MUC1 epithelial mucin (CD227) is expressed by activated dendritic cells

Journal of Leukocyte Biology

Volumn 72, Issue 4, 2002, Pages 692-701

  Wykes, M ^a   MacDonald, K P A ^a   Tran, M ^a   Quin, R J ^a   Xing, P X ^b   Gendler, S J ^c   Hart, D N J ^a   McGuckin, Michael A ^a  

^a MATER MEDICAL RESEARCH INSTITUTE   (Australia)

^b AUSTIN RESEARCH INSTITUTE   (Australia)

^c MAYO CLINIC   (United States)

Author keywords

Activation; Glycoprotein; Sialomucin; T cell

Indexed keywords

MUCIN 1;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; DENDRITIC CELL; EPITHELIUM; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SPLEEN; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, CD11C; B-LYMPHOCYTES; CA-15-3 ANTIGEN; CELLS, CULTURED; CYTOPLASM; DENDRITIC CELLS; HUMANS; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; SPLEEN; T-LYMPHOCYTES;

ANIMALIA; MURINAE;

EID: 0036826802     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Gendler, S. J. (2001) MUC1, the renaissance molecule. J. Mammary Gland Biol. Neoplasia 6, 339-353.
2. Williams, S. J., Wreschner, D. H., Tran, M., Eyre, H. J., Sutherland, G. R., McGuckin, M. A. (2001) MUC13 - a novel human cell surface mucin expressed by epithelial and hemopoietic cells. J. Biol. Chem. 276, 18327-18336.
3. Verfaille, C. M. (1998) Adhesion receptors as regulators of the haemopoietic process. Blood 92, 2609-2612.
4. Zrihan-Licht, S., Baruch, A., Elroy-Stein, O., Keydar, I., Wreschner, D. H. (1994) Tyrosine phosphorylation of the MUC1 breast cancer membrane proteins cytokine receptor-like molecules. FEBS Lett. 356, 130-136.
5. Pandey, P., Kharbanda, S., Kufe, D. (1995) Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein. Cancer Res. 55, 4000-4003.
6. Agrawal, B., Krantz, M. J., Parker, J., Longenecker, B. M. (1998) Expression of MUC1 mucin on activated human T cells: implications for a role of MUC1 in normal immune regulation. Cancer Res. 58, 4079-4081.
7. Treon, S. P., Mollick, J. A., Urashima, M., Teoh, G., Chauhan, D., Ogata, A., Raje, N., Hilgers, J. H. M., Nadler, L., Belch, A. R., Pilarski, L. M., Anderson, K. C. (1999) Muc-1 core protein is expressed on multiple myeloma cells and is induced by dexamethasone. Blood 93, 1287-1298.
8. Brugger, W., Buhring, H. J., Grunebach, F., Vogel, W., Kaul, S., Multer, R., Brummendorf, T. H., Ziegler, B. L., Rappold, I., Brossart, P., Scheding, S., Kanz, L. (1999) Expression of MUC-1 epitopes on normal bone marrow: implications for the detection of micrometastatic tumor cells. J. Clin. Oncol. 17, 1535-1544.
9. Xing, P. X., Tjandra, J. J., Stacker, S. A., Teh, J. G., Thompson, C. H., McLaughlin, P. J., McKenzie, I. F. C. (1989) Monoclonal antibodies reactive with mucin expressed in breast cancer. Immunol. Cell Biol. 67, 183-195.
10. McGuckin, M. A. (2001) CD227 (MUC1) - summary and workshop report. In Leucocyte Typing VII (D. Mason, ed.), Oxford, UK, Oxford University Press, 54-56.
11. Agrawal, B., Gendler, S. J., Longenecker, B. M. (1998) The biological role of mucins in cellular interactions and immune regulation: prospects for cancer immunotherapy. Mol. Med. Today 4, 397-403.
12. Finn, O. J., Jerome, K. R., Henderson, R. A., Pecher, G., Domenech, N., Barrattboyes, S. M. (1995) MUC-1 epithelial tumor mucin-based immunity and cancer vaccines. Immunol. Rev. 145, 61-89.
13. Miles, D. W., Taylor-Papadimitriou, J. (1999) Therapeutic aspects of polymorphic epithelial mucin in adenocarcinoma. Pharmacol. Therapeut. 82, 97-106.
14. Xing, P. X., Lees, C., Lodding, J., Prenzoska, J., Poulos, G., Sandrin, M., Gendler, S., McKenzie, I. F. C. (1998) Mouse mucin 1 (muc1) defined by monoclonal antibodies. Int. J. Cancer 76, 875-883.
15. Harlow, E., Lane, D. (1998) Antibodies: A Laboratory Manual, Cold Spring Harbor, NY, Cold Spring Harbor Laboratory pp. 340-357.
16. Wykes, M., MacPherson, G. (2000) Dendritic cell-B-cell interaction: dendritic cells provide B cells with CD40-independent proliferation signals and CD40-dependent survival signals. Immunology 100, 1-3.
17. Wykes, M., Pombo, A., Jenkins, C., MacPherson, G. G. (1998) Dendritic cells interact directly with naive B lymphocytes to transfer antigen and initiate class switching in a primary T-dependent response. J. Immunol. 161, 1313-1319.
18. Wykes, M., Poudrier, J., Lindstedt, R., Gray, D. (1998) Regulation of cytoplasmic, surface and soluble forms of CD40 ligand in mouse B cells. Eur. J. Immunol. 28, 548-559.
19. Quin, R. J., McGuckin, M. A. (2000) Phosphorylation of MUC1 correlates with changes in cell-cell adhesion. Int. J. Cancer 87, 499-506.
20. Walsh, M. D., Luckie, S. M., Cummings, M. C., Antalis, T. M., McGuckin, M. A. (1999) Heterogeneity of MUC1 expression by human breast cancer cell lines in vivo and in vitro. Breast Cancer Res. Treat. 58, 255-266.
21. Fearnley, D. B., McLellan, A. D., Mannering, S. I., Hock, B. D., Hart, D. N. (1997) Isolation of human blood dendritic cells using the CMRF-44 monoclonal antibody: implications for studies on antigen-presenting cell function and immunotherapy. Blood 89, 3708-3716.
22. Kamath, A. T., Pooley, J., O'Keeffe, M. A., Vremec, D., Zhan, Y., Lew, A. M., D'Amico, A., Wu, L., Tough, D. F., Shortman, K. (2001) The development, maturation, and turnover rate of mouse spleen dendritic cell populations. J. Immunol. 165, 6762-6770.
23. Pierre, P., Turley, S. J., Gatti, E., Hull, M., Meltzer, J., Mirza, A., Inaba, K., Steinman, R. M., Mellman, I. (1997) Developmental regulation of MHC class II transport in mouse dendritic cells. Nature 388, 787-792.
24. Nath, D., Hartnell, A., Happerfield, L., Miles, D. W., Burchell, J., Taylor-Papadimitriou, J., Crocker, P. R. (1999) Macrophage-tumour cell interactions: identification of muc1 on breast cancer cells as a potential counter-receptor for the macrophage-restricted receptor, sialoadhesin. Immunology 98, 213-219.
25. Chang, J. F., Zhao, H. L., Phillips, J., Greenburg, G. (2000) The epithelial mucin, MUC1, is expressed on resting T lymphocytes and can function as a negative regulator of T cell activation. Cell. Immunol. 201, 83-88.
26. Smorodinsky, N., Weiss, M., Hartmann, M. L., Baruch, A., Harness, E., Yaakobovitz, M., Keydar, I., Wreschner, D. H. (1996) Detection of a secreted MUC1/SEC protein by MUC1 isoform specific monoclonal antibodies. Biochem. Biophys. Res. Commun. 228, 115-121.
27. Corinti, S., Fanales-Belasio, E., Albanesi, C., Cavani, A., Angelisova, P., Girolomoni, G. (1999) Cross-linking of membrane CD43 mediates dendritic cell maturation. J. Immunol. 162, 6331-6336.
28. Ostberg, J. R., Barth, R. K., Frelinger, J. G. (1998) The Roman God Janus: a paradigm for the function of CD43. Immunol. Today 19, 546-550.
29. Williams, S. J., McGuckin, M. A., Gotley, D. C., Eyre, H. J., Sutherland, G. R., Antalis, T. M. (1999) Two novel mucin genes downregulated in colorectal cancer identified by differential display. Cancer Res. 59, 4083-4089.
30. Moniaux, N., Nollet, S., Porchet, N., Degand, P., Laine, A., Aubert, J. P. (1999) Complete sequence of the human mucin MUC4: a putative cell membrane-associated mucin. Biochem. J. 338, 325-333.
31. Williams, S. J., Munster, D. J., Quin, R. J., Gotley, D. C., McGuckin, M. A. (1999) The MUC3 gene encodes a transmembrane mucin and is alternatively spliced. Biochem. Biophys. Res. Commun. 261, 83-89.
32. Altschuler, Y., Kinlough, C. L., Poland, P. A., Bruns, J. B., Apodaca, G., Weisz, O. A., Hughey, R. P. (2000) Clathrin-mediated endocytosis of MUC1 is modulated by its glycosylation state. Mol. Biol. Cell 11, 819-831.
33. Baruch, A., Hartmann, M. L., Yoeli, M., Adereth, Y., Greenstein, S., Stadler, Y., Skornik, Y., Zaretsky, J., Smorodinsky, N. I., Keydar, I., Wreschner, D. H. (1999) The breast cancer-associated MUC1 gene generates both a receptor and its cognate binding protein. Cancer Res. 59, 1552-1561.
34. Seveau, S., Keller, H., Maxfield, F. R., Piller, F., Halbwachs-Mecarelli, L. (2000) Neutrophil polarity and locomotion are associated with surface redistribution of leukosialin (CD43), an antiadhesive membrane molecule. Blood 95, 2462-2470.
35. Manjunath, N., Correa, M., Ardman, M., Ardman, B. (1995) Negative regulation of T-cell adhesion and activation by CD43. Nature 377, 535-538.
36. Carlow, D. A., Corbel, S. Y., Ziltener, H. J. (2001) Absence of CD43 fails to alter T cell development and responsiveness. J. Immunol. 166, 256-261.
37. Walker, J., Green, J. M. (1999) Structural requirements for CD43 function. J. Immunol. 162, 4109-4114.
38. Santana, M. A., Pedraza-Alva, G., Olivares-Zavaleta, N., Madrid-Marina, V., Horejsi, V., Burakoff, S. J., Rosenstein, Y. (2000) CD43-mediated signals induce DNA binding activity of AP-1, NF-AT, and NFkappa B transcription factors in human T lymphocytes. J. Biol. Chem. 275, 31460-31468.
39. Pedraza-Alva, G., Merida, L. B., Burakoff, S. J., Rosenstein, Y. (1998) T cell activation through the CD43 molecule leads to Vav tyrosine phosphorylation and mitogen-activated protein kinase pathway activation. J. Biol. Chem. 273, 14218-14224.
40. Wesseling, J., Vandervalk, S. W., Vos, H. L., Sonnenberg, A., Hilkens, J. (1990) Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components. J. Cell Biol. 129, 255-265.
41. Wesseling, J., van der Valk, S. W., Hilkens, J. (1996) A mechanism for inhibition of E-cadherin-mediated cell-cell adhesion by the membrane-associated mucin episialin/MUC1. Mol. Biol. Cell 7, 565-577.
42. Parry, G., Beck, J. C., Moss, L., Bartley, J., Ojakian, G. K. (1990) Determination of apical membrane polarity in mammary epithelial cell cultures: the role of cell-cell, cell-substratum, and membrane-cytoskeleton interactions. Exp. Cell Res. 188, 302-311.
43. Bennett Jr., R., Jarvela, T., Engelhardt, P., Kostamovaara, L., Sparks, P., Carpen, O., Turunen, O., Vaheri, A. (2001) Mucin MUC1 is seen in cell surface protrusions together with ezrin in immunoelectron tomography and is concentrated at tips of filopodial protrusions in MCF-7 breast carcinoma cells. J. Histochem. Cytochem. 49, 67-78.
44. Serrador, J. M., Nieto, M., Alonso-Lebrero, J. L., del Pozo, M. A., Calvo, J., Furthmayr, H., Schwartz-Albiez, R., Lozano, F., Gonzalez-Amaro, R., Sanchez-Mateos, P., Sanchez-Madrid, F. (1998) CD43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell-cell contacts. Blood 91, 4632-4644.
45. Karanikas, V., Hwang, L. A., Pearson, J., Ong, C. S., Apostolopoulos, V., Vaughan, H., Xing, P. X., Jamieson, G., Pietersz, G., Tait, B., Broadbent, R., Thynne, G., McKenzie, I. F. C. (1997) Antibody and T cell responses of patients with adenocarcinoma immunized with mannan-MUC1 fusion protein. J. Clin. Investig. 100, 2783-2792.
46. Goydos, J. S., Elder, E., Whiteside, T. L., Finn, O. J., Lotze, M. T. (1996) A phase I trial of a synthetic mucin peptide vaccine. Induction of specific immune reactivity in patients with adenocarcinoma. J. Surg. Res. 63, 298-304.
47. Reddish, M. A., MacLean, G. D., Koganty, R. R., Kan-Mitchell, J., Jones, V., Mitchell, M. S., Longenecker, B. M. (1998) Anti-MUC1 class I restricted CTLs in metastatic breast cancer patients immunized with a synthetic MUC1 peptide. Int. J. Cancer 76, 817-823.
48. Brossart, P., Wirths, S., Stuhler, G., Reichardt, V. L., Kanz, L., Brugger, W. (2000) Induction of cytotoxic T-lymphocyte responses in vivo after vaccinations with peptide-pulsed dendritic cells. Blood 96, 3102-3108.
49. Musselli, C., Ragupathi, G., Gilewski, T., Panageas, K. S., Spinat, Y., Livingston, P. O. (2002) Reevaluation of the cellular immune response in breast cancer patients vaccinated with MUC1. Int. J. Cancer 97, 660-667.
50. Scholl, S. M., Balloul, J. M., Le Goc, G., Bizouarne, N., Schatz, C., Kieny, M. P., von Mensdorff-Pouilly, S., Vincent-Salomon, A., Deneux, L., Tartour, E., Fridman, W., Pouillart, P., Acres, B. (2000) Recombinant vaccinia virus encoding human MUC1 and IL2 as immunotherapy in patients with breast cancer. J. Immunother. 23, 570-580.
51. Gong, J., Chen, D., Kashiwaba, M., Li, Y., Chen, L., Takeuchi, H., Qu, H., Rowse, G. J., Gendler, S. J., Kufe, D. (1998) Reversal of tolerance to human MUC1 antigen in MUC1 transgenic mice immunized with fusions of dendritic and carcinoma cells. Proc. Natl. Acad. Sci. USA 95, 6279-6283.