A novel class of orally active non-peptide bradykinin B2 receptor antagonists. 4. Discovery of novel frameworks mimicking the active conformation

Journal of Medicinal Chemistry

Volumn 41, Issue 23, 1998, Pages 4587-4598

  Abe, Yoshito ^a   Kayakiri, Hiroshi ^a   Satoh, Shigeki ^a   Inoue, Takayuki ^a   Sawada, Yuki ^a   Inamura, Noriaki ^a   Asano, Masayuki ^a   Aramori, Ichiro ^a   Hatori, Chie ^a   Sawai, Hiroe ^a   Oku, Teruo ^a   Tanaka, Hirokazu ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 (6 ACETAMIDO 3 PYRIDYL) N [N [2,4 DICHLORO 3 [(2 METHYL 8 QUINOLINYL)OXYMETHYL]PHENYL] N METHYLAMINOCARBONYLMETHYL]ACRYLAMIDE; BRADYKININ B2 RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRONCHODILATATION; DRUG CONFORMATION; DRUG POTENCY; DRUG RECEPTOR BINDING; GUINEA PIG; ILEUM; MALE; NONHUMAN; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; AMINOPYRIDINES; ANIMALS; BRADYKININ; BRONCHOCONSTRICTION; CHO CELLS; CRICETINAE; GUINEA PIGS; HUMANS; ILEUM; MALE; MOLECULAR CONFORMATION; MOLECULAR MIMICRY; QUINOLINES; RECEPTOR, BRADYKININ B2; RECEPTORS, BRADYKININ; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 14444267777     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980330i     Document Type: Article

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