Intramuscular immunisation with MUC1 cDNA can protect C57 mice challenged with MUC1-expressing syngeneic mouse tumour cells

International Journal of Cancer

Volumn 65, Issue 5, 1996, Pages 664-670

  Graham, Rosalind A ^a   Burchell, Joy M ^a   Beverley, Peter ^a   Taylor Papadimitriou, Joyce ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; MUCIN LIKE CARCINOMA ASSOCIATED ANTIGEN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; IMMUNE RESPONSE; IMMUNIZATION; INTRAMUSCULAR DRUG ADMINISTRATION; MOUSE; PRIORITY JOURNAL; TUMOR REJECTION;

ANIMALS; ANTIBODY FORMATION; CA-15-3 ANTIGEN; FEMALE; IMMUNIZATION; INJECTIONS, INTRAMUSCULAR; MICE; MICE, INBRED C57BL; NEOPLASMS, EXPERIMENTAL; RNA, MESSENGER; SURVIVAL ANALYSIS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0029916313     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19960301)65:5<664::AID-IJC17>3.0.CO;2-7     Document Type: Article

References (28)

1. ACRES, R.B., HAREUVENI, M., BALLOUL, J.-M. and KIENY, M.-P., Vaccinia virus MUC1 immunisation of mice: immune response and protection against the growth of murine tumours bearing the MUC1 antigen. J. Immunother., 14, 136-143 (1993).
2. BALLOUL, J.-M., ACRES, R.B., GEIST, M., DOTT, K., STEFFANI, L., SCHMIDTT, D., DRILLIEN, R., SPHENER, D., MCKENZIE, I., XING, P.-X. and KIENY, M.P., Recombinant MUC1 vaccinia virus: a potential vector for immunotherapy of breast cancer. Cell mol. Biol., 40, 49-59 (1994).
3. BARND, D.L., LAN, M.S., METZGAR, R.S. and FINN, O.J., Specific, major histocompatability complex-unrestricted recognition of tumour-associated mucins by human cytotoxic T cells. Proc. nat. Acad. Sci. (Wash.), 86, 7159-7164 (1989).
4. BURCHELL, J., GENDLER, S.J., TAYLOR-PAPADIMITRIOU, J., GIRLING, A., LEWIS, A., MILLIS, R. and LAMPORT, D., Development and characterisation of breast cancer reactive monoclonal antibodies directed to the core protein of the human milk mucin. Cancer Res., 47, 5476-5482 (1987).
5. BURCHELL, J., TAYLOR-PAPADIMITRIOU, J., BOSHELL, M., GENDLER, S.J. and DUHIG, T., A short sequence within the amino acid tandem repeat of a cancer associated mucin, contains immunodominant epitopes. Int. J. Cancer, 44, 691-696 (1989).
6. CONRY, R.M., LOBUGLIO, A.F., LOECHEL, F., MOORE, S.E., SUMEREL, L.A., BARLOW, D.L. and CURIEL, D.T., A carcinoembryonic antigen polynucleotide vaccine has in vivo antitumour activity. Gene Therapy, 2, 59-65 (1995).
7. DOMENECH, N. and FINN, O.J., In-vitro studies of MHC-restricted recognition of a peptide from the MUC1 tandem repeat domain by CTL. FASEB J., 9, A1023 (1995).
8. FINN, O.J., Antigen specific, MHC-unrestricted T cells. Biotherapy, 4, 239-249 (1992).
9. GENDLER, S.J., LANCASTER, C.A., TAYLOR-PAPADIMITRIOU, J., DUHIG, T., PEAT. N., BURCHELL, J., PEMBERTON, L., LALANI, E.-N. and WILSON, D., Molecular cloning and expression of the human tumour-associated polymorphic epithelial mucin. J. biol. Chem., 265, 15286-15293 (1990).
10. GRAHAM, R.A., STEWART, L.S , PEAT, N.P., BEVERLEY, P. and TAYLOR-PAPADIMITRIOU, J., MUC1-based immunogens for tumour therapy: development of murine model systems. Tumour Targeting, 1, 211-221 (1995).
11. GUNNING, P., LEAVITT, J., MUSCAT, G., NG, S.Y. and KEDES, L., A human beta-actin expression vector system directs high level accumulation of antisense transcripts. Proc. nat. Acad. Sci. (Wash.), 84, 4831-4835 (1987).
12. HAREVEUNI, M., GAUTIER, C., KIENY, M.-P., WRESCHNER, D., CHAMBON, P. and LATHE, R., Vaccination against tumour cells expressing breast cancer epithelial tumour antigen. Proc. nat. Acad. Sci. (Wash.), 87, 9498-9502 (1990).
13. HARLOW, E. and LANE, D., Antibodies. A laboratory manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor. NY (1988).
14. IOANNIDES, C.G., FISK, B., JEROME, K.R., TATSURO, I., TAYLOR WHARTON, J. and FINN, O.J., Cytotoxic T cells from ovarian malignant tumours can recognise polymorphic epithelial mucin core peptides. J. Immunol., 7, 3693-3703 (1993).
15. JEROME, K.R., BARND, D.L., BENDT, K.M., BOYER, C.M., TAYLOR-PAPADIMITRIOU, J., MCKENZIE, I.F.C., BAST, R.C. and FINN, O.J., Cytotoxic T-lymphocytes derived from patients with breast adenocarcinoma recognize an epitope present on the protein core of a mucin molecule preferentially expressed by malignant cells. Cancer Res., 51, 2908-2916 (1989).
16. JIOA, S.S., WILLIAMS, P., BERG, R.K., HODGEMAN, B.A., LIU, L.J., REPETTO, G. and WOLFF, J.A., Direct gene-transfer in nonhuman primate myofibres in vivo. Hum. Gene Ther., 3, 21-33 (1992).
17. KOTERA, Y., FONTENOT, J.D., PECHER, G., METZGAR, R.S. and FINN, O.J., Humoral immunity against a tandem repeat epitope of human mucin MUC1 in sera from breast. pancreatic and colon cancer patients. Cancer Res., 54, 2856-2860 (1994).
18. LONGENECKER, B.M., REDDISH, M., KOGANTY, R. and MACLEAN, G.D., Immune response of mice and human breast cancer patients following immunisation with synthetic sialyl-Tn conjugated to KLH plus Detox adjuvant. Ann. N.Y. Acad. Sci., 690, 276-291 (1993).
19. MESSINA, J.P., GILKESON, G.S. and PISETSKY, D.S., Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA. J Immunol., 147, 1759-1764 (1991).
20. PEAT, N., GENDLER, S.J., LALANI, E.-N., DUHIG, T. and TAYLOR-PAPADIMITRIOU, J., Tissue specific expression of a human polymorphic epithelial mucin (MUC1) in transgenic mice. Cancer Res., 52, 1954-1960 (1992).
21. RAZ. E., CARSON, D.A., PARKER, S.E., PARR, T.B., ABAI, A.M., AICHINGER, G., GROMKOWSKI, S.H., SINGH, M., LEW, D., YANKAUCKAS, M.A., BAIRD, S.M. and RHODES, G.H., Intradermal gene immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses. Proc. nat. Acad. Sci. (Wash.), 91, 9519-9523 (1994).
22. ROBINSON, H.L., HUNT, L.A. and WEBSTER, R.G., Protection against a lethal influenza virus challenge by immunisation with a haemagglutinin-expressing plasmid DNA. Vaccine, 11, 957-960 (1993).
23. RUGHETTI, A., TURCHI, V., GHETTI, C.A., SCAMBIA, G., PANICI, P.B., RONCUCCI, G., MANCUSO, S., FRATI, L. and NUTI, M., Human B-cell immune response to the polymorphic epithelial mucin. Cancer Res., 53, 2457-2459 (1993).
24. SAMBROOK, J., FRITSCH, E.F. and MANIATIS, T., Molecular cloning. A laboratory manual (2nd ed.), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY (1989).
25. ULMER, J.B., DECK, R.R., DEWITT, C.M., FRIEDMAN, A., DONNELLY, J.J. and LIU, M.A., Protective immunity by intramuscular injection of low doses of influenza virus DNA vaccines. Vaccine, 12, 1541-1544 (1994).
26. ULMER, J.B. and 16 OTHERS, Heterologous protection against influenza by injection of DNA encoding a viral protein. Science, 259, 1745-1749 (1993).
27. WOLFF, J.A., LUDTKE, J.J., ACSADI, G., WILLIAMS, P. and JANI, A., Long-term persistence of plasmid DNA and foreign gene expression in mouse muscle. Hum. mol. Genet., 1, 363-369 (1992).
28. WOLFF, J.A., MALONE, R.W., WILLIAMS, P., CHONG, W., ACSADIA, G., JANI, A. and FELGNER, P.L., Direct gene transfer into mouse muscle in vivo. Science, 247, 1465-1468 (1990).