Calpain inhibitors confer biochemical, but not electrophysiological, protection against anoxia in rat optic nerves

Journal of Neurochemistry

Volumn 74, Issue 5, 2000, Pages 2101-2107

  Jiang, Qiubo ^a   Stys, Peter K ^a,b  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Anoxia; Axon; Calcium; Sodium channel; Spectrin; White matter

Indexed keywords

[1 [(1 FORMYL 2 PHENYLETHYL)CARBAMOYL] 2 METHYLPROPYL]CARBAMIC ACID BENZYL ESTER; CALCIUM; CALPASTATIN; SODIUM CHANNEL; SPECTRIN; TETRODOTOXIN;

ADOLESCENT; ANIMAL MODEL; ANIMAL TISSUE; ANOXIA; ARTICLE; BRAIN PROTECTION; ELECTROPHYSIOLOGY; MALE; NERVE FIBER; NEUROCHEMISTRY; NONHUMAN; OPTIC NERVE LESION; PRIORITY JOURNAL; RAT; REOXYGENATION; WHITE MATTER;

ANIMALS; ANOXIA; CALCIUM; CALPAIN; CYSTEINE PROTEINASE INHIBITORS; DIPEPTIDES; ELECTROPHYSIOLOGY; GLYCOPROTEINS; ION CHANNEL GATING; MALE; OPTIC NERVE; OXYGEN; RATS; RATS, LONG-EVANS; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; SPECTRIN; TETRODOTOXIN; TIME FACTORS;

ANIMALIA;

EID: 0034090253     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0742101.x     Document Type: Article

References (45)

1. Arai A., Kessler M., Lee K., and Lynch G. (1990) Calpain inhibitors improve the recovery of synaptic transmission from hypoxia in hippocampal slices. Brain Res. 532, 63-68.
2. Brorson J. R., Marcuccilli C. J., and Miller R. J. (1995) Delayed antagonism of calpain reduces excitotoxicity in cultured neurons. Stroke 26, 1259-1266.
3. Buki A., Siman R., Trojanowski J. Q., and Povlishock J. T. (1999) The role of calpain-mediated spectrin proteolysis in traumatically induced axonal injury. J. Neuropathol. Exp. Neurol. 58, 365-375.
4. Caner H., Collins J. L., Harris S. M., Kassell N. F., and Lee K. S. (1993) Attenuation of AMPA-induced neurotoxicity by a calpain inhibitor. Brain Res. 607, 354-356.
5. Chen Z. F., Schottler F., and Lee K. S. (1997) Neuronal recovery after moderate hypoxia is improved by the calpain inhibitor MDL28170. Brain Res. 769, 188-192.
6. Croall D. E. and DeMartino G. N. (1991) Calcium-activated neutral protease (calpain) system: structure, function, and regulation. Physiol. Rev. 71, 813-847.
7. del Cerro S., Larson J., Oliver M. W., and Lynch G. (1990) Development of hippocampal long-term potentiation is reduced by recently introduced calpain inhibitors. Brain Res. 530, 91-95.
8. Deshpande R. V., Goust J. M., Hogan E. L., and Banik N. L. (1995) Calpain secreted by activated human lymphoid cells degrades myelin. J. Neurosci. Res. 42, 259-265.
9. Faddis B. T., Hasbani M. J., and Goldberg M. P. (1997) Calpain activation contributes to dendritic remodeling after brief excitotoxic injury in vitro. J. Neurosci. 17, 951-959.
10. Fern R., Ransom B., Stys P. K., and Waxman S. G. (1993) Pharmacological protection of CNS white matter during anoxia: actions of phenytoin, carbamazepine and diazepam. J. Pharmacol. Exp. Ther. 266, 1549-1555.
11. Giancotti F. G., Stepp M. A., Suzuki S., Engvall E., and Ruoslahti E. (1992) Proteolytic processing of endogenous and recombinant beta 4 integrin subunit. J. Cell Biol. 118, 951-959.
12. Hamakubo T., Kannagi R., Murachi T., and Matus A. (1986) Distribution of calpains I and II in rat brain. J. Neurosci. 6, 3103-3111.
13. Hewitt K. E., Lesiuk H. J., Tauskela J. S., Morley P., and Durkin J. P. (1998) Selective coupling of μ-calpain activation with the NMDA receptor is independent of translocation and autolysis in primary cortical neurons. J. Neurosci. Res. 54, 223-232.
14. Hirai S., Kawasaki H., Yaniv M., and Suzuki K. (1991) Degradation of transcription factors, c-Jun and c-Fos, by calpain. FEBS Lett. 287, 57-61.
15. James T., Matzelle D., Bartus R., Hogan E. L., and Banik N. L. (1998) New inhibitors of calpain prevent degradation of cytoskeletal and myelin proteins in spinal cord in vitro. J. Neurosci. Res. 51, 218-222.
16. Kampfl A., Posmantur R. M., Zhao X., Schmutzhard E., Clifton G. L., and Hayes R. L. (1997) Mechanisms of calpain proteolysis following traumatic brain injury: implications for pathology and therapy: a review and update. J. Neurotrauma 14, 121-134.
17. Lee K. S., Frank S., Vanderklish P., Arai A., and Lynch G. (1991) Inhibition of proteolysis protects hippocampal neurons from ischemia. Proc. Natl. Acad. Sci. USA 88, 7233-7237.
18. Li Z. and Banik N. L. (1995) The localization of m-calpain in myelin: immunocytochemical evidence in different areas of rat brain and nerves. Brain Res. 697, 112-121.
19. LoPachin R. M. and Stys P. K. (1995) Elemental composition and water content of rat optic nerve myelinated axons and glial cells: effects of in vitro anoxia and reoxygenation. J. Neurosci. 15, 6735-6746.
20. LoPachin R. M., Gaughan C. L., Lehning E. J., Kaneko Y., Kelly T. M., and Blight A. (1999) Experimental spinal cord injury: spatiotemporal characterization of elemental concentrations and water contents in axons and neuroglia. J. Neurophysiol. 82, 2143-2153.
21. Manev H., Favaron M., Siman R., Guidotti A., and Costa E. (1991) Glutamate neurotoxicity is independent of calpain I inhibition in primary cultures of cerebellar granule cells. J. Neurochem. 57, 1288-1295.
22. McIntosh T. K., Saatman K. E., and Raghupathi R. (1997) Calcium and the pathogenesis of traumatic CNS injury: cellular and molecular mechanisms. Neuroscientist 3, 169-175.
23. Melloni E. and Pontremoli S. (1989) The calpains. Trends Neurosci. 12, 438-444.
24. Mouatt-Prigent A., Karlsson J. O., Agid Y., and Hirsch E. C. (1996) Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death? Neuroscience 73, 979-987.
25. Neumar R. W., Hagle S. M., DeGracia D. J., Krause G. S., and White B. C. (1996) Brain μ-calpain autolysis during global cerebral ischemia. J. Neurochem. 66, 421-424.
26. Nixon R. A., Quackenbush R., and Vitto A. (1986) Multiple calcium-activated neutral proteinases (CANP) in mouse retinal ganglion cell neurons: specificities for endogenous neuronal substrates and comparison to purified brain CANP. J. Neurosci. 6, 1252-1263.
27. Orrenius S. and Nicotera P. (1996) Mechanisms of calcium-related cell death, in Cellular and Molecular Mechanisms of Ischemic Brain Damage (Siesjö B. K. and Wieloch T., eds), pp. 137-152. Raven Press, New York.
28. Perlmutter L. S., Gall C., Baudry M., and Lynch G. (1990) Distribution of calcium-activated protease calpain in the rat brain. J. Comp. Neurol. 296, 269-276.
29. Posmantur R., Kampfl A., Siman R., Liu J., Zhao X., Clifton G. L., and Hayes R. L. (1997) A calpain inhibitor attenuates cortical cytoskeletal protein loss after experimental traumatic brain injury in the rat. Neuroscience 77, 875-888.
30. Rami A. and Krieglstein J. (1993) Protective effects of calpain inhibitors against neuronal damage caused by cytotoxic hypoxia in vitro and ischemia in vivo. Brain Res. 609, 67-70.
31. Rami A., Ferger D., and Krieglstein J. (1997) Blockade of calpain proteolytic activity rescues neurons from glutamate excitotoxicity. Neurosci. Res. 27, 93-97.
32. Roberts-Lewis J. M., Savage M. J., Marcy V. R., Pinsker L. R., and Siman R. (1994) Immunolocalization of calpain I-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain. J. Neurosci. 14, 3934-3944.
33. Saito K., Elce J. S., Hamos J. E., and Nixon R. A. (1993) Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration. Proc. Natl. Acad. Sci. USA 90, 2628-2632.
34. Salamino F., Sparatore B., Melloni E., Michetti M., Viotti P. L., Pontremoli S., and Carafoli E. (1994) The plasma membrane calcium pump is the preferred calpain substrate within the erythrocyte. Cell Calcium 15, 28-35.
35. Schumacher P. A., Eubanks J. H., and Fehlings M. G. (1999) Increased calpain I-mediated proteolysis, and preferential loss of dephosphorylated NF200, following traumatic spinal cord injury. Neuroscience 91, 733-744.
36. Shields D. C., Schaecher K. E., Saido T. C., and Banik N. L. (1999) A putative mechanism of demyelination in multiple sclerosis by a proteolytic enzyme, calpain. Proc. Natl. Acad. Sci. USA 96, 11486-11491.
37. Siman R., Baudry M., and Lynch G. (1984) Brain fodrin: substrate for calpain I, an endogenous calcium-activated protease. Proc. Natl. Acad. Sci. USA 81, 3572-3576.
38. Siman R., Noszek J. C., and Kegerise C. (1989) Calpain I activation is specifically related to excitatory amino acid induction of hippocampal damage. J. Neurosci. 9, 1579-1590.
39. Stys P. K. and LoPachin R. M. (1996) Elemental composition and water content of rat optic nerve myelinated axons during in vitro post-anoxia reoxygenation. Neuroscience 73, 1081-1090.
40. Stys P. K. and LoPachin R. M. (1998) Mechanisms of ion flux in anoxic myelinated CNS axons. Neuroscience 82, 21-32.
41. Stys P. K., Ransom B. R., Waxman S. G., and Davis P. K. (1990) Role of extracellular calcium in anoxic injury of mammalian central white matter. Proc. Natl. Acad. Sci. USA 87, 4212-4216.
42. Stys P. K., Ransom B. R., and Waxman S. G. (1991) Compound action potential of nerve recorded by suction electrode: a theoretical and experimental analysis. Brain Res. 546, 18-32.
43. 2+ exchanger. J. Neurosci. 12, 430-439.
44. Wang K. K. (1990) Developing selective inhibitors of calpain. Trends Pharmacol. Sci. 11, 139-142.
45. Wang K. K. W. and Yuen P.-W. (1994) Calpain inhibition: an overview of its therapeutic potential. Trends Pharmacol. Sci. 15, 412-419.