L. (1995) Interleukin-2 and human monocyte activation. J. Leukoc. Biol. 57, 13-19.
17. Verstovsek, S., Maccubin, D., Ehrke, M. J., Mihich, E. (1992) Tumoricidal activation of murine resident peritoneal macrophages by interleukin 2 and tumor necrosis factor α. Cancer Res. 52, 3880-3885.
18. Narumi, S., Finke, J. H., Hamilton, T. A. (1990) Interferon γ and interleukin 2 synergize to induce selective monokine expression in murine peritoneal macrophages. J. Biol. Chem. 265, 7036-7041.
19. Belosevic, M., Finbloom, D. S., Mellzer, M. S., Nacy, C. A. (1990) IL-2. A cofactor for induction of activated macrophage resistance to infection. J. Immunol. 145, 831-839.
20. Fukao, T., Koyasu, S. (2000) Expression of functional IL-12 receptors on mature splenic dendritic cells. Eur. J. Immunol. 30, 1453-1457.
21. Granucci, F., Zanoni, I., Feau, S., Ricciardi-Castagnoli, P. (2003) Dendritic cell regulation of immune responses: a new role for interleukin-2 at the intersection of innate and adaptive immunity. EMBO J. 22, 2546-2551.
22. Matsui, K. (1999) Hole of interleukin-2 receptor expression on macrophages from Salmonella-infected mice. FEMS Immunol. Med. Microbiol. 24, 97-103.
23. Belardelli, F., Vignaux, F., Proietti, E., Gresser, I. (1984) Injection of mice with antibody to interferon renders peritoneal macrophages permissive for vesicular stomatitis virus and encephalomyocarditis virus. Proc. Natl. Acad. Sci. USA 81, 602-606.
24. Nemoto, T., Takeshila, T., Ishii, N., Kondo, M., Higuchi, M., Satomi, S., Nakamura, M., Mori, S., Sugamura, K. (1995) Differences in the interleukin-2 (IL-2) receptor system in human and mouse: α chain is required for formation of the functional mouse IL-2 receptor. Eur. J. Immunol. 25, 3001-3005.
25. Munder, M., Mallo, M., Eichmann, K., Modolell, M. (1998) Murine macrophages secrete interferon γ upon combined stimulation with interleukin (IL)-12 and IL-18: a novel pathway of autocrine macrophage activation. J. Exp. Med. 187, 2103-2108.
26. Schindler, H., Lutz, M-B., Rollinghoff, M. (2001) The production of IFN-γ by IL-12/IL-18-activated macrophages requires STAT4 signaling and is inhibited by IL-4. J. Immunol. 166, 3075-3082.
27. Fukao, T., Frucht, D. M., Yap, G., Gadina, M., O'Shea, J. J., Koyasu, S. (2001) Inducible expression of Stat4 in dendritic cells and macrophages and its critical role in innate and adaptive immune responses. J. Immunol. 166, 4446-4455.
28. Suzue, K., Asai, T., Takeuchi, T., Koyasu, S. (2003) In vivo role of IFN-γ produced by antigen-presenting cells in early host defense against intracellular pathogens. Eur. J. Immunol. 33, 2666-2675.
29. Balomenos, D., Rumold, R., Theofilopoulos, A. N. (1998) Interferon-γ is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice. J. Clin. Invent. 101, 364-371.
30. Carvalho-Pinto, C. E., Garcia, M. I., Mellado, M., Rodriguez-Frade, J. M., Martin-Caballero, J., Flores, J., Martinez, A. C., Balomenos, D. (2002) Autocrine production of IFN-γ by macrophages controls their recruitment to kidney and the development of glomerulonephritis in MRL/lpr mice. J. Immunol. 169, 1058-1067.
31. Kuroda, E., Kito, T., Yamashita, U. (2002) Reduced expression of STAT4 and IFN-γ in macrophages from BALB/c mice. J. Immunol. 168, 5477-5482.
32. + NK cells are the source of IFN-γ in IL-12/IL-18-stimulated mouse macrophage populations. Blood 105, 1319-1328.