Metallothionein protects retinal pigment epithelial cells against apoptosis and oxidative stress

Experimental Eye Research

Volumn 74, Issue 1, 2002, Pages 83-92

  Lu, Huasheng ^a   Hunt, Diana Margaret ^a   Ganti, Ramapriya ^a   Davis, Alberta ^b   Dutt, Kamla ^c   Alam, Jawed ^d   Hunt, Richard C ^a  

^a UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b ALCON RESEARCH LTD   (United States)

^c MOREHOUSE SCHOOL OF MEDICINE   (United States)

^d OCHSNER MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Metallothionein; Oxidative stress; Retinal pigment epithelial cells

Indexed keywords

CADMIUM; GLUCOCORTICOID; HEME; INTERLEUKIN 1; IRON; METALLOTHIONEIN; OXYGEN; PROTEIN; TETRACYCLINE; TETRACYCLINE OPERATOR PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL PROTECTION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CULTURE MEDIUM; EYE PROTECTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; OXIDATIVE STRESS; PHOTORECEPTOR CELL; PIGMENT EPITHELIUM; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RETINA NERVE CELL; RETINA NEUROEPITHELIAL LAYER; ULTRAVIOLET RADIATION;

EID: 0036343594     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1006/exer.2001.1101     Document Type: Article

References (34)

1. Antisense down-regulation of metallothionein induces growth arrest and apoptosis in human breast carcinoma cells
2. Heme-hemopexin-mediated induction of metallothionein gene expression
3. Lipids of ocular tissues: VII Positional distribution of the fatty acids in the phospholipids of bovine retina rod outer segments
4. Transmission of the ocular media
5. Oxidative damage and protection of the RPE
6. Expression of antioxidant protective proteins in the rat retina during prenatal and postnatal development
7. Expression of the protective proteins hemopexin and haptoglobin by cells of the neural retina
8. Antioxidants and age-related eye disease. Current and future perspectives
9. Metallothionein protects DNA from oxidative damage
10. A human retinal pigment epithelial cell line that retains epithelial characteristics after prolonged culture
11. Growth of cultured RPE and endothelial cells is inhibited by blue light but not green or red light
12. Exudative age-related macular degeneration
13. Monoclonal antibody to single-stranded DNA is a specific and sensitive cellular marker of apoptosis
14. Apoptosis in breast carcinomas detected with monoclonal antibody to single-stranded DNA: Relation to bcl-2 expression, hormone receptors, and lymph node metastases
15. Novel function of metallothionein in photoprotection: Metallothionein-null mouse exhibits reduced tolerance against ultraviolet B injury in the skin
16. Preventive effect of antioxidants on lipid peroxidation in the retina
17. Transferrin receptors of the retinal pigment epithelium are associated with the cytoskeleton
18. Hemopexin in the human retina: Protection of the retina against heme-mediated toxicity
19. Metallothionein: An intracellular protein to protect against cadmium toxicity
20. Enhanced apoptosis in metallothionein null cells
21. Photic retinal injury
22. Evaluation of oxidative processes in human pigment epithelial cells associated with retinal outer segment phagocytosis
23. Induction, regulation, degradation, and biological significance of mammalian metallothioneins
24. Antioxidants in the retinal pigment epithelium
25. Studies on the mechanism of early onset macular degeneration in cynomolgus monkeys. II. Suppression of metallothionein synthesis in the retina in oxidative stress
26. Light history and age-related changes in retinal light damage
27. MT-III, a brain-specific member of the metallothionein gene family
28. CNS wound healing is severely depressed in metallothionein -1 and -2- deficient mice
29. Blue light-induced reactivity of retinal age pigment. In vitro generation of oxygen-reactive species
30. Analysis of the metallothionein gene in age-related macular degeneration
31. A reinvestigation of the fatty acid content of bovine, rat and frog outer segments
32. 2 induce catalase and metallothionein gene expression in human retinal pigment epithelial cells
33. Metallothionein shows an age-related decrease in human macular retinal pigment epithelium
34. Metallothionein expression prevents apoptosis: A study with antisense phosphorothioate oligodeoxynucleotides in a human T cell line