메뉴 건너뛰기




Volumn 9, Issue , 2004, Pages 1720-1727

Antisense therapeutics and the treatment of CNS disease

Author keywords

Antisense; Blood brain barrier; Brain; Central nervous system; Oligonucleotide; Review

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PROTEIN; ANTISENSE OLIGONUCLEOTIDE; DEOXYRIBONUCLEOTIDE; ENVELOPE PROTEIN; GLYCOPROTEIN GP 120; GLYCOPROTEIN P; PEPTIDE NUCLEIC ACID; PHOSPHOROTHIOIC ACID; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE C; PROTEIN MCL 1; VIRUS DNA;

EID: 2442682040     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/1337     Document Type: Review
Times cited : (8)

References (47)
  • 2
    • 0029966767 scopus 로고    scopus 로고
    • Inhibition of expression of the multidrug resistance-associated P-glycoprotein by phosphorothioate and 5′ cholesterol-conjugated phosphorothioate antisense oligonucleotides
    • Alahari, S. K., N. M. Dean, M. H. Fisher, R. Delong, M. Manoharan, K.L. Tivel and R.L. Juliano: Inhibition of expression of the multidrug resistance-associated P-glycoprotein by phosphorothioate and 5′ cholesterol-conjugated phosphorothioate antisense oligonucleotides. Mol Pharmacol 50, 808-819 (1996)
    • (1996) Mol Pharmacol , vol.50 , pp. 808-819
    • Alahari, S.K.1    Dean, N.M.2    Fisher, M.H.3    Delong, R.4    Manoharan, M.5    Tivel, K.L.6    Juliano, R.L.7
  • 3
    • 0035015218 scopus 로고    scopus 로고
    • Delivery across the blood-brain barrier of antisense directed against amyloid β: Reversal of learning and memory deficits in mice overexpressing amyloid precursor protein
    • Banks, W. A., S. A. Farr, W. Butt, V. B. Kumar, M. W. Franko and J. E. Morley: Delivery across the blood-brain barrier of antisense directed against amyloid β: reversal of learning and memory deficits in mice overexpressing amyloid precursor protein. J Pharmacol Exp Ther 297, 1113-1121 (2001)
    • (2001) J Pharmacol Exp Ther , vol.297 , pp. 1113-1121
    • Banks, W.A.1    Farr, S.A.2    Butt, W.3    Kumar, V.B.4    Franko, M.W.5    Morley, J.E.6
  • 4
    • 0035037852 scopus 로고    scopus 로고
    • Transport of human immunodeficiency virus type 1 pseudoviruses across the blood-brain barrier: Role of envelope proteins and adsorptive endocytosis
    • Banks, W. A., E. O. Freed, K. A. Wolf, S. M. Robinson, M. Franko and V. B. Kumar: Transport of human immunodeficiency virus type 1 pseudoviruses across the blood-brain barrier: role of envelope proteins and adsorptive endocytosis. J Virol 75, 4681-4691 (2001)
    • (2001) J Virol , vol.75 , pp. 4681-4691
    • Banks, W.A.1    Freed, E.O.2    Wolf, K.A.3    Robinson, S.M.4    Franko, M.5    Kumar, V.B.6
  • 6
    • 0029066919 scopus 로고
    • Antisense drug delivery through the blood-brain barrier
    • Boado, R. J. Antisense drug delivery through the blood-brain barrier. Adv Drug Del Rev 15, 73-107 (1995)
    • (1995) Adv Drug Del Rev , vol.15 , pp. 73-107
    • Boado, R.J.1
  • 7
    • 0028857672 scopus 로고
    • Rapid plasma clearance and metabolism in vivo of a phosphorothioate oligodeoxynucleotide with a single, internal phosphodiester bond
    • Boado, R. J., Y. S. Kang, D. Wu and W. M. Pardridge: Rapid plasma clearance and metabolism in vivo of a phosphorothioate oligodeoxynucleotide with a single, internal phosphodiester bond. Drug Metab Dispos 23, 1297-1300 (1995)
    • (1995) Drug Metab Dispos , vol.23 , pp. 1297-1300
    • Boado, R.J.1    Kang, Y.S.2    Wu, D.3    Pardridge, W.M.4
  • 8
    • 0037333165 scopus 로고    scopus 로고
    • Minimally modified phosphodiester antisense oligodeoxyribonucleotide directed against the multidrug resistance gene mdrl
    • Brigui, I., T. Djavanbakht-Samani, B. Joll̀es, S. Pigaglio and A. Laigle: Minimally modified phosphodiester antisense oligodeoxyribonucleotide directed against the multidrug resistance gene mdrl. Biochem Pharm 65, 747-754 (2003)
    • (2003) Biochem Pharm , vol.65 , pp. 747-754
    • Brigui, I.1    Djavanbakht-Samani, T.2    Joll̀es, B.3    Pigaglio, S.4    Laigle, A.5
  • 9
    • 0033586323 scopus 로고    scopus 로고
    • Transmission routes of HIV-1 gp120 from brain to lymphoid tissues
    • Cashion, M. F., W. A. Banks, K. L. Bost and A. J. Kastin: Transmission routes of HIV-1 gp120 from brain to lymphoid tissues. Brain Res 822, 26-33 (1999)
    • (1999) Brain Res , vol.822 , pp. 26-33
    • Cashion, M.F.1    Banks, W.A.2    Bost, K.L.3    Kastin, A.J.4
  • 10
    • 0028270064 scopus 로고
    • Hydrogen bonding potential as a determinant of the in vitro and in situ blood-brain barrier permeability of peptides
    • Chikhale, E. G., K. Y. Ng, P. S. Burton and R. T. Borchardt: Hydrogen bonding potential as a determinant of the in vitro and in situ blood-brain barrier permeability of peptides. Pharm Res 11, 412-419 (1994)
    • (1994) Pharm Res , vol.11 , pp. 412-419
    • Chikhale, E.G.1    Ng, K.Y.2    Burton, P.S.3    Borchardt, R.T.4
  • 11
    • 0025095302 scopus 로고
    • Role of amino acid transport and countertransport in nutrition and metabolism
    • Christensen, H. N: Role of amino acid transport and countertransport in nutrition and metabolism. Physiol Rev 70, 43-77 (1990)
    • (1990) Physiol Rev , vol.70 , pp. 43-77
    • Christensen, H.N.1
  • 12
    • 0021794208 scopus 로고
    • The blood-brain barrier, a dynamic regulatory interface
    • Cornford, E. M: The blood-brain barrier, a dynamic regulatory interface. Mol Physiol 7, 219-260 (1985)
    • (1985) Mol Physiol , vol.7 , pp. 219-260
    • Cornford, E.M.1
  • 13
    • 0026721173 scopus 로고
    • Therapeutic applications of oligonucleotides
    • Crooke, S. T: Therapeutic applications of oligonucleotides. Annu Rev Pharmacol Toxicol 32, 329-376 (1992)
    • (1992) Annu Rev Pharmacol Toxicol , vol.32 , pp. 329-376
    • Crooke, S.T.1
  • 16
    • 0032546817 scopus 로고    scopus 로고
    • HIV-1 Regulatory/Accessory Genes: Keys to Unraveling Viral and Host Cell Biology
    • Emerman, M. and M. H. Malim: HIV-1 Regulatory/Accessory Genes: Keys to Unraveling Viral and Host Cell Biology. Science 280, 1880-1884 (1998)
    • (1998) Science , vol.280 , pp. 1880-1884
    • Emerman, M.1    Malim, M.H.2
  • 18
    • 0021256895 scopus 로고
    • Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
    • Glenner, G. G., C. W. Wong: Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem and Biophys Res Comm 120, 885-890 (1994)
    • (1994) Biochem and Biophys Res Comm , vol.120 , pp. 885-890
    • Glenner, G.G.1    Wong, C.W.2
  • 19
    • 0000876636 scopus 로고
    • Measurement of macromolecular binding using electrospray mass spectrometry. Determination of disassociation constants for oligonucleotide: serum albumin complexes
    • Greig, M. J., H. Gaus, L. L. Cummins, H. Sasmor and R. H. Griffey: Measurement of macromolecular binding using electrospray mass spectrometry. Determination of disassociation constants for oligonucleotide:serum albumin complexes. J Am Chem Soc 117, 10765-10766 (1995)
    • (1995) J Am Chem Soc , vol.117 , pp. 10765-10766
    • Greig, M.J.1    Gaus, H.2    Cummins, L.L.3    Sasmor, H.4    Griffey, R.H.5
  • 20
    • 0037718417 scopus 로고    scopus 로고
    • Inhibition of HIV Tat-TAR interactions by an antisense oligo-2′-O-methylribonucleoside methylphosphonate
    • Hamma, T., A. Saleh, I. Huq, T. M. Rana and P. S. Miller: Inhibition of HIV Tat-TAR interactions by an antisense oligo-2′-O-methylribonucleoside methylphosphonate. Bioorg Med Chem Lett 13, 1845-1848 (2003)
    • (2003) Bioorg Med Chem Lett , vol.13 , pp. 1845-1848
    • Hamma, T.1    Saleh, A.2    Huq, I.3    Rana, T.M.4    Miller, P.S.5
  • 21
    • 0014801394 scopus 로고
    • Enzyme degrading the RNA moiety of DNA/RNA hybrids
    • Hausen, P., H. Stein and H. Ribonuclease: Enzyme degrading the RNA moiety of DNA/RNA hybrids. Eur J Biochem 14, 278-283 (1970)
    • (1970) Eur J Biochem , vol.14 , pp. 278-283
    • Hausen, P.1    Stein, H.2    Ribonuclease, H.3
  • 22
    • 0033812002 scopus 로고    scopus 로고
    • Heterocyclic modifications of oligonucleotides and antisense technology
    • Herdewijn, P: Heterocyclic modifications of oligonucleotides and antisense technology. Antisense and Nucleic Acid Drug Dev 10, 297-310 (2000)
    • (2000) Antisense and Nucleic Acid Drug Dev , vol.10 , pp. 297-310
    • Herdewijn, P.1
  • 23
    • 0028290825 scopus 로고
    • Control of RNA initiation and elongation at the HIV-1 promoter
    • Jones, K. A. and B. M. Peterlin: Control of RNA initiation and elongation at the HIV-1 promoter. Annu Rev Biochem 63, 717-743 (1994)
    • (1994) Annu Rev Biochem , vol.63 , pp. 717-743
    • Jones, K.A.1    Peterlin, B.M.2
  • 24
  • 25
  • 26
    • 0025126177 scopus 로고
    • A morphometric study on the development of the lateral ventricle choroid plexus, choroid plexus capillaries and ventricular ependyma in the rat
    • Keep, R. F. and H. C. Jones: A morphometric study on the development of the lateral ventricle choroid plexus, choroid plexus capillaries and ventricular ependyma in the rat. Brain Res Dev Brain Res 56, 47-53 (1990)
    • (1990) Brain Res Dev Brain Res , vol.56 , pp. 47-53
    • Keep, R.F.1    Jones, H.C.2
  • 29
    • 0036675588 scopus 로고    scopus 로고
    • Using peptide nucleic acids as gene-expression modifiers to reduce β-amyloid levels
    • McMahon, B. M., J. Stewart, A. Fauq, S. Younkin, L. Younkin and E. Richelson: Using peptide nucleic acids as gene-expression modifiers to reduce β-amyloid levels. J Mol Neurosci 19, 71-76 (2002)
    • (2002) J Mol Neurosci , vol.19 , pp. 71-76
    • McMahon, B.M.1    Stewart, J.2    Fauq, A.3    Younkin, S.4    Younkin, L.5    Richelson, E.6
  • 30
    • 0035933505 scopus 로고    scopus 로고
    • Intraperitoneal injection of antisense peptide nucleic acids targeted to the mu receptor decreases response to morphine and receptor protein levels in rat brain
    • McMahon, B. M., J. A. Stewart, J. Jackson, A. Fauq, D. J. McCormick and E. Richelson: Intraperitoneal injection of antisense peptide nucleic acids targeted to the mu receptor decreases response to morphine and receptor protein levels in rat brain. Brain Res 904, 345-349 (2001)
    • (2001) Brain Res , vol.904 , pp. 345-349
    • McMahon, B.M.1    Stewart, J.A.2    Jackson, J.3    Fauq, A.4    McCormick, D.J.5    Richelson, E.6
  • 32
    • 0027436826 scopus 로고
    • Human immunodeficiency virus infection of human brain capillary endothelial cells occurs via a CD4/galactosylceramide-independent mechanism
    • Moses, A. V., F. E. Bloom, C. D. Pauza and J. A. Nelson: Human immunodeficiency virus infection of human brain capillary endothelial cells occurs via a CD4/galactosylceramide-independent mechanism. Proc Natl Acad Sci U S A 90, 10474-10478 (1993)
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 10474-10478
    • Moses, A.V.1    Bloom, F.E.2    Pauza, C.D.3    Nelson, J.A.4
  • 33
    • 0026341239 scopus 로고
    • Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide
    • Nielsen, P. E., M. Egholm, R. H. Berg and O. Buchardt: Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide. Science 254, 1497-1500 (1991)
    • (1991) Science , vol.254 , pp. 1497-1500
    • Nielsen, P.E.1    Egholm, M.2    Berg, R.H.3    Buchardt, O.4
  • 34
    • 0016354690 scopus 로고
    • Lipid-solubility and drug penetration of the blood-brain barrier
    • Oldendorf, W. H: Lipid-solubility and drug penetration of the blood-brain barrier. Proc Soc Exp Biol Med 147, 813-816 (1973)
    • (1973) Proc Soc Exp Biol Med , vol.147 , pp. 813-816
    • Oldendorf, W.H.1
  • 35
    • 0025123704 scopus 로고
    • Brain-type glucose transporter (GLUT-1) is selectively localized to the blood-brain barrier. Studies with quantitative western blotting and in situ hybridization
    • Pardridge, W. M., R. J. Boado and C. R. Farrell: Brain-type glucose transporter (GLUT-1) is selectively localized to the blood-brain barrier. Studies with quantitative western blotting and in situ hybridization. J Biol Chem 265, 18035-18040 (1990)
    • (1990) J Biol Chem , vol.265 , pp. 18035-18040
    • Pardridge, W.M.1    Boado, R.J.2    Farrell, C.R.3
  • 36
    • 0029079310 scopus 로고
    • Vector-mediated delivery of a polyamide ("peptide") nucleic acid analogue through the blood-brain barrier in vivo
    • Pardridge, W. M., R. J. Boado and Y. S. Kang: Vector-mediated delivery of a polyamide ("peptide") nucleic acid analogue through the blood-brain barrier in vivo. Proc Natl Acad Sci U S A 92, 5592-5596 (1995)
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 5592-5596
    • Pardridge, W.M.1    Boado, R.J.2    Kang, Y.S.3
  • 37
    • 0023684537 scopus 로고
    • Differences between vascular and plaque core amyloid in Alzheimer's disease
    • Prelli, F., E. M. Castaño, G. G. Glenner and B. Frangione: Differences between vascular and plaque core amyloid in Alzheimer's disease. J Neurochem 51, 648-651 (1988)
    • (1988) J Neurochem , vol.51 , pp. 648-651
    • Prelli, F.1    Castaño, E.M.2    Glenner, G.G.3    Frangione, B.4
  • 38
    • 0028958030 scopus 로고
    • Bcl-2: Prevention of apoptosis as a mechanism of drug resistance
    • Reed, J. C: Bcl-2: prevention of apoptosis as a mechanism of drug resistance. Hematol Oncol Clin North Am 9, 451-473 (1995)
    • (1995) Hematol Oncol Clin North Am , vol.9 , pp. 451-473
    • Reed, J.C.1
  • 40
    • 0027376439 scopus 로고
    • Antisense oligonucleotides as therapeutic agents: Is the bullet really magical?
    • Stein, C. A. and Y. C. Cheng: Antisense oligonucleotides as therapeutic agents: is the bullet really magical? Science 261, 1004-1012 (1993)
    • (1993) Science , vol.261 , pp. 1004-1012
    • Stein, C.A.1    Cheng, Y.C.2
  • 41
    • 0030665659 scopus 로고    scopus 로고
    • The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy
    • Strasser, A., D. C. Huan and, D. L. Vaux: The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy. Biochim Biophys Acta 1333, F151-F178 (1997)
    • (1997) Biochim Biophys Acta , vol.1333
    • Strasser, A.1    Huan, D.C.2    Vaux, D.L.3
  • 43
    • 0031657903 scopus 로고    scopus 로고
    • The transport of the anti-HIV drug, 2′,3′-didehydro-3′- deoxythymidine (D4T), across the blood-brain and blood-cerebrospinal fluid barriers
    • Thomas, S. A. and M. B. Segal: The transport of the anti-HIV drug, 2′,3′-didehydro-3′-deoxythymidine (D4T), across the blood-brain and blood-cerebrospinal fluid barriers. Br J Pharmacol 125, 49-54 (1998)
    • (1998) Br J Pharmacol , vol.125 , pp. 49-54
    • Thomas, S.A.1    Segal, M.B.2
  • 47
    • 0037096251 scopus 로고    scopus 로고
    • A novel function of monomeric amyloid beta-protein serving as an antioxidant molecule against metal-induced oxidative damage
    • Zou, K., J. S. Gong, K. Yanagisawa amd M. Michikawa: A novel function of monomeric amyloid beta-protein serving as an antioxidant molecule against metal-induced oxidative damage. J Neurosci 22, 4833-4841 (2002)
    • (2002) J Neurosci , vol.22 , pp. 4833-4841
    • Zou, K.1    Gong, J.S.2    Yanagisawa, K.3    Michikawa, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.