Biological markers of acute acrylonitrile intoxication in rats as a function of dose and time

Fundamental and Applied Toxicology

Volumn 36, Issue 2, 1997, Pages 141-148

  Benz, Frederick W ^a   Nerland, Donald E ^a   Corbett, Donna ^a   Li, Junyu ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACRYLONITRILE; BIOLOGICAL MARKER; CYANIDE; GLUTATHIONE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD; BLOOD ANALYSIS; BRAIN; CONTROLLED STUDY; COVALENT BOND; DOSE TIME EFFECT RELATION; INTOXICATION; KIDNEY; LIVER; MALE; NONHUMAN; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 26844530211     PISSN: 02720590     EISSN: None     Source Type: Journal    
DOI: 10.1006/faat.1997.2294     Document Type: Article

References (42)

1. Abreu M. E., Ahmed A. E. Metabolism of acrylonitrile to cyanide:In vitro. Drug Metab. Dispos. 8:1980;376-379.
2. 1414. J. Appl. Toxicol. 3:1983;39-47.
3. Ahmed A. E., Patel K. Acrylonitrile:In vivo. Drug Metab. Dispos. 9:1981;219-222.
4. Ballantyne B. Toxicology of cyanides. Clinical and Experimental Toxicology of Cyanide. 1987;IOP Publishers, Bristol. p. 41-126.
5. Baselt R. C. Cyanide. Analytical Procedures for Therapeutic Drug Monitoring and Emergency Toxicology. 1988;PSG Publ. Co. Littleton. p. 100-102.
6. Benz F. W., Nerland D. E., Pierce W. M., Babiuk C. Acute acrylonitrile toxicity: Studies on the mechanism of the antidotal effect ofDLN. Toxicol. Appl. Pharmacol. 102:1990;142-150.
7. Brieger H., Reiders F., Hodes W. A. Acrylonitrile: spectrophotometric determination, acute toxicity, and mechanism of action. Arch. Ind. Hyg. Occup. Med. 6:1952;128-140.
8. Dudley H. C., Neal P. A. Toxicology of acrylonitrile (vinyl cyanide). I. A study of the acute toxicity. J. Ind. Hyg. Tox. 24:1942;27-36.
9. Ellman G. L. Tissue sulfhydryl groups. Arch. Biochem. Biophys. 82:1959;70-77.
10. 1313. Chem. Res. Toxicol. 4:1991a;678-687.
11. Fennell T. R., MacNeela J. P., Turner M. J., Swenberg J. A. Haemoglobin adduct formation by acrylonitrile in rats and mice. Farmer P. B., Garner R. C., Wright A, S., Steel G. T. Human Carcinogen Exposure. 1991b;241-246 IRL Press, Oxford.
12. Friedman M., Cavins J. F., Wall J. S. Relative nucleophilic reactivities of amino groups and mercaptide ions in addition reactions with alpha, beta-unsaturated compounds. J. Am. Chem. Soc. 87:1965;3672-3682.
13. Gargas M. L., Andersen M. E., Teo S. K., Batra R., Fennell T. R., Kedderis G. L. A physiologically based dosimetry description of acrylonitrile and cyanoethylene oxide in the rat. Toxicol. Appl. Pharmacol. 134:1995;185-194.
14. Ghanayem B. I., Boor P. J., Ahmed A. E. Acrylonitrile-induced gastric mucosal necrosis: Role of gastric glutathione. J. Pharmacol. Exp. Ther. 232:1985;570-577.
15. Graham J. D. P. Hydoxycobalamin as an antidote to acrylonitrile. Toxicol. Appl. Pharmacol. 7:1965;367-372.
16. Gut I., Kopecky J., Nerudova J. Relationship between acrylonitrile biotransformation, pharmacokinetics and acute toxicity: A short review. G. Ital. Med. Lav. 3:1981;131-136.
17. Gut I., Nerudova J., Frantik E., Mirejovska E., Holusa R. Acrylonitrile inhalation in rats. I. Effect on intermediary metabolism. J. Hyg. Epidemiol. Microbiol. Immunol. 28:1984;369-376.
18. Gut I., Nerudova J., Kopecky J., Holecek V. Acrylonitrile biotransformation in rats, mice, and Chinese hamsters as influenced by the route of administration and by phenobarbital, SKF 525-A, cysteine, dimercaprol, or thiosulfate. Arch. Toxicol. 33:1975;151-161.
19. Hashimoto K., Kanai R. Studies on the toxicology of acrylonitrile: Metabolism, mode of action and therapy. Ind. Health. 3:1965;30-40.
20. Hashimoto K., Kanai R. Effect of acrylonitrile on sulphydryls and pyruvate metabolism in tissues. Biochem. Pharmacol. 21:1972;635-640.
21. Jaeger R. J., Conolly R. B., Murphy S. D. Diurnal variation of hepatic glutathione concentration and its correlation with 1,1-dichloroethylene inhalation toxicity in rats. Res. Commun. Chem. Pathol. Pharmacol. 6:1973;465-471.
22. Johannsen F. R., Levinskas G. J. Relationships between toxicity and structure of aliphatic nitriles. Fundam. Appl. Toxicol. 7:1986;690-697.
23. Kedderis G. L., Batra R., Turner M. J. Jr. Conjugation of acrylonitrile and 2-cyanoethylene oxide with hepatic glutathione. Toxicol. Appl. Pharmacol. 135:1995;9-17.
24. Kedderis G. L., Sumner S. C., Held S. D., Batra R., Turner M. J. Jr., Roberts A. E., Fennell T. R. Dose-dependent urinary excretion of acrylonitrile metabolites by rats and mice. Toxicol. Appl. Pharmacol. 120:1993;288-297.
25. Kirschner E. M. Chem. Eng. News. April 8:1996;16-22.
26. Kleinman W. A., Richie J. P. Jr. Determination of thiols and disulfides using high-performance liquid chromatography with electrochemical detection. J. Chromatogr. B. 672:1995;73-80.
27. Knobloch K., Szendzikowski S., Czajkowska T., Krysiak B. [Acute and subacute toxicity of acrylonitrile]. Med. Pracy. 22:1971;257-269.
28. Lorz H. [Percutaneous poisoning with acyrlonitrile]. Deutsche Med. Wchnschr. 75:1950;1087-1088.
29. Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
30. Lundquist P., Rosling H., Sorbo B. Determination of cyanide in whole blood, erythrocytes, and plasma. Clin. Chem. 31:1985;591-595.
31. Maltoni C., Ciliberti A., Cotti G., Perino G. Experimental Research on Acrylonitrile Carcinogenesis. 1987;Princeton Sci. Pub. Princeton.
32. McOmie W. A. Comparative toxicity of methacrylonitrile and acrylonitrile. J. Ind. Hyg. Tox. 31:1949;113-116.
33. Hall A. H., Rumack B. H. TOMES (R) System. (1996);MICROMEDEX, Inc. Englewood.
34. Nerudova J., Gut I., Savolainen H. Consequences of acrylonitrile metabolism in rat hepatocytes: Effects on lipid peroxidation and viability of the cells. Environ. Res. 46:1988;133-141.
35. Paulet G., Desnos J. Acrylonitrile: Toxicity, mechanism of action, therapy. Arch. Intern. Pharmacodyn. 131:1961;54-83.
36. Richie J. P. Jr., Lang C. A., Chen T. S. Acetaminophen-induced depletion of glutathione and cysteine in the aging mouse kidney. Biochem. Pharmacol. 44:1992;129-135.
37. Roberts A. E., Lacy S. A., Pilon D., Turner M. J. Jr., Rickert D. E. Metabolism of acrylonitrile to 2-cyanoethylene oxide in F-344 rat liver microsomes, lung microsomes, and lung cells. Drug Metab. Dispos. 17:1989;481-486.
38. Szabo S., Bailey K. A., Boor P. J., Jaeger R. J. Acrylonitrile and tissue glutathione: Differential effect of acute and chronic interactions. Biochem. Biophys. Res. Commun. 79:1977;32-37.
39. Szabo S., Huttner I., Kovacs K., Horvath E., Szabo D., Horner H. C. Pathogenesis of experimental adrenal hemorrhagic necrosis (apoplexy): Ultrastructural, biochemical, neuropharmacologic, and blood coagulation studies with acrylonitrile in the rat. Lab. Invest. 42:1980;533-546.
40. Vainio H., Makinen A. Styrene and acrylonitrile induced depression of hepatic nonprotein sulfhydryl content in various rodent species. Res. Commun. Chem. Pathol. Pharmacol. 17:1977;115-124.
41. Weil L., Seibles T. S. Reaction of reduced disulfide bonds in α-lactalbumin and β-lactoglobulin with acrylonitrile. Arch. Biochem. Biophys. 95:1961;470-473.
42. Westley A. M., Westley J. Voltammetric determination of cyanide and thiocyanate in small biological samples. Anal. Biochem. 181:1989;190-194.