Common mutant alleles of CYP2D6 causing the defect of CYP2D6 enzyme activity in a Japanese population [2]

British Journal of Clinical Pharmacology

Volumn 55, Issue 4, 2003, Pages 414-

  Ishiguro, Akihiro ^a   Kubota, Takahiro ^a   Sasaki, Hiroshi ^b   Yamada, Yasuhiko ^a   Iga, Tatsuji ^a  

^a UNIVERSITY OF TOKYO HOSPITAL   (Japan)

^b SRL INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2D6; DEBRISOQUINE; NUCLEOTIDE;

ALLELE; CONFIDENCE INTERVAL; CONTROLLED STUDY; DNA SEQUENCE; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME DEFECT; ETHNIC DIFFERENCE; EXON; FEMALE; GENE CONVERSION; GENE FREQUENCY; GENE MUTATION; GENETIC DISORDER; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; IN VIVO STUDY; INFORMED CONSENT; JAPAN; LETTER; MAJOR CLINICAL STUDY; MALE; MUTANT; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

EID: 0038069498     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.2003.01782.x     Document Type: Letter

References (7)

1. Kubota T, Yamaura Y, Ohkawa N, Hara H, Chiba K. Frequencies of CYP2D6 mutant alleles in a normal Japanese population and metabolic activity of dextromethorphan O-demethylation in different CYP2D6 genotypes. Br J Clin Pharmacol 2000; 50: 31-34.
2. Mitsunaga Y, Kubota T, Ishiguro A et al. Frequent occurrence of CYP2D6* 10 duplication allele in a Japanese population. Mutat Res 2002; 505: 83-85.
3. Yokoi T, Kosaka Y, Chida M et at. A new CYP2D6 allele with a nine base insertion in exon 9 in a Japanese population associated with poor metabolizer phenotype. Pharmacogenetics 1996; 6: 395-401.
4. Chida M, Yokoi T, Nemoto N, Inaba M, Kinoshita M, Kamataki T. A new variant CYP2D6 allele (CYP2D6*21) with a single base insertion m exon 5 in a Japanese population associated with a poor metabolizer phenotype. Pharmacogenetics 1999; 9: 287-293.
5. Leathart JBS, London SJ, Steward A, Adams JD, Idle JR, Daly AK. CYP2D6 phenotype-genotype relationships in African-Americans and Caucasians in Los Angeles. Pharmacogenetics 1998; 8: 529-541.
6. Johansson I, Oscarson M, Yue QY, Bertilsson L, Sjöqvist F, Ingelman-Sundberg M. Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation. Mol Pharmacol 1994; 46: 452-459.
7. Nishida Y, Fukuda T, Yamamoto I, Azuma J. CYP2D6 genotypes in a Japanese population: low frequencies of CYP2D6 gene duplication but high frequency of CYP2D6*10. Pharmacogenetics 2000; 10: 567-570.