Human CD34+ hematopoietic progenitor cells are sensitive targets for toxicity induced by 1,4-benzoquinone

Toxicological Sciences

Volumn 79, Issue 1, 2004, Pages 82-89

  Abernethy, Diane J ^d   Kleymenova, Elena V ^d   Rose, Jason ^a,d   Recio, Leslie ^b,d   Faiola, Brenda ^c,d  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c GLAXOSMITHKLINE   (United States)

^d CIIT CENTERS FOR HEALTH RESEARCH   (United States)

Author keywords

Benzene; Benzoquinone; CD34; Cytotoxicity; DNA repair; Hematopoietic progenitor cells

Indexed keywords

1,4 BENZOQUINONE; CD34 ANTIGEN; MESSENGER RNA; PROTEIN P53; RAD51 PROTEIN;

ADULT; APOPTOSIS; ARTICLE; BLOOD DISEASE; BLOOD TOXICITY; CELL CULTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DNA REPAIR; FEMALE; GENOME; GENOTOXICITY; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA; LONG TERM EXPOSURE; MALE; MICRONUCLEUS; MUTAGENICITY; NUCLEOTIDE SEQUENCE; SEX DIFFERENCE; TOXICITY TESTING;

ADULT; ANTIGENS, CD34; APOPTOSIS; BENZOQUINONES; CELL CYCLE PROTEINS; CELL SURVIVAL; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENES, P53; HEMATOPOIETIC STEM CELLS; HUMANS; MALE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; RNA, MESSENGER; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 2442664068     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfh095     Document Type: Article

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