Frequent occurrence of CYP2D6*10 duplication allele in a Japanese population

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 505, Issue 1-2, 2002, Pages 83-85

  Mitsunaga, Yoshiharu ^a   Kubota, Takahiro ^a   Ishiguro, Akihiro ^a   Yamada, Yasuhiko ^a   Sasaki, Hiroshi ^b   Chiba, Kan ^c   Iga, Tatsuji ^a  

^a UNIVERSITY OF TOKYO HOSPITAL   (Japan)

^b SRL INC   (Japan)

^c CHIBA UNIVERSITY   (Japan)

Author keywords

CYP2D6*10; Duplication; Japanese; Ultrarapid metabolizer

Indexed keywords

CYTOCHROME P450 2D6;

ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; FEMALE; GENE DUPLICATION; GENE FREQUENCY; HAPLOTYPE; HUMAN; JAPAN; MALE; NORMAL HUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ADULT; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; BIOTRANSFORMATION; CYTOCHROME P-450 CYP2D6; FEMALE; GENE DUPLICATION; GENE FREQUENCY; GENOTYPE; HAPLOTYPES; HUMANS; ISOENZYMES; JAPAN; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH;

EID: 0037194641     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(02)00122-7     Document Type: Article

References (9)

1. Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine
2. Ultrarapid hydroxylation of debrisoquine in Swedish population: Analysis of the molecular genetic basis
3. Frequent distribution of ultrarapid metabolizers of debrisoquine in an Ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles
4. Occurrence of CYP2D6 gene duplication in Hong Kong Chinese
5. Genetic analysis of the Chinese cytochrome P450 2D locus: Characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation
6. CYP2D6 genotypes in a Japanese population: Low frequencies of CYP2D6 gene duplication but high frequency of CYP2D6*10
7. Frequencies of CYP2D6 mutant alleles in a normal Japanese population and metabolic activity of dextromethorphan O-demethylation in different CYP2D6 genotypes
8. Ultrarapid drug metabolism: PCR-based detection of CYP2D6 gene duplication
9. Cytochrome P450 2D6 variants in a Caucasian population: Allele frequencies and phenotypic consequences