Male mice deficient in microsomal epoxide hydrolase are not susceptible to benzene-induced toxicity

Toxicological Sciences

Volumn 72, Issue 2, 2003, Pages 201-209

  Bauer, Alison K ^a   Faiola, Brenda ^a   Abernethy, Diane J ^a   Marchan, Rosemarie ^a   Pluta, Linda J ^a   Wong, Victoria A ^a   Gonzalez, Frank J ^b   Butterworth, Byron E ^a   Borghoff, Susan J ^a   Everitt, Jeffrey I ^a   Recio, Leslie ^a  

^a CIIT CENTERS FOR HEALTH RESEARCH   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Benzene; Bone marrow; Genotoxicity; Hematotoxicity; Leukemia; mEH; Micronuclei

Indexed keywords

BENZENE; DNA; EPOXIDE HYDROLASE; MESSENGER RNA; PROTEIN P21; PROTEIN P53;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD TOXICITY; BONE MARROW CELL; BONE MARROW TOXICITY; CANCER RISK; CONTROLLED STUDY; DNA DAMAGE; DOSE RESPONSE; FEMALE; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTOXICITY; LEUKEMIA; LEUKOCYTE COUNT; MALE; MICRONUCLEUS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SEX DIFFERENCE; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, INHALATION; ANIMALS; BENZENE; BONE MARROW CELLS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPOXIDE HYDROLASES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HEMATOLOGIC DISEASES; LEUKOCYTES; MALE; METABOLIC DETOXICATION, DRUG; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; MICRONUCLEUS TESTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEX FACTORS; SPECIFIC PATHOGEN-FREE ORGANISMS;

ANIMALIA;

EID: 0037389711     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfg024     Document Type: Article

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