3′-methylphosphonate-modified oligo-2′-O-methylribonucleotides and their Tat peptide conjugates: Uptake and stability in mouse fibroblasts in culture

Bioconjugate Chemistry

Volumn 15, Issue 3, 2004, Pages 498-507

  Prater, Chrissy E ^a   Miller, Paul S ^a  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CELL CULTURE; COVALENT BONDS; ELECTROPHORESIS; FIBROBLASTS; FLUORESCENCE MICROSCOPY; MAMMALS; MASS SPECTROMETRY; PEPTIDES; SULFUR COMPOUNDS;

ANTISENSE; BINDING AFFINITIES; CATIONIC LIPIDS; EXONUCLEASE ACTIVITY; LYSATES; METHYLPHOSPHONATES; MOUSE-FIBROBLASTS; PHYSIOLOGICAL CONDITION; POLYACRYLAMIDE GEL ELECTROPHORESIS; TAT PEPTIDE;

OLIGONUCLEOTIDES;

3' METHYLPHOSPHONATE; 4 [2 AMINOOXYETHOXY 2 (ETHYLUREIDO)]QUINOLINE; CATION; DISULFIDE; EXONUCLEASE; FLUORESCEIN; GLASS; LIPID; METHYLPHOSPHONIC ACID; OLIGO 2' O METHYLRIBONUCLEOTIDE; OLIGOFECTAMINE; OLIGOMER; PEPTIDE; PHOSPHONIC ACID DERIVATIVE; PHOSPHORUS 32; PLASTIC; QUINOLINE DERIVATIVE; SPLEEN EXONUCLEASE; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG; ANTISENSE OLIGONUCLEOTIDE; ORGANOPHOSPHORUS COMPOUND;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL CULTURE; CELL LYSATE; CELL NUCLEUS; CELL PERMEABILIZATION; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CONJUGATION; CULTURE MEDIUM; DISULFIDE BOND; ENZYME ACTIVITY; FIBROBLAST; FLUORESCENCE MICROSCOPY; MASS SPECTROMETRY; MOUSE; NONHUMAN; NUCLEOTIDE METABOLISM; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; SEQUENCE ANALYSIS; ANIMAL; CHEMISTRY; DRUG STABILITY; METABOLISM; PHYSIOLOGY; PROTEIN BINDING; SERUM; SYNTHESIS;

ANIMALIA; MAMMALIA;

ANIMALS; CELLS, CULTURED; DRUG STABILITY; EXONUCLEASES; FIBROBLASTS; GENE PRODUCTS, TAT; MICE; OLIGONUCLEOTIDES, ANTISENSE; ORGANOPHOSPHORUS COMPOUNDS; PEPTIDES; PROTEIN BINDING; SERUM;

EID: 2442658178     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc049977+     Document Type: Article

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