The release of 5-fluorouracil from microspheres of poly(ε- caprolactoneco-ethylene oxide)

Drug Development and Industrial Pharmacy

Volumn 26, Issue 1, 2000, Pages 7-12

  Martini, Luigi G ^a   Collett, John H ^b   Attwood, David ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Controlled release; Microspheres; Release mechanism; Swellable matrices

Indexed keywords

COPOLYMER; FLUOROURACIL; MACROGOL 4000; POLYCAPROLACTONE;

ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED RELEASE FORMULATION; DISSOLUTION; HYDRATION; MICROENCAPSULATION; PARTICLE SIZE; SCANNING ELECTRON MICROSCOPY;

ALGORITHMS; ANTIMETABOLITES, ANTINEOPLASTIC; EXCIPIENTS; FLUOROURACIL; KINETICS; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; PARTICLE SIZE; POLYESTERS; POLYETHYLENE GLYCOLS; SOLUBILITY;

EID: 0033959774     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.1081/DDC-100100321     Document Type: Article

References (12)

1. S. Benita, O. Zouai, and J.-P. Benoit, 5-Fluorouracil: carnauba wax microspheres for chemoembolization: an in vitro evaluation, J. Pharm. Sci., 75, 847-851 (1986).
2. R. Jeyanthi and K. Panduranga Rao, A novel method of preparation of gelatin microspheres for the controlled release of anticancer drugs, Proc. Int. Symp. Controlled Release Bioact. Mater, 15, 172-173 (1988).
3. K. C. Wright, S. Wallace, B. Mosier, and D. Mosier, Microcapsules for arterial chemoembolization: appearance and in vitro drug release characteristics, J. Microencapsulation, 5, 13-20 (1988).
4. L. G. Martini, J. H. Collett, and D. Attwood, The release of 5-fluorouracil from a swellable matrix of a triblock copolymer of ε-caprolactone and ethylene oxide, Pharm. Res., 12, 1786-1790 (1995).
5. L. Martini, D. Attwood, J. H. Collett, and A. D'Emanuele, The bioadhesive properties of a triblock copolymer of ε-caprolactone and ethylene oxide. Int. J. Pharm., 113, 223-229 (1995).
6. L. R. Beck, D. R. Cowsar, D. H. Lewis, R. J. Cosgrove, C. T. Riddle, S. L. Lowry, and T. Epperly, A new long-acting injectable microcapsule system for the administration of progesterone, Fertil. Steril., 31, 1721-1724 (1979).
7. P. Cerrai, M. Tricoli, F. Andruzzi, M. Paci, and M. Paci, Polyether-polyester block copolymers by non-catalysed polymerisation of ε-caprolactone with poly(ethylene glycol), Polymer, 30, 338-343 (1989).
8. 0 in aqueous solution, J. Chem. Soc. Faraday Trans., 90, 1961-1966 (1994).
9. E. Mathiowitz and R. Langer, Polyanhydrides microspheres as drug carriers 1. Hot-melt microencapsulation, J. Controlled Release, 5, 13-22 (1987).
10. M. Boisdron-Celle, J. M. Ruiz, and J.-P. Benoit, Preparation and characterization of 5-fluorouracil-loaded microspheres as biodegradable anti-cancer drug carriers, Proc. 6th Int. Conf. Pharm. Technol., APGI, 1, 52-61 (1992).
11. N. A. Peppas and J. J. Sahlin, A simple equation for description of solute release. III. Coupling of diffusion and relaxation, Int. J. Pharm., 57, 169-172 (1989).
12. J. L. Ford, K. Mitchell, P. Rowe, D. J. Armstrong, P. N. C. Elliot, C. Rostron, and J. E. Hogan, Mathematical modelling of drug release from hydroxypropylmethylcellulose matrices: effect of temperature, Int. J. Pharm., 71, 95-104 (1991).