Novel breast-tumor-associated MUC1-derived peptides: Characterization in D(b-)/- x β2 microglobulin (β2m) null mice transgenic for a chimeric HLA- A2.1/D(b)-β2 microglobulin single chain

International Journal of Cancer

Volumn 85, Issue 3, 2000, Pages 391-397

  Carmon, Lior ^a   El Shami, Khaled M ^a   Paz, Adrian ^a   Pascolo, Steve ^b   Tzehoval, Esther ^a   Tirosh, Boaz ^a   Koren, Romelin ^c   Feldman, Michael ^a   Fridkin, Mati ^a   Lemonnier, François A ^b   Eisenbach, Lea ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b INSTITUT PASTEUR   (France)

^c Golda Campus ^*  (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CARCINOMA; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; IMMUNOGENICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; TRANSGENIC MOUSE;

ANIMALS; ANTIGEN PRESENTATION; BETA 2-MICROGLOBULIN; BREAST NEOPLASMS; CA-15-3 ANTIGEN; CANCER VACCINES; CYTOTOXICITY, IMMUNOLOGIC; EPITOPES, T-LYMPHOCYTE; FEMALE; FLUORESCENCE; GENE EXPRESSION REGULATION, NEOPLASTIC; H-2 ANTIGENS; HLA-A2 ANTIGEN; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; PEPTIDE FRAGMENTS; PEPTIDES; PROTEIN BINDING; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES, CYTOTOXIC; TUMOR CELLS, CULTURED;

EID: 0033986154     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(20000201)85:3<391::AID-IJC16>3.0.CO;2-V     Document Type: Article

References (22)

1. AGRAWAL, B., KRANTZ, M.J., REDDISH, M.A. and LONGENECKER, B.M., Cancer-associated MUC1 mucin inhibits human T-cell proliferation, which is reversible by IL-2. Nature Med., 4, 43-49 (1998).
2. APOSTOLOPOULOS, V., KARANIKAS, V., HAURUM, J.S. and MCKENZIE, I.F., Induction of HLA-A2-restricted CTLs to the mucin 1 human breast cancer antigen. J. Immunol., 159, 5211-5218 (1997).
3. BARND, D.L., LAN, M.S., MEZGAR, R.S. and FINN, O.J., Specific major histocompatibility complex-unrestricted recognition of tumor-associated mucins by human cytotoxic T cells. Proc. nat. Acad. Sci. (Wash.), 86, 7159-7163 (1989).
4. BARRA, C., GOURNIER, H., GARCIA, Z., MARCHE, P.N., JOUVIN-MARCHE, E., BRIAND, P., FILLIPI, P. and LEMONNIER, F.A., Abrogation of H-2-restricted CTL responses and efficient recognition of HLA-A3 molecules in DBA/2 HLA/A24 responder mice. J. Immunol., 150, 3681-3689 (1993).
5. BARUCH, A., HARTMAN, M., ZRIHAN-LICHT, S., GREENSTEIN, S., BURSTEIN, M., KEYDAR, I., WEISS, M., SMORODINSKY, N. and WRESCHNER, D.H., Preferential expression of novel MUC1 tumor antigen isoforms in human epithelial tumors and their tumor potentiating function. Int. J. Cancer, 71, 741-749 (1997).
6. DOMENECH, N., HENDERSON, R.A. and FINN, O.J., Identification of an HLA-A11-restricted epitope from the tandem repeat domain of the epithelial tumor antigen mucin. J. Immunol., 155, 4766-4774 (1995).
7. FISK, B., BLEVINS, T.L., TYLOR-WHARTON, J. and IONNIDES, C.G., Identification of an immunodominant peptide of HER2/neu protooncogene recognized by ovarian tumor specific cytotoxic T-lymphocyte lines. J. exp. Med., 181, 2109-2117 (1995).
8. FUNG, P.Y. and LONGENECKER, B.M., Specific immunosuppressive activity of epiglycanin, a mucin-like glycoprotein secreted by a murine mammary adenocarcinoma (TA3-HA). Cancer Res., 51, 1170-1176 (1991).
9. GRAHAM, R.A., BURCHELL, J.M. and TAYLOR-PAPADIMITRIOU, J., The polymorphic epithelial mucin: potential as an immunogen for a cancer vaccine. Cancer Immunol. Immunother., 42, 71-80 (1996).
10. HO, S.B., NIEHANS, G.A., LYFTOGT, C., YAN, P.S., CHERWITZ, D.L., GUM, E.T., DAHIYA, R. and KIM, Y.S., Heterogeneity of mucin gene expression in normal and neoplastic tissues. Cancer Res., 53, 641-651 (1993).
11. PARKER, K.C., BEDNAREK, M.A. and COLIGAN, J.E., Scheme for ranking potential HLA-A2 binding peptides based on independent binding of individual peptide side-chains. J. Immunol., 152, 163-175 (1994).
12. b-β2m double knockout mice. J. exp. Med., 185, 2043-2051 (1997).
13. RAMMENSEE, H.G., FALK, K. and ROTZSCHKE, O., Peptide naturally presented by MHC class I molecules. Ann. Rev. Immunol., 11, 213-244 (1993).
14. RAS, E., VAN DER BURG, S.H., ZEGVELD, S.T., BRANDT, R.M., KUPPEN, P.J., OFFRINGA, R., WARNARR, S.O., VAN DE VELDE, C.J. and MELIEF, C.J., Identification of potential HLA-A *0201 restricted CTL epitopes derived from the epithelial cell adhesion molecule (Ep-CAM) and the carcinoembryonic antigen (CEA). Hum. Immunol., 53, 81-89 (1997).
15. SETTE, A. and 16 OTHERS, The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes. J. Immunol., 153, 5586-5592 (1994).
16. SHIRAI, M., ARICHI, T., NISHIOKA, M., NOMURA, T., IKEDA, K., KAWANISHI, K., ENGELHARD, V.H., FEINSTONE, S.M. and BERZOFSKY, J.A., CTL response of HLA-A2.1 transgenic mice specific for hepatitis C viral peptides predicts epitope for CTL of human carrying HLA-A2.1. J. Immunol., 154, 2733-2742 (1995).
17. SPICER, A.P., ROWSE, G.J., LINDER, T.K. and GENDLER, S.J., Delayed mammary tumor progression in MUC1 null mice. J. biol. Chem., 270, 30093-30101 (1995)
18. VAN DE WIEL-VAN KEMENADE, E., LIGTENBERG, M.J., DE BOER, A.J., BUUS, F., VOS, H.L., MELIEF, C.J., HILKENS, J. and FIGDOR, C.G., Episialin (MUC1) inhibits cytotoxic lymphocyte-target cell interaction. J. Immunol., 151, 767-776 (1993).
19. VITIELLO, A., SETTE, A., YUAN, L., FARNESS, P., SOUTHWOOD, S., SIDNEY, J., CHESNUT, R.W., GREY, H.M. and LIVINGSTON, B., Comparison of cytotoxic T lymphocyte responses induced by peptide or DNA immunization: implication on immunogenicity and immunodominance. Europ. J. Immunol., 27, 671-678 (1997).
20. WENTWORTH, P.A., VITIELLO, A., SIDNEY, J., KEOGH, E., CHESNUT, R.W., GREY, H. and SETTE, A., Differences and similarities in the A2.1-restricted cytotoxic T cell repertoire in human and human leukocyte antigen-transgenic mice. Europ. J. Immunol., 26, 97-101 (1996).
21. YOUNG, R.K., CAILLEAU, R.M., MACKAY, B. and REEVES, W.J., JR., Establishment of epithelial cell line MDA-MB-157 from metastatic pleural effusion of human breast carcinoma. In Vitro, 9, 239-245 (1974).
22. ZHANG, L., ZHOU, W., VELCULESCU, V.E., KERN, S.E., HRUBAN, R.H., HAMILTON, S.R., VOGELSTEIN, B. and KINZLER, K.W., Gene expression profiles in normal and cancer cells. Science, 276, 1268-1272 (1997).