Involvement of thioredoxin in rheumatoid arthritis: Its costimulatory roles in the TNF-α-induced production of IL-6 and IL-8 from cultured synovial fibroblasts

Journal of Immunology

Volumn 163, Issue 1, 1999, Pages 351-358

  Yoshida, Shinichi ^a   Katoh, Tetsuji ^a   Tetsuka, Toshifumi ^a   Uno, Kazuko ^b   Matsui, Nobuo ^a   Okamoto, Takashi ^a  

^a NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

^b Louis Pasteur Center for Medical Research   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; C REACTIVE PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; SERINE; THIOREDOXIN; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FIBROBLAST; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SYNOVIAL FLUID LEVEL;

ADJUVANTS, IMMUNOLOGIC; ADULT; AGED; AGED, 80 AND OVER; ARTHRITIS, RHEUMATOID; BIOLOGICAL TRANSPORT; C-REACTIVE PROTEIN; CELL NUCLEUS; CELLS, CULTURED; DNA-BINDING PROTEINS; FEMALE; FIBROBLASTS; HUMANS; I-KAPPA B PROTEINS; INTERLEUKIN-6; INTERLEUKIN-8; MALE; MIDDLE AGED; NF-KAPPA B; OSTEOARTHRITIS; REGRESSION ANALYSIS; SYNOVIAL FLUID; THIOREDOXIN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033168698     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. Badolato, R., and J. J. Oppenheim. 1996. Role of cytokines, acute-phase proteins, and chemokines in the progression of rheumatoid arthritis. Semin. Arthritis Rheum. 26:526.
2. Feldmann, M., F. M. Brennan, and R. N. Maini. 1996. Role of cytokines in rheumatoid arthritis. Ann. Rheum. Dis. 14:397.
3. Heinrich, P. C., J. V. Castell, and T. Andus. 1990. Interleukin-6 and the acute phase response. Biochem. J. 265:621.
4. Houssiau, F. A., J. P. Devogelaer, J. V. Damme, C. N. deDeuxchaisnes, and J. V. Snick. 1988. Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides. Arthritis Rheum. 31:784.
5. Alvato-Gracia, J. M., N. J. Zvaifler, C. B. Brown, K. Kaushansky, and G. S. Firestein. 1991. Cytokines in chronic arthritis. VI. Analysis of the synovial cells involved in granulocyte macrophage colony-stimulating factor production and gene expression in rheumatoid arthritis and its regulation by IL-1 and TNF-α. J. Immunol. 146:3365.
6. Arend, W. P., and J. M. Dayer. 1995. Inhibition of the production and effects of interleukin-1 and tumor necrosis factor α in rheumatoid arthritis. Arthritis Rheum. 38:151.
7. Van Leeuwen, M. A., J. Westra, P. C. Limburg, P. L. C. M. van Riel, and M. H. van Rijswijk. 1995. Interleuikin-6 in relation to other proinflammatory cytokines, chemotactic activity and neutrophil activation in rheumatoid synovial fluid. Ann. Rheum. Dis. 54:33.
8. Remick, D. G., L. E. DeForge, J. F. Sullivan, and H. J. Showell. 1992. Profile of cytokines in synovial fluid specimen from patients with arthritis: interleukin 8 (IL-8) and IL-6 correlation with inflammatory arthritides. Immun. Invest. 21:321.
9. Sakurada, S., T. Kato, and T. Okamoto. 1996. Induction of cytokines and ICAM-1 by proinflammatory cytokines in primary rheumatoid synovial fibroblasts and inhibition by N-acetyl-L-cysteine and aspirin. Int. Immunol. 8:1483.
10. Yoshida, S., T. Kato, S. Sakurada, C. Kurono, Y. J. Yang, N. Matsui, T. Soji, and T. Okamoto. 1999. Inhibition of IL-6 and IL-8 induction from the cultured rheumatoid synovial fibroblasts by treatment with aurothioglucose. Int. Immunol. 11:151.
11. Castell, J. V., M. J. Gomez-Lechon, M. David, T. Hirano, T. Kishimoto, and P. C. Heinrich. 1988. Recombinant human interleukin-6 (IL-6/BDSF-2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes. FEBS Lett. 232:347.
12. Ganapathi, M. K., L. Y. May, D. Schultz, A. Brabenec, J. Weinstein, P. B. Sehgal, and I. Kushner. 1988. Role of interleukin-6 in regulating synthesis of C-reactive protein and serum amyloid A in human hepatoma cell lines. Biochem. Biophys. Res. Commun. 157:271.
13. Okamoto, H., M. Yamamura, Y. Morita, S. Harada, H. Makino, and Z. Ota. 1997. The synovial expression and serum levels of interleukin-6, interleukin-11, leukemia inhibitory factor, and oncostatin M in rheumatoid arthritis. Arthritis Rheum. 40:1096.
14. Lacki, J. K., W. Samborski, and S. H. Mackiewicz. 1997. Interleukin-10 and interleukin-6 in lupus erythematosus and rheumatoid arthritis: correlation with acute phase protein. Clin. Rheumatol. 16:275.
15. Davis, L. S., A. F. Kavanaugh, L. A. Nichols, and P. E. Lipsky. 1995. Induction of persistent T cell hyporesponsiveness in vivo by monoclonal antibody to ICAM-1 in patients with rheumatoid arthritis. J. Immunol. 154:3525.
16. Wilkinson, L. S., J. C. W. Edwards, R. N. Poston, and D. O. Haskard. 1993. Expression of vascular cell adhesion molecule-1 in normal and inflamed synovium. Lab. Invest. 68:82.
17. Elliott, M. J., R. N. Maini, M. Feldmann, A. Long-Fox, P. Charles, P. Katsikis, F. M. Brennan, J. Walker, H. Bijl, J. Ghrayeb, and J. N. Woody. 1993. Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α. Arthritis Rheum. 36:1681.
18. Baeuerle, P. A. 1991. The inducible transcription activator NF-κB: regulation by distinct protein subunit. Biochem. Biophys. Acta 1072:63.
19. Mukaida, N., Y. Mahe, and K. Matsushima. 1990. Cooperative interaction of nuclear factor-κB and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines. J. Biol. Chem. 265:21128.
20. Sen, R., and D. Baltimore. 1986. Multiple nuclear factors interact with the immunoglobulin enhancer-binding sequence. Cell. 46:705.
21. Ledebur, H. C., and T. P. Parks. 1995. Transcriptional regulation of the intercellular adhesion molecule-1 gene by inflammatory cytokines in human endothelial cells: essential role of a variant NF-κB site and p65 homodimers. J. Biol. Chem. 270:933.
22. Handel, M. L., L. B. McMorrow, and E. M. Gravallese. 1995. Nuclear factor-κB in rheumatoid synovium: localization of p50 and p65. Arthritis Rheum. 38:1762.
23. Marok, R., P. G. Winyard, A. Coumbe, M. L. Kus, K. Gaffney, S. Blades, P. I. Mapp, C. J. Morris, D. R. Blake, C. Kaltschmidt, and P. A. Baeuerle. 1996. Activation of the transcriptional factor nuclear factor-κB in human inflamed synovial tissue. Arthritis Rheum. 39:583.
24. Kopp, E., and S. Ghosh. 1994. Inhibition of NF-κB by sodium salicylate and aspirin. Science 265:956.
25. Scheinman, R. I., P. C. Cogswell, A. K. Lofquist, and A. S. Baldwin, Jr. 1995. Role of transcriptional activation of IκB α in mediation of immunosuppression by glucocorticoids. Science 270:283.
26. Auphan, N., J. A. DiDonato, C. Rosette, A. H elmberg, and M. Karin. 1995. Immunosuppression by glucocorticoids: inhibition of NF-κB activity through induction of IκB synthesis. Science 270:286.
27. Yang, J. P., J. P. Merin, T. Nakano, T. Kato, Y. Kitade, and T. Okamoto. 1995. Inhibition of the DNA-binding activity of NF-κB by gold compounds in vitro. FEBS Lett. 361:89.
28. Yin, M. J., Y. Yamamoto, and R. B. Gaynor. 1998. The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β. Nature 396:77.
29. Baeuerle, P. A., and D. Baltimore. 1988. I κB: a specific inhibitor of the NF-κB transcription factor. Science 242:540.
30. Halliwell, B., J. R. Hoult and D. R. Blake. 1988. Oxidants, inflammation, and anti-inflammatory drugs. FASEB J. 2:2867.
31. Blake, D. R., P. Merry, J. Unsworth, B. L. Kidd, J. M. Outhwaite, R. Ballard, C. J. Morris, L. Gray, and J. Lunec. 1989. Hypoxic-reperfusion injury in the inflamed human joint. Lancet. 1:289.
32. Mapp, P. I., M. C. Grootveld, and D. R. Blake. 1995. Hypoxia, oxidative stress and rheumatoid arthritis. Br. Med. Bull. 51:419.
33. Grootveld, M., E. B. Henderson, A. Farrell, D. R. Blake, H. G. Parker, and P. Haycock. 1991. Oxidative damage to hyaluronate and glucose in synovial fluid during exercise of the inflamed rheumatoid joint. Biochem. J. 273:459.
34. Lunec, J., and D. R. Blake. 1985. The determination of dehydroascorbic acid and ascorbic acid in serum and synovial fluid of patients with rheumatoid arthritis. Free Radical Res. Commun. 1:31.
35. Okamoto, T., H. Ogiwara, T. Hayashi, A. Mitsui, T. Kawabe, and J. Yodoi. 1992. Human thioredoxin/adult T cell leukemia-derived factor activates the enhancer binding protein of human immunodeficiency virus type 1 by thiol redox control mechanism. Int. Immunol. 4:811.
36. Hayashi, T., Y. Ueno, and T. Okamoto. 1993. Oxidoreductive regulation of nuclear factor κB: involvement of a cellular reducing catalyst thioredoxin. J. Biol. Chem. 268:11380.
37. Qin, J., G. M. Clore, W. M. P. Kennedy, J. R. Huth, and A. M. Gronenborn. 1995. Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NF-κB. Structure 3:289.
38. Okamoto, T., S. Sakurada, J. P. Yang, and J. P. Merin. 1997. Regulation of NF-κB and disease control: identification of a novel serine kinase and thioredoxin as effectors for signal transduction pathway for NF-κB activation. Curr. Top. Cell Regul. 35:149.
39. Sachi, Y., K. Hirota, H. Masutani, K. Toda, T. Okamoto, M. Takigawa, and J. Yodoi. 1995. Induction of ADF/TRX by oxidative stress in keratinocytes and lymphoid cells. Immunol. Lett. 44:189.
40. Wakasugi, H., L. Rimsky, Y. Mahe, A. M. Kamel, D. Fradelizi, T. Tursz, and J. Bertoglio. 1987. Epstein-Barr virus-containing B-cell line produces an interleukin 1 that it uses as a growth factor. Proc. Natl. Acad. Sci. USA 84:804.
41. Tagaya, Y., Y. Maeda, A. Mitsui, N. Kondo, H. Matsui, J. Hamuro, N. Brown, K. Arai, T. Yokota, H. Wakasugi, and J. Yodoi. 1989. ATL-derived factor (ADF), an IL-2 receptor/Tac inducer homologous to thioredoxin; possible involvement of dithiol-reduction in the IL-2 receptor induction. EMBO J. 8:757.
42. Schenk, H., M. Vogt, W. Droge, and K. Schulze-Osthoff. 1996. Thioredoxin as a potent costimulus of cytokine expression. J. Immunol. 156:765.
43. Arnett, F. C., S. M. Edworthy, D. A. Bloch, D. J. McShane, J. F. Fries, N. S. Cooper, L. A. Healey, S. R. Kaplan, M. H. Liang, H. S. Luthra, et al. 1987. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 31:315.
44. Nakamura, H., S. De Rosa, M. Roederer, M. T. Anderson, J. G. Dubs, J. Yodoi, A. Holmgren, L. A. Herzenberg, and L. A. Herzenberg. 1996. Elevation of plasma thioredoxin levels in HIV-infected individuals. Int. Immunol 8:603.
45. Asamitsu, K., S. Sakurada, T. Kawabe, K. Mashiba, K. Nakagawa, K. Torikai, K. Onozaki and T. Okamoto. 1998. Alteration of the cellular response to interleukin-1β by SV40 large T antigen in rheumatoid synovial fibroblasts. Arch. Virol. 143:1.
46. Tozawa, K., S. Sakurada, K. Kohri, and T. Okamoto. 1995. Effects of anti-nuclear factor κB reagents in blocking adhesion of human cancer cells to vascular endothelial cells. Cancer Res. 55:4162.
47. Libermann, T. A., and D. Baltimore. 1990. Activation of interleukin-6 gene expression through the NF-κB transcription factor. Mol. Cell. Biol. 10:2327.
48. Maurice, M. M., H. Nakamura, E. A. M. van der Voort, A. I. van Vliet, F. J. T. Staal, P. P. Tak, F. C. Breedveld, and C. L. Verweij. 1997. Evidence for the role of an altered redox state in hyporesponsiveness of synovial T cells in rheumatoid arthritis. J. Immunol. 158:1458.
49. Taniguchi, Y., Y. Taniguchi-Ueda, K. Mon, and J. Yodoi. 1996. A novel promoter sequence is involved in the oxidative stress-induced expression of the adult T-cell leukemia-derived factor (ADF)/human thioredoxin (Trx) gene. Nucleic Acids Res. 24:2746.
50. Rothe, M., V. Sarma, V. M. Dixit, and D. V. Goeddel. 1995. TRAF-2 mediated activation of NF-κB by TNF receptor 2 and CD40. Science 269:1424.
51. Malinin, N. L., M. P. Boldin, A. V. Kovalenko, and D. Wallach. 1997. MAP3K-related kinase involved in NF-κB induction by TNF and IL-1. Nature 385:540.
52. Zandi, E., DD. M. Rothwarf, M. Delhase, M. Hayakawa, and M. Karin. 1997. The IκB kinase complex(IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation. Cell. 91:243.
53. Woronicz, J. D., X. Gao, Z. Cao, M. Rothe, and D. V. Goeddel. 1997. IκB kinase-β: NF-κB activation and complex formation with IκB kinase-α and NIK. Science 278:866.
54. Schreck, R., P. Rieber, and P. A. Baeuerle. 1991. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1. EMBO J. 10:2247.
55. Toledano, M. B., and W. J. Leonard. 1991. Modulation of transcription factor NF-κB binding activity by oxidation-reduction in vitro. Proc. Natl. Acad. Sci. USA 88:4328.
56. Matthews, J. R., N. Wakasugi, J. L. Virelizier, J. Yodoi, and R. T. Hay. Thioredoxin regulates the DNA binding activity of NF-κB by reduction of a disulfide bond involving cysteine 62. Nucleic Acids Res. 20:3821.