Influence of native and hypochlorite-modified low-density lipoprotein on gene expression in human proximal tubular epithelium

American Journal of Pathology

Volumn 164, Issue 6, 2004, Pages 2175-2187

  Porubsky, Stefan ^a   Schmid, Holger ^b   Bonrouhi, Mahnaz ^a   Kretzler, Matthias ^b   Malle, Ernst ^c   Nelson, Peter J ^b   Gröne, Hermann Josef ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID TRANSPORTER; AMINO ACID TRANSPORTER E16; COMPLEMENTARY DNA; CONNECTIVE TISSUE GROWTH FACTOR; CYTOCHROME B5 REDUCTASE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HALIDE; HEAT SHOCK PROTEIN 70; HEME OXYGENASE 1; HYDROGEN PEROXIDE; HYPOCHLORITE; HYPOCHLOROUS ACID; INTERLEUKIN 1BETA; LOW DENSITY LIPOPROTEIN; MATRILYSIN; MYELOPEROXIDASE; REACTIVE OXYGEN METABOLITE; THIOREDOXIN REDUCTASE; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN;

ADULT; AGED; ARTICLE; ATHEROGENESIS; CELL PROLIFERATION; CLINICAL ARTICLE; FEMALE; GENE CONTROL; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATION; INFLAMMATORY INFILTRATE; KIDNEY FUNCTION; KIDNEY PROXIMAL TUBULE; MALE; MEMBRANOUS GLOMERULONEPHRITIS; MINIMAL CHANGE GLOMERULONEPHRITIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEINURIA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 2442693043     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63775-3     Document Type: Article

References (53)

1. Tang S, Leung JC, Abe K, Chan KW, Chan LY, Chan TM, Lai KN: Albumin stimulates interleukin-8 expression in proximal tubular epithelial cells in vitro and in vivo. J Clin Invest 2003, 111:515-527
2. Benigni A, Zoja C, Remuzzi G: The renal toxicity of sustained glomerular protein traffic. Lab Invest 1995, 73:461-468
3. Moorhead JF: Lipids and progressive kidney disease. Kidney Int Suppl 1991, 31:S35-40
4. Gwinner W, Grone HJ: Role of reactive oxygen species in glomerulonephritis. Nephrol Dial Transplant 2000, 15:1127-1132
5. Johnson RJ, Couser WG, Chi EY, Adler S, Klebanoff SJ: New mechanism for glomerular injury: myeloperoxidase-hydrogen peroxide-halide system. J Clin Invest 1987, 79:1379-1387
6. Boyce NW, Tipping PG, Holdsworth SR: Glomerular macrophages produce reactive oxygen species in experimental glomerulonephritis. Kidney Int 1989, 35:778-782
7. Kettle AJ, Gedye CA, Winterbourn CC: Mechanism of inactivation of myeloperoxidase by 4-aminobenzoic acid hydrazide. Biochem J 1997, 321 (Pt 2):503-508
8. Hampton MB, Kettle AJ, Winterbourn CC: Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing. Blood 1998, 92:3007-3017
9. Hazell LJ, Stocker R: Oxidation of low-density lipoprotein with hypochlorite causes transformation of the lipoprotein into a high-uptake form for macrophages. Biochem J 1993, 290:165-172
10. Prutz WA: Hypochlorous acid interactions with thiols, nucleotides DNA, and other biological substrates. Arch Biochem Biophys 1996, 332:110-120
11. Winterbourn CC, Garcia RC, Segal AW: Production of the superoxide adduct of myeloperoxidase (compound III) by stimulated human neutrophils and its reactivity with hydrogen peroxide and chloride. Biochem J 1985, 228:583-592
12. Vissers MC, Winterbourn CC: The effect of oxidants on neutrophil-mediated degradation of glomerular basement membrane collagen. Biochim Biophys Acta 1986, 889:277-286
13. Grone HJ, Grone EF, Malle E: Immunohistochemical detection of hypochlorite-modified proteins in glomeruli of human membranous glomerulonephritis. Lab Invest 2002, 82:5-14
14. Vissers MC, Day WA, Winterbourn CC: Neutrophils adherent to a nonphagocytosable surface (glomerular basement membrane) produce oxidants only at the site of attachment. Blood 1985, 66:161-166
15. Matte E, Woenckhaus C, Waeg G, Esterbauer H, Grone EF, Grone HJ: Immunological evidence for hypochlorite-modified proteins in human kidney. Am J Pathol 1997, 150:603-615
16. Kamanna VS, Pai R, Roh DD, Kirschenbaum MA: Oxidative modification of low-density lipoprotein enhances the murine mesangial cell cytokines associated with monocyte migration, differentiation, and proliferation. Lab Invest 1996, 74:1067-1079
17. Marsche G, Zimmermann R, Horiuchi S, Tandon NN, Sattler W, Malle E: Class B scavenger receptors CD36 and SR-BI are receptors for hypochlorite-modified low density lipoprotein. J Biol Chem 2003, 278:47562-47570
18. Liao L, Aw TY, Kvietys PR, Granger DN: Oxidized LDL-induced microvascular dysfunction: dependence on oxidation procedure. Arterioscler Thromb Vasc Biol 1995, 15:2305-2311
19. Nguyen-Khoa T, Massy ZA, Witko-Sarsat V, Canteloup S, Kebede M, Lacour B, Drueke T, Descamps-Latscha B: Oxidized low-density lipoprotein induces macrophage respiratory burst via its protein moiety: a novel pathway in atherogenesis? Biochem Biophys Res Commun 1999, 263:804-809
20. Carr AC: Hypochlorous acid-modified low-density lipoprotein inactivates the lysosomal protease cathepsin B: protection by ascorbic and lipoic acids. Redox Rep 2001, 6:343-349
21. Kopprasch S, Leonhardt W, Pietzsch J, Kuhne H: Hypochlorite-modified low-density lipoprotein stimulates human polymorphonuclear leukocytes for enhanced production of reactive oxygen metabolites, enzyme secretion, and adhesion to endothelial cells. Atherosclerosis 1998, 136:315-324
22. Nuszkowski A, Grabner R, Marsche G, Unbehaun A, Malle E, Heller R: Hypochlorite-modified low density lipoprotein inhibits nitric oxide synthesis in endothelial cells via an intracellular dislocalization of endothelial nitric-oxide synthase. J Biol Chem 2001, 276:14212-14221
23. Ryan MJ, Johnson G, Kirk J, Fuerstenberg SM, Zager RA, Torok-Storb B: HK-2: an immortalized proximal tubule epithelial cell line from normal adult human kidney. Kidney Int 1994, 45:48-57
24. Katrantzis M, Baker MS, Handley CJ, Lowther DA: The oxidant hypochlorite (OCl-), a product of the myeloperoxidase system, degrades articular cartilage proteoglycan aggregate. Free Radic Biol Med 1991, 10:101-109
25. Malle E, Hazell L, Stocker R, Sattler W, Esterbauer H, Waeg G: Immunologic detection and measurement of hypochlorite-modified LDL with specific monoclonal antibodies. Arterioscler Thromb Vasc Biol 1995, 15:982-989
26. Cohen CD, Frach K, Schlondorff D, Kretzler M: Quantitative gene expression analysis in renal biopsies: a novel protocol for a high-throughput multicenter application. Kidney Int 2002, 61:133-140
27. Grone HJ, Cohen CD, Grone E, Schmidt C, Kretzler M, Schlondorff D, Nelson PJ: Spatial and temporally restricted expression of chemokines and chemokine receptors in the developing human kidney. J Am Soc Nephrol 2002, 13:957-967
28. Schmid H, Henger A, Cohen CD, Frach K, Grone HJ, Schlondorff D, Kretzler M: Gene expression profiles of podocyte-associated molecules as diagnostic markers in acquired proteinuric diseases. J Am Soc Nephrol 2003, 14:2958-2966
29. Diamond JR, Karnovsky MJ: Focal and segmental glomerulosclerosis: analogies to atherosclerosis. Kidney Int 1988, 33:917-924
30. Grone EF, Walli AK, Grone HJ, Miller B, Seidel D: The role of lipids in nephrosclerosis and glomerulosclerosis. Atherosclerosis 1994, 107:1-13
31. Joles JA, van Tol A, Jansen EH, Koomans HA, Rabelink TJ, Grond J, van Goor H: Plasma lipoproteins and renal apolipoproteins in rats with chronic adriamycin nephrosis. Nephrol Dial Transplant 1993, 8:831-838
32. Malle E, Waeg G, Schreiber R, Grone EF, Sattler W, Grone HJ: Immunohistochemical evidence for the myeloperoxidase/H2O2/halide system in human atherosclerotic lesions: colocalization of myeloperoxidase and hypochlorite-modified proteins. Eur J Biochem 2000, 267:4495-4503
33. Malle E, Buch T, Grone HJ: Myeloperoxidase in kidney disease. Kidney Int 2003, 64:1956-1967
34. Zager RA, Johnson AC, Hanson SY: Proximal tubular cholesterol loading after mitochondrial, but not glycolytic, blockade. Am J Physiol Renal Physiol 2003, 285:F1092-1099
35. Grewal T, de Diego I, Kirchhoff MF, Tebar F, Heeren J, Rinninger F, Enrich C: High density lipoprotein-induced signaling of the MAPK pathway involves scavenger receptor type BI-mediated activation of Ras. J Biol Chem 2003, 278:16478-16481
36. Fernando RL, Varghese Z, Moorhead JF: Differential ability of cells to promote oxidation of low density lipoproteins in vitro. Clin Chim Acta 1998, 269:159-173
37. Steinbrecher UP: Role of superoxide in endothelial-cell modification of low-density lipoproteins. Biochim Biophys Acta 1988, 959:20-30
38. Agarwal A, Nick HS: Renal response to tissue injury: lessons from heme oxygenase-1 gene ablation and expression. J Am Soc Nephrol 2000, 11:965-973
39. Otterbein LE, Choi AM: Heme oxygenase: colors of defense against cellular stress. Am J Physiol Lung Cell Mol Physiol 2000, 279:L1029-1037
40. Kanwar YS: Heme oxygenase-1 in renal injury: conclusions of studies in humans and animal models. Kidney Int 2001, 59:378-379
41. Tenhunen R, Marver HS, Schmid R: Microsomal heme oxygenase: characterization of the enzyme. J Biol Chem 1969, 244:6388-6394
42. Agarwal A, Balla J, Balla G, Croatt AJ, Vercellotti GM, Nath KA: Renal tubular epithelial cells mimic endothelial cells upon exposure to oxidized LDL. Am J Physiol 1996, 271:F814-823
43. Siow RC, Ishii T, Sato H, Taketani S, Leake DS, Sweiry JH, Pearson JD, Bannai S, Mann GE: Induction of the antioxidant stress proteins heme oxygenase-1 and MSP23 by stress agents and oxidised LDL in cultured vascular smooth muscle cells. FEBS Lett 1995, 368:239-242
44. Becker K, Gromer S, Schirmer RH, Muller S: Thioredoxin reductase as a pathophysiological factor and drug target. Eur J Biochem 2000, 267:6118-6125
45. Powis G, BRiehl M, Oblong J: Redox signalling and the control of cell growth and death. Pharmacol Ther 1995, 68:149-173
46. Schenk H, Vogt M, Droge W, Schulze-Osthof K: Thioredoxin as a potent costimulus of cytokine expression. J Immunol 1996, 156:765-771
47. Yoshida S, Katoh T, Tetsuka T, Uno K, Matsui N, Okamoto T: Involvement of thioredoxin in rheumatoid arthritis: its costimulatory roles in the TNF-α induces production of IL-6 and IL-8 from cultured synovial fibroblasts. J Immunol 1999, 163:351-358
48. Villalba J, Navas P: Plasma membrane redox system in the control of stress-induced apoptosis. Antioxid Redox Signal 2000, 2:213-230
49. Towndrow KM, Mertens J, Jeong JK, Weber TJ, Monks TJ, Lau SS: Stress- and growth-related gene expression are independent of chemical-induced prostaglandin E2 synthesis in renal epithelial cells. Chem Res Toxicol 2000, 13:111-117
50. Jeong J, Stevens J, Lau S, Monks T: Quinone thioether-mediated DNA damage, growth arrest and gadd153 expression in renal proximal tubular epithelial cells. Mol Pharmacol 1996, 50:592-598
51. Brigstock DR: Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61). Angiogenesis 2002, 5:153-165
52. Cross MJ, Dixelius J, Matsumoto T, Claesson-Welsh L: VEGF-receptor signal transduction. Trends Biochem Sci 2003, 28:488-494
53. Grone HJ, Simon M, Grone EF: Expression of vascular endothelial growth factor in renal vascular disease and renal allografts. J Pathol 1995, 177:259-267