Cancer dose-response assessment for acrylonitrile based upon rodent brain tumor incidence: Use of epidemiologic, mechanistic, and pharmacokinetic support for nonlinearity

Regulatory Toxicology and Pharmacology

Volumn 43, Issue 1, 2005, Pages 85-103

  Kirman, C R ^a   Gargas, M L ^b   Marsh, G M ^c   Strother, D E ^d   Klaunig, J E ^e   Collins, J J ^f   Deskin, R ^g  

^a Sapphire Group Inc   (United States)

^b Sapphire Group   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

^d School of Medicine ^*  (United States)

^e INDIANA UNIVERSITY   (United States)

^f DOW CHEMICAL COMPANY   (United States)

^g CYTEC INDUSTRIES INC   (United States)

Author keywords

Acrylonitrile; Cancer dose response assessment; Epidemiology; Mode of action; PBPK modeling; Species differences

Indexed keywords

ACRYLONITRILE; CYANIDE; OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; BIOASSAY; BRAIN CANCER; BRAIN TUMOR; CARCINOGENESIS; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; EXPOSURE; GENOTOXICITY; HUMAN; INCIDENCE; LUNG CANCER; MEDICAL ASSESSMENT; METABOLITE; MORTALITY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; REVIEW; RISK ASSESSMENT; RODENT; TOXICITY;

ANIMALIA; RODENTIA;

EID: 24644449690     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2005.06.007     Document Type: Article

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