Acto-myosin drug effects and aqueous outflow function

Investigative Ophthalmology and Visual Science

Volumn 40, Issue 1, 1999, Pages 74-81

  Epstein, David L ^a,b   Rowlette, Laura Leigh ^a   Roberts, Bruce C ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DUKE UNIVERSITY EYE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 2,3 BUTANEDIONE 2 MONOXIME; ACTIN; ADENOSINE TRIPHOSPHATASE (CALCIUM); LATRUNCULIN B; MYOSIN LIGHT CHAIN KINASE INHIBITOR; TUBULIN; UNCLASSIFIED DRUG;

ACTIN MYOSIN INTERACTION; ANIMAL CELL; AQUEOUS HUMOR OUTFLOW; ARTICLE; CELL ADHESION; CONTROLLED STUDY; DRUG EFFECT; GLAUCOMA; HUMAN; HUMAN CELL; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SWINE;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ACTINS; ANIMALS; AQUEOUS HUMOR; BICYCLO COMPOUNDS, HETEROCYCLIC; CELL SIZE; CELL SURVIVAL; CELLS, CULTURED; DIACETYL; MICROSCOPY, FLUORESCENCE; MYOSINS; SWINE; THIAZOLES; THIAZOLIDINES; TRABECULAR MESHWORK;

EID: 0032938489     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Kaufman PL, Barany EH. Cytochalasin B reversibly increases outflow facility in the eye of the cynomolgus monkey. Invest Ophthalmol Vis Sci. 1977;16:47-53.
2. Svedbergh B, Lütjen-Drecoll E, Ober M, Kaufman PL. Cytochalasin B-induced structural changes in the anterior ocular segment of the cynomolgus monkey. Invest Ophthalmol Vis Sci. 1978:17:718-734.
3. Johnstone M, Tanner D, Chau B, Kopecky K. Concentration-dependent morphologic effects of cytochalasin B in the aqueous outflow system. Invest Ophthalmol Vis Sci. 1980;19:835-841.
4. Erickson-Lamy KA, Schroeder A, Epstein DL. Ethacrynic acid induces reversible shape and cytoskeletal changes in cultured cells. Invest Ophthalmol Vis Sci. 1992:33:2631-2640.
5. Epstein DL, Roberts BC, Skinner LL. Non-sulfhydryl reactive phenoxyacetic acids increase aqueous humor outflow facility. Invest Ophthalmol Vis Sci. 1997;38:1526-1534.
6. Gills JP III, Roberts BC, Epstein DL. Microtubule disruption leads to cellular contraction in human trabecular meshwork cells. Invest Ophthalmol Vis Sci. 1998;39:653-658.
7. O'Brien ET, Epstein DL. Observation of living glaucoma cells by video DIC microscopy [ARVO Abstracts]. Invest Ophthalmol Vis Sci 1996:37(3):S895. Abstract nr 4146.
8. O'Brien ET, Perkins SL, Roberts BC, Epstein DL. Dexamethasone inhibits trabecular cell retraction. Exp Eye Res. 1996;62:675-688.
9. O'Brien ET, Kinch M, Harding T, Epstein DL. Ethacrynic acid dephosphorylates focal adhesion kinase in human trabecular meshwork cells. Exp Eye Res. 1997;65:471-483.
10. Tian B, Kaufman PL, Volberg T, Gabelt BT, Geiger B. H-7 disrupts the actin cytoskeleton and increases outflow facility. Arch Ophthalmol. 1998;116:633-643.
11. Volberg T, Geiger B, Citi S, Bershadsky AD. Effect of protein kinase inhibitor H-7 on the contractility, integrity, and membrane anchorage of the microfilament system. Cell Motil Cytoskeleton. 1994; 29:321-338.
12. Chrzanowska-Wodnicka M, Burridge K. Rho-stimulated contractility drives the formation of stress fibers and focal adhesions. J Cell Biol. 1996;133:1403-1415.
13. McKillop DF, Fortune NS, Ranatunga KW, Geeves MA. The influence of 2,3-butanedione 2-monoxime (BDM) on the interaction between actin and myosin in solution and in skinned muscle fibres. J Muscle Res Cell Motil. 1994;15:309-318.
14. Cramer LP, Mitchison TJ. Myosin is involved in postmitotic cell spreading. J Cell Biol. 1995;131:179-189
15. Zhao L, Naber N, Cooke R. Muscle cross-bridges bound to actin are disordered in the presence of 2,3-butanedione 2-monoxime. Biophys J. 1995;68:1980-1990.
16. Lyubimova A, Bershadsky AD, Ben-Ze'ev A. Autoregulation of actin synthesis responds to monomeric actin levels. J Cell Biochem. 1997;65:469-478.
17. Matthews JB, Smith JA, Hrnjez BJ. Effects of F-actin stabilization or disassembly on epithelial Cl-secretion and Na-K-2Cl cotransport. Am J Physiol. 1997;272:C254-C262.
18. Peterson JA, Tian B, Geiger B, Spector I, Kaufman PL. In cynomolgus monkeys Latrunculin (Lat)-A, Lat-B increase outflow facility, Lat-A decreases intraocular pressure and initially increases aqueous humor formation [ARVO Abstracts]. Invest Ophthalmol Vis Sci. 1997:38(4):S243. Abstract nr 1128.
19. Stamer WD, Roberts BC, Howell DN, Epstein DL. Isolation, culture, and characterization of endothelial cells from Schlemm's Canal. Invest Ophthalmol Vis Sci. 1998;39:1804-1812.
20. Epstein DL, Freddo TF, Bassett-Chu S, Chung M, Karageuzian L. Influence of ethacrynic acid on outflow facility in the monkey and calf eye. Invest Ophthalmol Vis Sci. 1987;28:2067-2075.
21. Epstein DL, Rohen JW. Morphology of the trabecular meshwork and inner-wall endothelium after cationized ferritin perfusion in the monkey eye. Invest Ophthalmol Vis Sci. 1991;32:160-171.
22. Liang L-L, Epstein DL, deKater AW, Shahsafaei A, Erickson-Lamy KA. Ethacrynic acid increases facility of outflow in the human eye in vitro. Arch Ophthalmol. 1992;110:106-109.
23. Johnson M, Shapiro A, Ethier CR, Kamm RD. Modulation of outflow resistance by the pores of the inner-wall endothelium. Invest Ophthalmol Vis Sci. 1992;33:1670-1675.
24. Epstein DL. Primary open angle glaucoma. In: Epstein DL, Allingham RR, Schuman JS, eds. Chandler and Grant's Glaucoma. 4th ed. Media, PA: Williams & Wilkins; 1997:194-197.
25. Citi S, Volberg T, Bershadsky AD, Denisenko N, Geiger B. Cytoskeletal involvement in the modulation of cell-cell junctions by the protein kinase inhibitor H-7. J Cell Sci. 1994;107:683-692.
26. Volberg T, Geiger B, Citi S, Bershadsky AD. Effect of protein kinase inhibitor H-7 on the contractility, integrity, and membrane anchorage of the microfilament system. Cell Motil Cytoskeleton. 1994; 29:321-338.
27. Dhamodharan R, Jordan MA, Thrower D, Wilson L, Wadsworth P. Vinblastine suppresses dynamics of individual microtubules in living interphase cells. Mol Biol Cell. 1995;6:1215-1229.
28. Lampidis TJ, Kolonias D, Savaraj N, Rubin RW. Cardiostimulatory and antiarrhythmic activity of tubulin-binding agents Proc Natl Acad Sci USA. 1992;89:1256-1260.
29. Xu S, Roychowdhury S, Gaskin F, Epstein DL. Ethacrynic acid inhibition of microtubule assembly in vitro Arch Biochem Biophys. 1992;296:462-467.
30. Ritch R, Mulberg A, Rosen C, Chubak G, Pokorny K, Yablonski M. The effect of colchicine on aqueous humor dynamics. Exp Eye Res. 1981;32:143-150.
31. Kolodney MS, Wysolmerski RB. Isometric contraction by fibroblasts and endothelial cells in tissue culture: a quantitative study. J Cell Biol. 1992;117:73-82.
32. Bershadsky A, Chausovsky A, Becker E, Lyubimova A, Geiger B. Involvement of microtubules in the control of adhesion-dependent signal transduction. Curr Biol. 1996;6:1279-1289.
33. Bershadsky A, Chausovsky A, Lyubimova B, Geiger B. Involvement of microtubules and cell contractility in the control of adhesion-dependent signal transduction (abstract). Mol Biol Cell. 1996; 7(Suppl):340.
34. Liu BP, Chrzanowska-Wodnicka M, Burridge K. Rho mediates nocodazole-induced stress fiber and focal adhesion formation (Abstract). Mol Biol Cell. 1996;7(Suppl):3055.
35. Danowski BA. Fibroblast contractility and actin organization are stimulated by microtubule inhibitors. J Cell Sci. 1989;93:255-266.
36. Liu X, Glasser A, Croft MA, Polansky JR, Fauss DJ, Kaufman PL. Effect of H-7 on cultured human trabecular meshwork (HTM) cells [ARVO Abstract], Invest Ophthalmol Vis Sci. 1998;39:5705. Abstract nr 3235.
37. Osterman A, Arner A, Malmqvist U. Effects of 2.3-butanedione 2-monoxime on activation of contraction and cross-bridge kinetics in intact and chemically skinned smooth muscle fibres from guinea pig taenia coli. J Muscle Res Cell Motil. 1993;14:186-194.
38. Braet F, DeZanger R, Jans D, Spector I, Wisse E. Microfilament-disrupting agent latrunculin A induces an increased number of fenestrae in rat liver sinusoidal endothelial cells: comparison with cytochalasin B. Hepatology 1996;24:627-635.
39. Peterson JA, Tian B, Kiland JA, et al. Latrunculin (Lat)-A, staurosporin, but not swinholde (swin)-A, increase outflow facility in the monkey [ARVO Abstracts]. Invest Ophthalmol Vis Sci 1996;37(3): S825. Abstract nr 3803.
40. Kolodney MS, Elson EL. Contraction due to microtubule disruption is associated with increased phosphorylation of myosin regulatory light chain. Proc Natl Acad Sci USA. 1995;92:10252-10256.
41. Citi S. Protein kinase inhibitors prevent junction dissociation induced by low extracellular calcium in MDCK epithelial cells. J Cell biol. 1992;117:169-178.
42. Denisenko N, Burighel P, Citi S. Different effects of protein kinase inhibitors on the localization of junctional proteins at cell-cell contact sites. J Cell Sci. 1994;107:969-981.
43. Citi S, Denisenko N. Phosphorylation of the tight junction protein cingulin and the effects of protein kinase inhibitors and activators in MDCK epithelial cells. J Cell Sci. 1995;108:2917-2926.
44. Mitton KP, Tumminia SJ, Arora J, Zelenka P, Epstein DL, Russell P. Transient loss of α B-crystallin: an early cellular response to mechanical stretch. Biochem Biophsy Res Commun. 1997;235:69-73.
45. Tumminia SJ, Mitton KP, Arora J, Zelenka P, Epstein DL, Russell P. Signal transduction induced by mechanical stretch in human trabecular meshwork cells. Invest Ophthalmol Vis Sci. 1998;39:1361-1371.
46. Trybus KM, Waller GS, Chatman TA. Coupling of ATPase activity and motility in smooth muscle myosin is mediated by the regulatory light chain. J Cell Biol. 1994;124:963-969.
47. Waterman-Storer C, Salmon ED. Actomyosin-based retrograde flow of microtubules in the lamella of migrating epithelial cells influences microtubule dynamic instability and turnover and is associated with microtubule breakage and treadmilling. J Cell Biol. 1997;139:417-434.
48. Stone EM, Fingert JH, Alward WLM, et al. Identification of a gene that causes primary open-angle glaucoma. Science. 1997; 275:668-670.
49. Kubota R, Noda S, Wang Y, et al. A novel myosin-like protein (myocilin) expressed in the connecting cilium of the photoreceptor: molecular cloning, tissue expression, and chromosomal mapping. Genomics. 1997;41:360-369